Q9H6V9: Lipid droplet-associated hydrolase {ECO:0000312|HGNC:HGNC:26145}

General Information

Protein names	- Lipid droplet-associated hydrolase {ECO:0000312\|HGNC:HGNC:26145} - 3.1.1.- {ECO:0000250\|UniProtKB:Q8BVA5} - Lipid droplet-associated serine hydrolase {ECO:0000303\|PubMed:24357060} - hLDAH {ECO:0000303\|PubMed:24357060}
Gene names	C2orf43
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9H6V9

2 N-termini

4 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of UPF0554 protein C2orf43 - Isoform 3 of UPF0554 protein C2orf43 - Isoform 2 of Lipid droplet-associated hydrolase - Isoform 3 of Lipid droplet-associated hydrolase - Isoform 4 of Lipid droplet-associated hydrolase

Sequence View

        10         20         30         40         50         60
MDSELKEEIP VHEEFILCGG AETQVLKCGP WTDLFHDQSV KRPKLLIFII PGNPGFSAFY
        70         80         90        100        110        120
VPFAKALYSL TNRRFPVWTI SHAGHALAPK DKKILTTSED SNAQEIKDIY GLNGQIEHKL
       130        140        150        160        170        180
AFLRTHVPKD MKLVLIGHSI GSYFTLQMLK RVPELPVIRA FLLFPTIERM SESPNGRIAT
       190        200        210        220        230        240
PLLCWFRYVL YVTGYLLLKP CPETIKSLLI RRGLQVMNLE NEFSPLNILE PFCLANAAYL
       250        260        270        280        290        300
GGQEMMEVVK RDDETIKEHL CKLTFYYGTI DPWCPKEYYE DIKKDFPEGD IRLCEKNIPH
       310        320
AFITHFNQEM ADMIADSLKD DLSKM         10         20         30         40         50         60
MDSELKEEIP VHEEFILCGG AETQVLKCGP WTDLFHDQSV KRPKLLIFII PGNPGFSAFY
        70         80         90        100        110        120
VPFAKALYSL TNRRFPVWTI SHAGHALAPK DKKILTTSED SNAQEIKDIY GLNGQIEHKL
       130        140        150        160        170        180
AFLRTHVPKD MKLVLIGHSI GSYFTLQMLK RVPELPVIRA FLLFPTIERM SESPNGRIAT
       190        200        210        220        230        240
PLLCWFRYVL YVTGYLLLKP CPETIKSLLI RRGLQVMNLE NEFSPLNILE PFCLANAAYL
       250        260        270        280        290        300
GGQEMMEVVK RDDETIKEHL CKLTFYYGTI DPWCPKEYYE DIKKDFPEGD IRLCEKNIPH
       310        320
AFITHFNQEM ADMIADSLKD DLSKM         10         20         30         40         50         60
MDSELKEEIP VHEEFILCGG AETQVLKCGP WTDLFHDQSV KRPKLLIFII PGNPGFSAFY
        70         80         90        100        110        120
VPFAKALYSL TNRRFPVWTI SHAGHALAPK DKKILTTSED SNAQEIKDIY GLNGQIEHKL
       130        140        150        160        170        180
AFLRTHVPKD MKLVLIGHSI GSYFTLQMLK RVPELPVIRA FLLFPTIERM SESPNGRIAT
       190        200        210        220        230        240
PLLCWFRYVL YVTGYLLLKP CPETIKSLLI RRGLQVMNLE NEFSPLNILE PFCLANAAYL
       250        260        270        280        290        300
GGQEMMEVVK RDDETIKEHL CKLTFYYGTI DPWCPKEYYE DIKKDFPEGD IRLCEKNIPH
       310        320
AFITHFNQEM ADMIADSLKD DLSKM         10         20         30         40         50         60
MDSELKEEIP VHEEFILCGG AETQVLKCGP WTDLFHDQSV KRPKLLIFII PGNPGFSAFY
        70         80         90        100        110        120
VPFAKALYSL TNRRFPVWTI SHAGHALAPK DKKILTTSED SNAQEIKDIY GLNGQIEHKL
       130        140        150        160        170        180
AFLRTHVPKD MKLVLIGHSI GSYFTLQMLK RVPELPVIRA FLLFPTIERM SESPNGRIAT
       190        200        210        220        230        240
PLLCWFRYVL YVTGYLLLKP CPETIKSLLI RRGLQVMNLE NEFSPLNILE PFCLANAAYL
       250        260        270        280        290        300
GGQEMMEVVK RDDETIKEHL CKLTFYYGTI DPWCPKEYYE DIKKDFPEGD IRLCEKNIPH
       310        320
AFITHFNQEM ADMIADSLKD DLSKM         10         20         30         40         50         60
MDSELKEEIP VHEEFILCGG AETQVLKCGP WTDLFHDQSV KRPKLLIFII PGNPGFSAFY
        70         80         90        100        110        120
VPFAKALYSL TNRRFPVWTI SHAGHALAPK DKKILTTSED SNAQEIKDIY GLNGQIEHKL
       130        140        150        160        170        180
AFLRTHVPKD MKLVLIGHSI GSYFTLQMLK RVPELPVIRA FLLFPTIERM SESPNGRIAT
       190        200        210        220        230        240
PLLCWFRYVL YVTGYLLLKP CPETIKSLLI RRGLQVMNLE NEFSPLNILE PFCLANAAYL
       250        260        270        280        290        300
GGQEMMEVVK RDDETIKEHL CKLTFYYGTI DPWCPKEYYE DIKKDFPEGD IRLCEKNIPH
       310        320
AFITHFNQEM ADMIADSLKD DLSKM

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 4 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9H6V9-1-unknown	MDSELK...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9H6V9-1-unknown	MDSELK...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt69397
Q9H6V9-1-unknown	MDSELK...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt69398
Q9H6V9-131-unknown	MKLVLI...	131	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000384267
Q9H6V9-131-unknown	MKLVLI...	131	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000396911
Q9H6V9-131-unknown	MKLVLI...	131	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000440570
Q9H6V9-131-unknown	MKLVLI...	131	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt197418
Q9H6V9-131-unknown	MKLVLI...	131	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt197419

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...IGHSIG	140	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000385951
...IGHSIG	140	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154863
...IGHSIG	140	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154864
...ETIKSL	207	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000400910
...ETIKSL	207	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155707
...ETIKSL	207	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155708
...IKEHLC	260	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000396911
...DLSKM	325	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...DLSKM	325	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt65016
...DLSKM	325	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt65015

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)