TopFIND 4.0

Q9H7B4: Histone-lysine N-methyltransferase SMYD3

General Information

Protein names
- Histone-lysine N-methyltransferase SMYD3
- 2.1.1.43
- SET and MYND domain-containing protein 3
- Zinc finger MYND domain-containing protein 1
Gene names SMYD3
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q9H7B4

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MEPLKVEKFA TAKRGNGLRA VTPLRPGELL FRSDPLAYTV CKGSRGVVCD RCLLGKEKLM 
        70         80         90        100        110        120 
RCSQCRVAKY CSAKCQKKAW PDHKRECKCL KSCKPRYPPD SVRLLGRVVF KLMDGAPSES 
       130        140        150        160        170        180 
EKLYSFYDLE SNINKLTEDK KEGLRQLVMT FQHFMREEIQ DASQLPPAFD LFEAFAKVIC 
       190        200        210        220        230        240 
NSFTICNAEM QEVGVGLYPS ISLLNHSCDP NCSIVFNGPH LLLRAVRDIE VGEELTICYL 
       250        260        270        280        290        300 
DMLMTSEERR KQLRDQYCFE CDCFRCQTQD KDADMLTGDE QVWKEVQESL KKIEELKAHW 
       310        320        330        340        350        360 
KWEQVLAMCQ AIISSNSERL PDINIYQLKV LDCAMDACIN LGLLEEALFY GTRTMEPYRI 
       370        380        390        400        410        420 
FFPGSHPVRG VQVMKVGKLQ LHQGMFPQAM KNLRLAFDIM RVTHGREHSL IEDLILLLEE 
   
CDANIRAS

Isoforms

- Isoform 2 of Histone-lysine N-methyltransferase SMYD3 - Isoform 3 of Histone-lysine N-methyltransferase SMYD3

Sequence View

        10         20         30         40         50         60 
MEPLKVEKFA TAKRGNGLRA VTPLRPGELL FRSDPLAYTV CKGSRGVVCD RCLLGKEKLM 
        70         80         90        100        110        120 
RCSQCRVAKY CSAKCQKKAW PDHKRECKCL KSCKPRYPPD SVRLLGRVVF KLMDGAPSES 
       130        140        150        160        170        180 
EKLYSFYDLE SNINKLTEDK KEGLRQLVMT FQHFMREEIQ DASQLPPAFD LFEAFAKVIC 
       190        200        210        220        230        240 
NSFTICNAEM QEVGVGLYPS ISLLNHSCDP NCSIVFNGPH LLLRAVRDIE VGEELTICYL 
       250        260        270        280        290        300 
DMLMTSEERR KQLRDQYCFE CDCFRCQTQD KDADMLTGDE QVWKEVQESL KKIEELKAHW 
       310        320        330        340        350        360 
KWEQVLAMCQ AIISSNSERL PDINIYQLKV LDCAMDACIN LGLLEEALFY GTRTMEPYRI 
       370        380        390        400        410        420 
FFPGSHPVRG VQVMKVGKLQ LHQGMFPQAM KNLRLAFDIM RVTHGREHSL IEDLILLLEE 
   
CDANIRAS         10         20         30         40         50         60 
MEPLKVEKFA TAKRGNGLRA VTPLRPGELL FRSDPLAYTV CKGSRGVVCD RCLLGKEKLM 
        70         80         90        100        110        120 
RCSQCRVAKY CSAKCQKKAW PDHKRECKCL KSCKPRYPPD SVRLLGRVVF KLMDGAPSES 
       130        140        150        160        170        180 
EKLYSFYDLE SNINKLTEDK KEGLRQLVMT FQHFMREEIQ DASQLPPAFD LFEAFAKVIC 
       190        200        210        220        230        240 
NSFTICNAEM QEVGVGLYPS ISLLNHSCDP NCSIVFNGPH LLLRAVRDIE VGEELTICYL 
       250        260        270        280        290        300 
DMLMTSEERR KQLRDQYCFE CDCFRCQTQD KDADMLTGDE QVWKEVQESL KKIEELKAHW 
       310        320        330        340        350        360 
KWEQVLAMCQ AIISSNSERL PDINIYQLKV LDCAMDACIN LGLLEEALFY GTRTMEPYRI 
       370        380        390        400        410        420 
FFPGSHPVRG VQVMKVGKLQ LHQGMFPQAM KNLRLAFDIM RVTHGREHSL IEDLILLLEE 
   
CDANIRAS



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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q9H7B4-1-Acetylation MEPLKV... 1 acetylation- inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q9H7B4-60-unknown MRCSQC... 60 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt90115

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)