Q9H7D0: Dedicator of cytokinesis protein 5
| Protein names | - Dedicator of cytokinesis protein 5 |
|---|---|
| Gene names | DOCK5 |
| Organism | Homo sapiens |
| Protease Family | |
| Protease ID | |
| Chromosome location | |
| UniProt ID | Q9H7D0 |
2
N-termini
4
C-termini
1
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MARWIPTKRQ KYGVAIYNYN ASQDVELSLQ IGDTVHILEM YEGWYRGYTL QNKSKKGIFP
70 80 90 100 110 120
ETYIHLKEAT VEDLGQHETV IPGELPLVQE LTSTLREWAV IWRKLYVNNK LTLFRQLQQM
130 140 150 160 170 180
TYSLIEWRSQ ILSGTLPKDE LAELKKKVTA KIDHGNRMLG LDLVVRDDNG NILDPDETST
190 200 210 220 230 240
IALFKAHEVA SKRIEEKIQE EKSILQNLDL RGQSIFSTIH TYGLYVNFKN FVCNIGEDAE
250 260 270 280 290 300
LFMALYDPDQ STFISENYLI RWGSNGMPKE IEKLNNLQAV FTDLSSMDLI RPRVSLVCQI
310 320 330 340 350 360
VRVGHMELKE GKKHTCGLRR PFGVAVMDIT DIIHGKVDDE EKQHFIPFQQ IAMETYIRQR
370 380 390 400 410 420
QLIMSPLITS HVIGENEPLT SVLNKVIAAK EVNHKGQGLW VSLKLLPGDL TQVQKNFSHL
430 440 450 460 470 480
VDRSTAIARK MGFPEIILPG DVRNDIYVTL IHGEFDKGKK KTPKNVEVTM SVHDEEGKLL
490 500 510 520 530 540
EKAIHPGAGY EGISEYKSVV YYQVKQPCWY ETVKVSIAIE EVTRCHIRFT FRHRSSQETR
550 560 570 580 590 600
DKSERAFGVA FVKLMNPDGT TLQDGRHDLV VYKGDNKKME DAKFYLTLPG TKMEMEEKEL
610 620 630 640 650 660
QASKNLVTFT PSKDSTKDSF QIATLICSTK LTQNVDLLGL LNWRSNSQNI KHNLKKLMEV
670 680 690 700 710 720
DGGEIVKFLQ DTLDALFNIM MEMSDSETYD FLVFDALVFI ISLIGDIKFQ HFNPVLETYI
730 740 750 760 770 780
YKHFSATLAY VKLSKVLNFY VANADDSSKT ELLFAALKAL KYLFRFIIQS RVLYLRFYGQ
790 800 810 820 830 840
SKDGDEFNNS IRQLFLAFNM LMDRPLEEAV KIKGAALKYL PSIINDVKLV FDPVELSVLF
850 860 870 880 890 900
CKFIQSIPDN QLVRQKLNCM TKIVESTLFR QSECREVLLP LLTDQLSGQL DDNSNKPDHE
910 920 930 940 950 960
ASSQLLSNIL EVLDRKDVGA TAVHIQLIME RLLRRINRTV IGMNRQSPHI GSFVACMIAL
970 980 990 1000 1010 1020
LQQMDDSHYS HYISTFKTRQ DIIDFLMETF IMFKDLIGKN VYAKDWMVMN MTQNRVFLRA
1030 1040 1050 1060 1070 1080
INQFAEVLTR FFMDQASFEL QLWNNYFHLA VAFLTHESLQ LETFSQAKRN KIVKKYGDMR
1090 1100 1110 1120 1130 1140
KEIGFRIRDM WYNLGPHKIK FIPSMVGPIL EVTLTPEVEL RKATIPIFFD MMQCEFNFSG
1150 1160 1170 1180 1190 1200
NGNFHMFENE LITKLDQEVE GGRGDEQYKV LLEKLLLEHC RKHKYLSSSG EVFALLVSSL
1210 1220 1230 1240 1250 1260
LENLLDYRTI IMQDESKENR MSCTVNVLNF YKEKKREDIY IRYLYKLRDL HRDCENYTEA
1270 1280 1290 1300 1310 1320
AYTLLLHAEL LQWSDKPCVP HLLQKDSYYV YTQQELKEKL YQEIISYFDK GKMWEKAIKL
1330 1340 1350 1360 1370 1380
SKELAETYES KVFDYEGLGN LLKKRASFYE NIIKAMRPQP EYFAVGYYGQ GFPSFLRNKI
1390 1400 1410 1420 1430 1440
FIYRGKEYER REDFSLRLLT QFPNAEKMTS TTPPGEDIKS SPKQYMQCFT VKPVMSLPPS
1450 1460 1470 1480 1490 1500
YKDKPVPEQI LNYYRANEVQ QFRYSRPFRK GEKDPDNEFA TMWIERTTYT TAYTFPGILK
1510 1520 1530 1540 1550 1560
WFEVKQISTE EISPLENAIE TMELTNERIS NCVQQHAWDR SLSVHPLSML LSGIVDPAVM
1570 1580 1590 1600 1610 1620
GGFSNYEKAF FTEKYLQEHP EDQEKVELLK RLIALQMPLL TEGIRIHGEK LTEQLKPLHE
1630 1640 1650 1660 1670 1680
RLSSCFRELK EKVEKHYGVI TLPPNLTERK QSRTGSIVLP YIMSSTLRRL SITSVTSSVV
1690 1700 1710 1720 1730 1740
STSSNSSDNA PSRPGSDGSI LEPLLERRAS SGARVEDLSL REENSENRIS KFKRKDWSLS
1750 1760 1770 1780 1790 1800
KSQVIAEKAP EPDLMSPTRK AQRPKSLQLM DNRLSPFHGS SPPQSTPLSP PPLTPKATRT
1810 1820 1830 1840 1850 1860
LSSPSLQTDG IAATPVPPPP PPKSKPYEGS QRNSTELAPP LPVRREAKAP PPPPPKARKS
1870
GIPTSEPGSQ
Isoforms
- Isoform 2 of Dedicator of cytokinesis protein 5Sequence View
10 20 30 40 50 60
MARWIPTKRQ KYGVAIYNYN ASQDVELSLQ IGDTVHILEM YEGWYRGYTL QNKSKKGIFP
70 80 90 100 110 120
ETYIHLKEAT VEDLGQHETV IPGELPLVQE LTSTLREWAV IWRKLYVNNK LTLFRQLQQM
130 140 150 160 170 180
TYSLIEWRSQ ILSGTLPKDE LAELKKKVTA KIDHGNRMLG LDLVVRDDNG NILDPDETST
190 200 210 220 230 240
IALFKAHEVA SKRIEEKIQE EKSILQNLDL RGQSIFSTIH TYGLYVNFKN FVCNIGEDAE
250 260 270 280 290 300
LFMALYDPDQ STFISENYLI RWGSNGMPKE IEKLNNLQAV FTDLSSMDLI RPRVSLVCQI
310 320 330 340 350 360
VRVGHMELKE GKKHTCGLRR PFGVAVMDIT DIIHGKVDDE EKQHFIPFQQ IAMETYIRQR
370 380 390 400 410 420
QLIMSPLITS HVIGENEPLT SVLNKVIAAK EVNHKGQGLW VSLKLLPGDL TQVQKNFSHL
430 440 450 460 470 480
VDRSTAIARK MGFPEIILPG DVRNDIYVTL IHGEFDKGKK KTPKNVEVTM SVHDEEGKLL
490 500 510 520 530 540
EKAIHPGAGY EGISEYKSVV YYQVKQPCWY ETVKVSIAIE EVTRCHIRFT FRHRSSQETR
550 560 570 580 590 600
DKSERAFGVA FVKLMNPDGT TLQDGRHDLV VYKGDNKKME DAKFYLTLPG TKMEMEEKEL
610 620 630 640 650 660
QASKNLVTFT PSKDSTKDSF QIATLICSTK LTQNVDLLGL LNWRSNSQNI KHNLKKLMEV
670 680 690 700 710 720
DGGEIVKFLQ DTLDALFNIM MEMSDSETYD FLVFDALVFI ISLIGDIKFQ HFNPVLETYI
730 740 750 760 770 780
YKHFSATLAY VKLSKVLNFY VANADDSSKT ELLFAALKAL KYLFRFIIQS RVLYLRFYGQ
790 800 810 820 830 840
SKDGDEFNNS IRQLFLAFNM LMDRPLEEAV KIKGAALKYL PSIINDVKLV FDPVELSVLF
850 860 870 880 890 900
CKFIQSIPDN QLVRQKLNCM TKIVESTLFR QSECREVLLP LLTDQLSGQL DDNSNKPDHE
910 920 930 940 950 960
ASSQLLSNIL EVLDRKDVGA TAVHIQLIME RLLRRINRTV IGMNRQSPHI GSFVACMIAL
970 980 990 1000 1010 1020
LQQMDDSHYS HYISTFKTRQ DIIDFLMETF IMFKDLIGKN VYAKDWMVMN MTQNRVFLRA
1030 1040 1050 1060 1070 1080
INQFAEVLTR FFMDQASFEL QLWNNYFHLA VAFLTHESLQ LETFSQAKRN KIVKKYGDMR
1090 1100 1110 1120 1130 1140
KEIGFRIRDM WYNLGPHKIK FIPSMVGPIL EVTLTPEVEL RKATIPIFFD MMQCEFNFSG
1150 1160 1170 1180 1190 1200
NGNFHMFENE LITKLDQEVE GGRGDEQYKV LLEKLLLEHC RKHKYLSSSG EVFALLVSSL
1210 1220 1230 1240 1250 1260
LENLLDYRTI IMQDESKENR MSCTVNVLNF YKEKKREDIY IRYLYKLRDL HRDCENYTEA
1270 1280 1290 1300 1310 1320
AYTLLLHAEL LQWSDKPCVP HLLQKDSYYV YTQQELKEKL YQEIISYFDK GKMWEKAIKL
1330 1340 1350 1360 1370 1380
SKELAETYES KVFDYEGLGN LLKKRASFYE NIIKAMRPQP EYFAVGYYGQ GFPSFLRNKI
1390 1400 1410 1420 1430 1440
FIYRGKEYER REDFSLRLLT QFPNAEKMTS TTPPGEDIKS SPKQYMQCFT VKPVMSLPPS
1450 1460 1470 1480 1490 1500
YKDKPVPEQI LNYYRANEVQ QFRYSRPFRK GEKDPDNEFA TMWIERTTYT TAYTFPGILK
1510 1520 1530 1540 1550 1560
WFEVKQISTE EISPLENAIE TMELTNERIS NCVQQHAWDR SLSVHPLSML LSGIVDPAVM
1570 1580 1590 1600 1610 1620
GGFSNYEKAF FTEKYLQEHP EDQEKVELLK RLIALQMPLL TEGIRIHGEK LTEQLKPLHE
1630 1640 1650 1660 1670 1680
RLSSCFRELK EKVEKHYGVI TLPPNLTERK QSRTGSIVLP YIMSSTLRRL SITSVTSSVV
1690 1700 1710 1720 1730 1740
STSSNSSDNA PSRPGSDGSI LEPLLERRAS SGARVEDLSL REENSENRIS KFKRKDWSLS
1750 1760 1770 1780 1790 1800
KSQVIAEKAP EPDLMSPTRK AQRPKSLQLM DNRLSPFHGS SPPQSTPLSP PPLTPKATRT
1810 1820 1830 1840 1850 1860
LSSPSLQTDG IAATPVPPPP PPKSKPYEGS QRNSTELAPP LPVRREAKAP PPPPPKARKS
1870
GIPTSEPGSQ
Protein Neighborhood
Domains & Features
2 N-termini - 4 C-termini - 1 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| Q9H7D0-1-unknown | MARWIP... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| Q9H7D0-1-unknown | MARWIP... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt73106 | |||
| Q9H7D0-1810-unknown | GIAATP... | 1810 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC1350 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...IPFQQI | 350 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt68724 | |||
| ...SLQTDG | 1809 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC1350 | |||
| ...EPGSQ | 1870 | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345, | |||
| ...EPGSQ | 1870 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| ...EPGSQ | 1870 | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345, |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| CASP1_HUMAN | 1809 | QTDG.|.GIAA | inferred from experiment | unknown | MEROPS | Wells JA | Agard NJ et al.:Inflammatory stimuli regulate c... (C14.001) | 20173201, |
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|