TopFIND 4.0

Q9HAT2: Sialate O-acetylesterase

General Information

Protein names
- Sialate O-acetylesterase
- 3.1.1.53
- H-Lse
- Sialic acid-specific 9-O-acetylesterase
Gene names SIAE
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q9HAT2

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MVAPGLVLGL VLPLILWADR SAGIGFRFAS YINNDMVLQK EPAGAVIWGF GTPGATVTVT 
        70         80         90        100        110        120 
LRQGQETIMK KVTSVKAHSD TWMVVLDPMK PGGPFEVMAQ QTLEKINFTL RVHDVLFGDV 
       130        140        150        160        170        180 
WLCSGQSNMQ MTVLQIFNAT RELSNTAAYQ SVRILSVSPI QAEQELEDLV AVDLQWSKPT 
       190        200        210        220        230        240 
SENLGHGYFK YMSAVCWLFG RHLYDTLQYP IGLIASSWGG TPIEAWSSGR SLKACGVPKQ 
       250        260        270        280        290        300 
GSIPYDSVTG PSKHSVLWNA MIHPLCNMTL KGVVWYQGES NINYNTDLYN CTFPALIEDW 
       310        320        330        340        350        360 
RETFHRGSQG QTERFFPFGL VQLSSDLSKK SSDDGFPQIR WHQTADFGYV PNPKMPNTFM 
       370        380        390        400        410        420 
AVAMDLCDRD SPFGSIHPRD KQTVAYRLHL GARALAYGEK NLTFEGPLPE KIELLAHKGL 
       430        440        450        460        470        480 
LNLTYYQQIQ VQKKDNKIFE ISCCSDHRCK WLPASMNTVS TQSLTLAIDS CHGTVVALRY 
       490        500        510        520    
AWTTWPCEYK QCPLYHPSSA LPAPPFIAFI TDQGPGHQSN VAK

Isoforms

- Isoform 2 of Sialate O-acetylesterase

Sequence View

        10         20         30         40         50         60 
MVAPGLVLGL VLPLILWADR SAGIGFRFAS YINNDMVLQK EPAGAVIWGF GTPGATVTVT 
        70         80         90        100        110        120 
LRQGQETIMK KVTSVKAHSD TWMVVLDPMK PGGPFEVMAQ QTLEKINFTL RVHDVLFGDV 
       130        140        150        160        170        180 
WLCSGQSNMQ MTVLQIFNAT RELSNTAAYQ SVRILSVSPI QAEQELEDLV AVDLQWSKPT 
       190        200        210        220        230        240 
SENLGHGYFK YMSAVCWLFG RHLYDTLQYP IGLIASSWGG TPIEAWSSGR SLKACGVPKQ 
       250        260        270        280        290        300 
GSIPYDSVTG PSKHSVLWNA MIHPLCNMTL KGVVWYQGES NINYNTDLYN CTFPALIEDW 
       310        320        330        340        350        360 
RETFHRGSQG QTERFFPFGL VQLSSDLSKK SSDDGFPQIR WHQTADFGYV PNPKMPNTFM 
       370        380        390        400        410        420 
AVAMDLCDRD SPFGSIHPRD KQTVAYRLHL GARALAYGEK NLTFEGPLPE KIELLAHKGL 
       430        440        450        460        470        480 
LNLTYYQQIQ VQKKDNKIFE ISCCSDHRCK WLPASMNTVS TQSLTLAIDS CHGTVVALRY 
       490        500        510        520    
AWTTWPCEYK QCPLYHPSSA LPAPPFIAFI TDQGPGHQSN VAK



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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q9HAT2-24-unknown IGFRFA... 24 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q9HAT2-36-unknown MVLQKE... 36 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt89693

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...SNVAK 523 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...SNVAK 523 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt85311

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)