Q9HB75: p53-induced death domain-containing protein 1 {ECO:0000305}

General Information

Protein names	- p53-induced death domain-containing protein 1 {ECO:0000305} - 3.4.21.- {ECO:0000269\|PubMed:17159900} - Leucine-rich repeat and death domain-containing protein - PIDD-N {ECO:0000303\|PubMed:17159900} - PIDD-C {ECO:0000303\|PubMed:17159900} - PIDD-CC {ECO:0000303\|PubMed:17159900}
Gene names	PIDD
Organism	Homo sapiens
Protease Family	S68.001
Protease ID	S68.001
Chromosome location
UniProt ID	Q9HB75

8 N-termini

3 C-termini

2 Cleavages

9 Substrates

Sequence

Isoforms

- Isoform 2 of p53-induced protein with a death domain - Isoform 3 of p53-induced protein with a death domain - Isoform 4 of p53-induced protein with a death domain - Isoform 5 of p53-induced protein with a death domain - Isoform 6 of p53-induced protein with a death domain - Isoform 7 of p53-induced protein with a death domain - Isoform 2 of p53-induced death domain-containing protein 1 - Isoform 3 of p53-induced death domain-containing protein 1 - Isoform 4 of p53-induced death domain-containing protein 1 - Isoform 5 of p53-induced death domain-containing protein 1 - Isoform 6 of p53-induced death domain-containing protein 1 - Isoform 7 of p53-induced death domain-containing protein 1

Sequence View

        10         20         30         40         50         60
MAATVEGPEL EAAAAAGDAS EDSDAGSRAL PFLGGNRLSL DLYPGGCQQL LHLCVQQPLQ
        70         80         90        100        110        120
LLQVEFLRLS THEDPQLLEA TLAQLPQSLS CLRSLVLKGG QRRDTLGACL RGALTNLPAG
       130        140        150        160        170        180
LSGLAHLAHL DLSFNSLETL PACVLQMRGL GALLLSHNCL SELPEALGAL PALTFLTVTH
       190        200        210        220        230        240
NRLQTLPPAL GALSTLQRLD LSQNLLDTLP PEIGGLGSLL ELNLASNRLQ SLPASLAGLR
       250        260        270        280        290        300
SLRLLVLHSN LLASVPADLA RLPLLTRLDL RDNQLRDLPP ELLDAPFVRL QGNPLGEASP
       310        320        330        340        350        360
DAPSSPVAAL IPEMPRLFLT SDLDSFPVTP QGCSVTLACG VRLQFPAGAT ATPITIRYRL
       370        380        390        400        410        420
LLPEPGLVPL GPHDALLSHV LELQPHGVAF QQDVGLWLLF TPPQARRCRE VVVRTRNDNS
       430        440        450        460        470        480
WGDLETYLEE EAPQRLWAHC QVPHFSWFLV VSRPVSNACL VPPEGTLLCS SGHPGVKVIF
       490        500        510        520        530        540
PPGATEEPRR VSMQVVRMAG RELQALLGEP EAAVSPLLCL SQSGPPSFLQ PVTVQLPLPS
       550        560        570        580        590        600
GITGLSLDRS RLHLLYWAPP AATWDDITAQ VVLELTHLYA RFQVTHFSWY WLWYTTKNCV
       610        620        630        640        650        660
GGLARKAWER LRLHRVNLIA LQRRRDPEQV LLQCLPRNKV DATLRRLLER YRGPEPSDTV
       670        680        690        700        710        720
EMFEGEEFFA AFERGIDVDA DRPDCVEGRI CFVFYSHLKN VKEVYVTTTL DREAQAVRGQ
       730        740        750        760        770        780
VSFYRGAVPV RVPEEAEAAR QRKGADALWM ATLPIKLPRL RGSEGPRRGA GLSLAPLNLG
       790        800        810        820        830        840
DAETGFLTQS NLLSVAGRLG LDWPAVALHL GVSYREVQRI RHEFRDDLDE QIRHMLFSWA
       850        860        870        880        890        900
ERQAGQPGAV GLLVQALEQS DRQDVAEEVR AVLELGRRKY QDSIRRMGLA PKDPALPGSS
       910
APQPPEPAQA         10         20         30         40         50         60
MAATVEGPEL EAAAAAGDAS EDSDAGSRAL PFLGGNRLSL DLYPGGCQQL LHLCVQQPLQ
        70         80         90        100        110        120
LLQVEFLRLS THEDPQLLEA TLAQLPQSLS CLRSLVLKGG QRRDTLGACL RGALTNLPAG
       130        140        150        160        170        180
LSGLAHLAHL DLSFNSLETL PACVLQMRGL GALLLSHNCL SELPEALGAL PALTFLTVTH
       190        200        210        220        230        240
NRLQTLPPAL GALSTLQRLD LSQNLLDTLP PEIGGLGSLL ELNLASNRLQ SLPASLAGLR
       250        260        270        280        290        300
SLRLLVLHSN LLASVPADLA RLPLLTRLDL RDNQLRDLPP ELLDAPFVRL QGNPLGEASP
       310        320        330        340        350        360
DAPSSPVAAL IPEMPRLFLT SDLDSFPVTP QGCSVTLACG VRLQFPAGAT ATPITIRYRL
       370        380        390        400        410        420
LLPEPGLVPL GPHDALLSHV LELQPHGVAF QQDVGLWLLF TPPQARRCRE VVVRTRNDNS
       430        440        450        460        470        480
WGDLETYLEE EAPQRLWAHC QVPHFSWFLV VSRPVSNACL VPPEGTLLCS SGHPGVKVIF
       490        500        510        520        530        540
PPGATEEPRR VSMQVVRMAG RELQALLGEP EAAVSPLLCL SQSGPPSFLQ PVTVQLPLPS
       550        560        570        580        590        600
GITGLSLDRS RLHLLYWAPP AATWDDITAQ VVLELTHLYA RFQVTHFSWY WLWYTTKNCV
       610        620        630        640        650        660
GGLARKAWER LRLHRVNLIA LQRRRDPEQV LLQCLPRNKV DATLRRLLER YRGPEPSDTV
       670        680        690        700        710        720
EMFEGEEFFA AFERGIDVDA DRPDCVEGRI CFVFYSHLKN VKEVYVTTTL DREAQAVRGQ
       730        740        750        760        770        780
VSFYRGAVPV RVPEEAEAAR QRKGADALWM ATLPIKLPRL RGSEGPRRGA GLSLAPLNLG
       790        800        810        820        830        840
DAETGFLTQS NLLSVAGRLG LDWPAVALHL GVSYREVQRI RHEFRDDLDE QIRHMLFSWA
       850        860        870        880        890        900
ERQAGQPGAV GLLVQALEQS DRQDVAEEVR AVLELGRRKY QDSIRRMGLA PKDPALPGSS
       910
APQPPEPAQA         10         20         30         40         50         60
MAATVEGPEL EAAAAAGDAS EDSDAGSRAL PFLGGNRLSL DLYPGGCQQL LHLCVQQPLQ
        70         80         90        100        110        120
LLQVEFLRLS THEDPQLLEA TLAQLPQSLS CLRSLVLKGG QRRDTLGACL RGALTNLPAG
       130        140        150        160        170        180
LSGLAHLAHL DLSFNSLETL PACVLQMRGL GALLLSHNCL SELPEALGAL PALTFLTVTH
       190        200        210        220        230        240
NRLQTLPPAL GALSTLQRLD LSQNLLDTLP PEIGGLGSLL ELNLASNRLQ SLPASLAGLR
       250        260        270        280        290        300
SLRLLVLHSN LLASVPADLA RLPLLTRLDL RDNQLRDLPP ELLDAPFVRL QGNPLGEASP
       310        320        330        340        350        360
DAPSSPVAAL IPEMPRLFLT SDLDSFPVTP QGCSVTLACG VRLQFPAGAT ATPITIRYRL
       370        380        390        400        410        420
LLPEPGLVPL GPHDALLSHV LELQPHGVAF QQDVGLWLLF TPPQARRCRE VVVRTRNDNS
       430        440        450        460        470        480
WGDLETYLEE EAPQRLWAHC QVPHFSWFLV VSRPVSNACL VPPEGTLLCS SGHPGVKVIF
       490        500        510        520        530        540
PPGATEEPRR VSMQVVRMAG RELQALLGEP EAAVSPLLCL SQSGPPSFLQ PVTVQLPLPS
       550        560        570        580        590        600
GITGLSLDRS RLHLLYWAPP AATWDDITAQ VVLELTHLYA RFQVTHFSWY WLWYTTKNCV
       610        620        630        640        650        660
GGLARKAWER LRLHRVNLIA LQRRRDPEQV LLQCLPRNKV DATLRRLLER YRGPEPSDTV
       670        680        690        700        710        720
EMFEGEEFFA AFERGIDVDA DRPDCVEGRI CFVFYSHLKN VKEVYVTTTL DREAQAVRGQ
       730        740        750        760        770        780
VSFYRGAVPV RVPEEAEAAR QRKGADALWM ATLPIKLPRL RGSEGPRRGA GLSLAPLNLG
       790        800        810        820        830        840
DAETGFLTQS NLLSVAGRLG LDWPAVALHL GVSYREVQRI RHEFRDDLDE QIRHMLFSWA
       850        860        870        880        890        900
ERQAGQPGAV GLLVQALEQS DRQDVAEEVR AVLELGRRKY QDSIRRMGLA PKDPALPGSS
       910
APQPPEPAQA         10         20         30         40         50         60
MAATVEGPEL EAAAAAGDAS EDSDAGSRAL PFLGGNRLSL DLYPGGCQQL LHLCVQQPLQ
        70         80         90        100        110        120
LLQVEFLRLS THEDPQLLEA TLAQLPQSLS CLRSLVLKGG QRRDTLGACL RGALTNLPAG
       130        140        150        160        170        180
LSGLAHLAHL DLSFNSLETL PACVLQMRGL GALLLSHNCL SELPEALGAL PALTFLTVTH
       190        200        210        220        230        240
NRLQTLPPAL GALSTLQRLD LSQNLLDTLP PEIGGLGSLL ELNLASNRLQ SLPASLAGLR
       250        260        270        280        290        300
SLRLLVLHSN LLASVPADLA RLPLLTRLDL RDNQLRDLPP ELLDAPFVRL QGNPLGEASP
       310        320        330        340        350        360
DAPSSPVAAL IPEMPRLFLT SDLDSFPVTP QGCSVTLACG VRLQFPAGAT ATPITIRYRL
       370        380        390        400        410        420
LLPEPGLVPL GPHDALLSHV LELQPHGVAF QQDVGLWLLF TPPQARRCRE VVVRTRNDNS
       430        440        450        460        470        480
WGDLETYLEE EAPQRLWAHC QVPHFSWFLV VSRPVSNACL VPPEGTLLCS SGHPGVKVIF
       490        500        510        520        530        540
PPGATEEPRR VSMQVVRMAG RELQALLGEP EAAVSPLLCL SQSGPPSFLQ PVTVQLPLPS
       550        560        570        580        590        600
GITGLSLDRS RLHLLYWAPP AATWDDITAQ VVLELTHLYA RFQVTHFSWY WLWYTTKNCV
       610        620        630        640        650        660
GGLARKAWER LRLHRVNLIA LQRRRDPEQV LLQCLPRNKV DATLRRLLER YRGPEPSDTV
       670        680        690        700        710        720
EMFEGEEFFA AFERGIDVDA DRPDCVEGRI CFVFYSHLKN VKEVYVTTTL DREAQAVRGQ
       730        740        750        760        770        780
VSFYRGAVPV RVPEEAEAAR QRKGADALWM ATLPIKLPRL RGSEGPRRGA GLSLAPLNLG
       790        800        810        820        830        840
DAETGFLTQS NLLSVAGRLG LDWPAVALHL GVSYREVQRI RHEFRDDLDE QIRHMLFSWA
       850        860        870        880        890        900
ERQAGQPGAV GLLVQALEQS DRQDVAEEVR AVLELGRRKY QDSIRRMGLA PKDPALPGSS
       910
APQPPEPAQA         10         20         30         40         50         60
MAATVEGPEL EAAAAAGDAS EDSDAGSRAL PFLGGNRLSL DLYPGGCQQL LHLCVQQPLQ
        70         80         90        100        110        120
LLQVEFLRLS THEDPQLLEA TLAQLPQSLS CLRSLVLKGG QRRDTLGACL RGALTNLPAG
       130        140        150        160        170        180
LSGLAHLAHL DLSFNSLETL PACVLQMRGL GALLLSHNCL SELPEALGAL PALTFLTVTH
       190        200        210        220        230        240
NRLQTLPPAL GALSTLQRLD LSQNLLDTLP PEIGGLGSLL ELNLASNRLQ SLPASLAGLR
       250        260        270        280        290        300
SLRLLVLHSN LLASVPADLA RLPLLTRLDL RDNQLRDLPP ELLDAPFVRL QGNPLGEASP
       310        320        330        340        350        360
DAPSSPVAAL IPEMPRLFLT SDLDSFPVTP QGCSVTLACG VRLQFPAGAT ATPITIRYRL
       370        380        390        400        410        420
LLPEPGLVPL GPHDALLSHV LELQPHGVAF QQDVGLWLLF TPPQARRCRE VVVRTRNDNS
       430        440        450        460        470        480
WGDLETYLEE EAPQRLWAHC QVPHFSWFLV VSRPVSNACL VPPEGTLLCS SGHPGVKVIF
       490        500        510        520        530        540
PPGATEEPRR VSMQVVRMAG RELQALLGEP EAAVSPLLCL SQSGPPSFLQ PVTVQLPLPS
       550        560        570        580        590        600
GITGLSLDRS RLHLLYWAPP AATWDDITAQ VVLELTHLYA RFQVTHFSWY WLWYTTKNCV
       610        620        630        640        650        660
GGLARKAWER LRLHRVNLIA LQRRRDPEQV LLQCLPRNKV DATLRRLLER YRGPEPSDTV
       670        680        690        700        710        720
EMFEGEEFFA AFERGIDVDA DRPDCVEGRI CFVFYSHLKN VKEVYVTTTL DREAQAVRGQ
       730        740        750        760        770        780
VSFYRGAVPV RVPEEAEAAR QRKGADALWM ATLPIKLPRL RGSEGPRRGA GLSLAPLNLG
       790        800        810        820        830        840
DAETGFLTQS NLLSVAGRLG LDWPAVALHL GVSYREVQRI RHEFRDDLDE QIRHMLFSWA
       850        860        870        880        890        900
ERQAGQPGAV GLLVQALEQS DRQDVAEEVR AVLELGRRKY QDSIRRMGLA PKDPALPGSS
       910
APQPPEPAQA         10         20         30         40         50         60
MAATVEGPEL EAAAAAGDAS EDSDAGSRAL PFLGGNRLSL DLYPGGCQQL LHLCVQQPLQ
        70         80         90        100        110        120
LLQVEFLRLS THEDPQLLEA TLAQLPQSLS CLRSLVLKGG QRRDTLGACL RGALTNLPAG
       130        140        150        160        170        180
LSGLAHLAHL DLSFNSLETL PACVLQMRGL GALLLSHNCL SELPEALGAL PALTFLTVTH
       190        200        210        220        230        240
NRLQTLPPAL GALSTLQRLD LSQNLLDTLP PEIGGLGSLL ELNLASNRLQ SLPASLAGLR
       250        260        270        280        290        300
SLRLLVLHSN LLASVPADLA RLPLLTRLDL RDNQLRDLPP ELLDAPFVRL QGNPLGEASP
       310        320        330        340        350        360
DAPSSPVAAL IPEMPRLFLT SDLDSFPVTP QGCSVTLACG VRLQFPAGAT ATPITIRYRL
       370        380        390        400        410        420
LLPEPGLVPL GPHDALLSHV LELQPHGVAF QQDVGLWLLF TPPQARRCRE VVVRTRNDNS
       430        440        450        460        470        480
WGDLETYLEE EAPQRLWAHC QVPHFSWFLV VSRPVSNACL VPPEGTLLCS SGHPGVKVIF
       490        500        510        520        530        540
PPGATEEPRR VSMQVVRMAG RELQALLGEP EAAVSPLLCL SQSGPPSFLQ PVTVQLPLPS
       550        560        570        580        590        600
GITGLSLDRS RLHLLYWAPP AATWDDITAQ VVLELTHLYA RFQVTHFSWY WLWYTTKNCV
       610        620        630        640        650        660
GGLARKAWER LRLHRVNLIA LQRRRDPEQV LLQCLPRNKV DATLRRLLER YRGPEPSDTV
       670        680        690        700        710        720
EMFEGEEFFA AFERGIDVDA DRPDCVEGRI CFVFYSHLKN VKEVYVTTTL DREAQAVRGQ
       730        740        750        760        770        780
VSFYRGAVPV RVPEEAEAAR QRKGADALWM ATLPIKLPRL RGSEGPRRGA GLSLAPLNLG
       790        800        810        820        830        840
DAETGFLTQS NLLSVAGRLG LDWPAVALHL GVSYREVQRI RHEFRDDLDE QIRHMLFSWA
       850        860        870        880        890        900
ERQAGQPGAV GLLVQALEQS DRQDVAEEVR AVLELGRRKY QDSIRRMGLA PKDPALPGSS
       910
APQPPEPAQA         10         20         30         40         50         60
MAATVEGPEL EAAAAAGDAS EDSDAGSRAL PFLGGNRLSL DLYPGGCQQL LHLCVQQPLQ
        70         80         90        100        110        120
LLQVEFLRLS THEDPQLLEA TLAQLPQSLS CLRSLVLKGG QRRDTLGACL RGALTNLPAG
       130        140        150        160        170        180
LSGLAHLAHL DLSFNSLETL PACVLQMRGL GALLLSHNCL SELPEALGAL PALTFLTVTH
       190        200        210        220        230        240
NRLQTLPPAL GALSTLQRLD LSQNLLDTLP PEIGGLGSLL ELNLASNRLQ SLPASLAGLR
       250        260        270        280        290        300
SLRLLVLHSN LLASVPADLA RLPLLTRLDL RDNQLRDLPP ELLDAPFVRL QGNPLGEASP
       310        320        330        340        350        360
DAPSSPVAAL IPEMPRLFLT SDLDSFPVTP QGCSVTLACG VRLQFPAGAT ATPITIRYRL
       370        380        390        400        410        420
LLPEPGLVPL GPHDALLSHV LELQPHGVAF QQDVGLWLLF TPPQARRCRE VVVRTRNDNS
       430        440        450        460        470        480
WGDLETYLEE EAPQRLWAHC QVPHFSWFLV VSRPVSNACL VPPEGTLLCS SGHPGVKVIF
       490        500        510        520        530        540
PPGATEEPRR VSMQVVRMAG RELQALLGEP EAAVSPLLCL SQSGPPSFLQ PVTVQLPLPS
       550        560        570        580        590        600
GITGLSLDRS RLHLLYWAPP AATWDDITAQ VVLELTHLYA RFQVTHFSWY WLWYTTKNCV
       610        620        630        640        650        660
GGLARKAWER LRLHRVNLIA LQRRRDPEQV LLQCLPRNKV DATLRRLLER YRGPEPSDTV
       670        680        690        700        710        720
EMFEGEEFFA AFERGIDVDA DRPDCVEGRI CFVFYSHLKN VKEVYVTTTL DREAQAVRGQ
       730        740        750        760        770        780
VSFYRGAVPV RVPEEAEAAR QRKGADALWM ATLPIKLPRL RGSEGPRRGA GLSLAPLNLG
       790        800        810        820        830        840
DAETGFLTQS NLLSVAGRLG LDWPAVALHL GVSYREVQRI RHEFRDDLDE QIRHMLFSWA
       850        860        870        880        890        900
ERQAGQPGAV GLLVQALEQS DRQDVAEEVR AVLELGRRKY QDSIRRMGLA PKDPALPGSS
       910
APQPPEPAQA         10         20         30         40         50         60
MAATVEGPEL EAAAAAGDAS EDSDAGSRAL PFLGGNRLSL DLYPGGCQQL LHLCVQQPLQ
        70         80         90        100        110        120
LLQVEFLRLS THEDPQLLEA TLAQLPQSLS CLRSLVLKGG QRRDTLGACL RGALTNLPAG
       130        140        150        160        170        180
LSGLAHLAHL DLSFNSLETL PACVLQMRGL GALLLSHNCL SELPEALGAL PALTFLTVTH
       190        200        210        220        230        240
NRLQTLPPAL GALSTLQRLD LSQNLLDTLP PEIGGLGSLL ELNLASNRLQ SLPASLAGLR
       250        260        270        280        290        300
SLRLLVLHSN LLASVPADLA RLPLLTRLDL RDNQLRDLPP ELLDAPFVRL QGNPLGEASP
       310        320        330        340        350        360
DAPSSPVAAL IPEMPRLFLT SDLDSFPVTP QGCSVTLACG VRLQFPAGAT ATPITIRYRL
       370        380        390        400        410        420
LLPEPGLVPL GPHDALLSHV LELQPHGVAF QQDVGLWLLF TPPQARRCRE VVVRTRNDNS
       430        440        450        460        470        480
WGDLETYLEE EAPQRLWAHC QVPHFSWFLV VSRPVSNACL VPPEGTLLCS SGHPGVKVIF
       490        500        510        520        530        540
PPGATEEPRR VSMQVVRMAG RELQALLGEP EAAVSPLLCL SQSGPPSFLQ PVTVQLPLPS
       550        560        570        580        590        600
GITGLSLDRS RLHLLYWAPP AATWDDITAQ VVLELTHLYA RFQVTHFSWY WLWYTTKNCV
       610        620        630        640        650        660
GGLARKAWER LRLHRVNLIA LQRRRDPEQV LLQCLPRNKV DATLRRLLER YRGPEPSDTV
       670        680        690        700        710        720
EMFEGEEFFA AFERGIDVDA DRPDCVEGRI CFVFYSHLKN VKEVYVTTTL DREAQAVRGQ
       730        740        750        760        770        780
VSFYRGAVPV RVPEEAEAAR QRKGADALWM ATLPIKLPRL RGSEGPRRGA GLSLAPLNLG
       790        800        810        820        830        840
DAETGFLTQS NLLSVAGRLG LDWPAVALHL GVSYREVQRI RHEFRDDLDE QIRHMLFSWA
       850        860        870        880        890        900
ERQAGQPGAV GLLVQALEQS DRQDVAEEVR AVLELGRRKY QDSIRRMGLA PKDPALPGSS
       910
APQPPEPAQA         10         20         30         40         50         60
MAATVEGPEL EAAAAAGDAS EDSDAGSRAL PFLGGNRLSL DLYPGGCQQL LHLCVQQPLQ
        70         80         90        100        110        120
LLQVEFLRLS THEDPQLLEA TLAQLPQSLS CLRSLVLKGG QRRDTLGACL RGALTNLPAG
       130        140        150        160        170        180
LSGLAHLAHL DLSFNSLETL PACVLQMRGL GALLLSHNCL SELPEALGAL PALTFLTVTH
       190        200        210        220        230        240
NRLQTLPPAL GALSTLQRLD LSQNLLDTLP PEIGGLGSLL ELNLASNRLQ SLPASLAGLR
       250        260        270        280        290        300
SLRLLVLHSN LLASVPADLA RLPLLTRLDL RDNQLRDLPP ELLDAPFVRL QGNPLGEASP
       310        320        330        340        350        360
DAPSSPVAAL IPEMPRLFLT SDLDSFPVTP QGCSVTLACG VRLQFPAGAT ATPITIRYRL
       370        380        390        400        410        420
LLPEPGLVPL GPHDALLSHV LELQPHGVAF QQDVGLWLLF TPPQARRCRE VVVRTRNDNS
       430        440        450        460        470        480
WGDLETYLEE EAPQRLWAHC QVPHFSWFLV VSRPVSNACL VPPEGTLLCS SGHPGVKVIF
       490        500        510        520        530        540
PPGATEEPRR VSMQVVRMAG RELQALLGEP EAAVSPLLCL SQSGPPSFLQ PVTVQLPLPS
       550        560        570        580        590        600
GITGLSLDRS RLHLLYWAPP AATWDDITAQ VVLELTHLYA RFQVTHFSWY WLWYTTKNCV
       610        620        630        640        650        660
GGLARKAWER LRLHRVNLIA LQRRRDPEQV LLQCLPRNKV DATLRRLLER YRGPEPSDTV
       670        680        690        700        710        720
EMFEGEEFFA AFERGIDVDA DRPDCVEGRI CFVFYSHLKN VKEVYVTTTL DREAQAVRGQ
       730        740        750        760        770        780
VSFYRGAVPV RVPEEAEAAR QRKGADALWM ATLPIKLPRL RGSEGPRRGA GLSLAPLNLG
       790        800        810        820        830        840
DAETGFLTQS NLLSVAGRLG LDWPAVALHL GVSYREVQRI RHEFRDDLDE QIRHMLFSWA
       850        860        870        880        890        900
ERQAGQPGAV GLLVQALEQS DRQDVAEEVR AVLELGRRKY QDSIRRMGLA PKDPALPGSS
       910
APQPPEPAQA         10         20         30         40         50         60
MAATVEGPEL EAAAAAGDAS EDSDAGSRAL PFLGGNRLSL DLYPGGCQQL LHLCVQQPLQ
        70         80         90        100        110        120
LLQVEFLRLS THEDPQLLEA TLAQLPQSLS CLRSLVLKGG QRRDTLGACL RGALTNLPAG
       130        140        150        160        170        180
LSGLAHLAHL DLSFNSLETL PACVLQMRGL GALLLSHNCL SELPEALGAL PALTFLTVTH
       190        200        210        220        230        240
NRLQTLPPAL GALSTLQRLD LSQNLLDTLP PEIGGLGSLL ELNLASNRLQ SLPASLAGLR
       250        260        270        280        290        300
SLRLLVLHSN LLASVPADLA RLPLLTRLDL RDNQLRDLPP ELLDAPFVRL QGNPLGEASP
       310        320        330        340        350        360
DAPSSPVAAL IPEMPRLFLT SDLDSFPVTP QGCSVTLACG VRLQFPAGAT ATPITIRYRL
       370        380        390        400        410        420
LLPEPGLVPL GPHDALLSHV LELQPHGVAF QQDVGLWLLF TPPQARRCRE VVVRTRNDNS
       430        440        450        460        470        480
WGDLETYLEE EAPQRLWAHC QVPHFSWFLV VSRPVSNACL VPPEGTLLCS SGHPGVKVIF
       490        500        510        520        530        540
PPGATEEPRR VSMQVVRMAG RELQALLGEP EAAVSPLLCL SQSGPPSFLQ PVTVQLPLPS
       550        560        570        580        590        600
GITGLSLDRS RLHLLYWAPP AATWDDITAQ VVLELTHLYA RFQVTHFSWY WLWYTTKNCV
       610        620        630        640        650        660
GGLARKAWER LRLHRVNLIA LQRRRDPEQV LLQCLPRNKV DATLRRLLER YRGPEPSDTV
       670        680        690        700        710        720
EMFEGEEFFA AFERGIDVDA DRPDCVEGRI CFVFYSHLKN VKEVYVTTTL DREAQAVRGQ
       730        740        750        760        770        780
VSFYRGAVPV RVPEEAEAAR QRKGADALWM ATLPIKLPRL RGSEGPRRGA GLSLAPLNLG
       790        800        810        820        830        840
DAETGFLTQS NLLSVAGRLG LDWPAVALHL GVSYREVQRI RHEFRDDLDE QIRHMLFSWA
       850        860        870        880        890        900
ERQAGQPGAV GLLVQALEQS DRQDVAEEVR AVLELGRRKY QDSIRRMGLA PKDPALPGSS
       910
APQPPEPAQA         10         20         30         40         50         60
MAATVEGPEL EAAAAAGDAS EDSDAGSRAL PFLGGNRLSL DLYPGGCQQL LHLCVQQPLQ
        70         80         90        100        110        120
LLQVEFLRLS THEDPQLLEA TLAQLPQSLS CLRSLVLKGG QRRDTLGACL RGALTNLPAG
       130        140        150        160        170        180
LSGLAHLAHL DLSFNSLETL PACVLQMRGL GALLLSHNCL SELPEALGAL PALTFLTVTH
       190        200        210        220        230        240
NRLQTLPPAL GALSTLQRLD LSQNLLDTLP PEIGGLGSLL ELNLASNRLQ SLPASLAGLR
       250        260        270        280        290        300
SLRLLVLHSN LLASVPADLA RLPLLTRLDL RDNQLRDLPP ELLDAPFVRL QGNPLGEASP
       310        320        330        340        350        360
DAPSSPVAAL IPEMPRLFLT SDLDSFPVTP QGCSVTLACG VRLQFPAGAT ATPITIRYRL
       370        380        390        400        410        420
LLPEPGLVPL GPHDALLSHV LELQPHGVAF QQDVGLWLLF TPPQARRCRE VVVRTRNDNS
       430        440        450        460        470        480
WGDLETYLEE EAPQRLWAHC QVPHFSWFLV VSRPVSNACL VPPEGTLLCS SGHPGVKVIF
       490        500        510        520        530        540
PPGATEEPRR VSMQVVRMAG RELQALLGEP EAAVSPLLCL SQSGPPSFLQ PVTVQLPLPS
       550        560        570        580        590        600
GITGLSLDRS RLHLLYWAPP AATWDDITAQ VVLELTHLYA RFQVTHFSWY WLWYTTKNCV
       610        620        630        640        650        660
GGLARKAWER LRLHRVNLIA LQRRRDPEQV LLQCLPRNKV DATLRRLLER YRGPEPSDTV
       670        680        690        700        710        720
EMFEGEEFFA AFERGIDVDA DRPDCVEGRI CFVFYSHLKN VKEVYVTTTL DREAQAVRGQ
       730        740        750        760        770        780
VSFYRGAVPV RVPEEAEAAR QRKGADALWM ATLPIKLPRL RGSEGPRRGA GLSLAPLNLG
       790        800        810        820        830        840
DAETGFLTQS NLLSVAGRLG LDWPAVALHL GVSYREVQRI RHEFRDDLDE QIRHMLFSWA
       850        860        870        880        890        900
ERQAGQPGAV GLLVQALEQS DRQDVAEEVR AVLELGRRKY QDSIRRMGLA PKDPALPGSS
       910
APQPPEPAQA         10         20         30         40         50         60
MAATVEGPEL EAAAAAGDAS EDSDAGSRAL PFLGGNRLSL DLYPGGCQQL LHLCVQQPLQ
        70         80         90        100        110        120
LLQVEFLRLS THEDPQLLEA TLAQLPQSLS CLRSLVLKGG QRRDTLGACL RGALTNLPAG
       130        140        150        160        170        180
LSGLAHLAHL DLSFNSLETL PACVLQMRGL GALLLSHNCL SELPEALGAL PALTFLTVTH
       190        200        210        220        230        240
NRLQTLPPAL GALSTLQRLD LSQNLLDTLP PEIGGLGSLL ELNLASNRLQ SLPASLAGLR
       250        260        270        280        290        300
SLRLLVLHSN LLASVPADLA RLPLLTRLDL RDNQLRDLPP ELLDAPFVRL QGNPLGEASP
       310        320        330        340        350        360
DAPSSPVAAL IPEMPRLFLT SDLDSFPVTP QGCSVTLACG VRLQFPAGAT ATPITIRYRL
       370        380        390        400        410        420
LLPEPGLVPL GPHDALLSHV LELQPHGVAF QQDVGLWLLF TPPQARRCRE VVVRTRNDNS
       430        440        450        460        470        480
WGDLETYLEE EAPQRLWAHC QVPHFSWFLV VSRPVSNACL VPPEGTLLCS SGHPGVKVIF
       490        500        510        520        530        540
PPGATEEPRR VSMQVVRMAG RELQALLGEP EAAVSPLLCL SQSGPPSFLQ PVTVQLPLPS
       550        560        570        580        590        600
GITGLSLDRS RLHLLYWAPP AATWDDITAQ VVLELTHLYA RFQVTHFSWY WLWYTTKNCV
       610        620        630        640        650        660
GGLARKAWER LRLHRVNLIA LQRRRDPEQV LLQCLPRNKV DATLRRLLER YRGPEPSDTV
       670        680        690        700        710        720
EMFEGEEFFA AFERGIDVDA DRPDCVEGRI CFVFYSHLKN VKEVYVTTTL DREAQAVRGQ
       730        740        750        760        770        780
VSFYRGAVPV RVPEEAEAAR QRKGADALWM ATLPIKLPRL RGSEGPRRGA GLSLAPLNLG
       790        800        810        820        830        840
DAETGFLTQS NLLSVAGRLG LDWPAVALHL GVSYREVQRI RHEFRDDLDE QIRHMLFSWA
       850        860        870        880        890        900
ERQAGQPGAV GLLVQALEQS DRQDVAEEVR AVLELGRRKY QDSIRRMGLA PKDPALPGSS
       910
APQPPEPAQA

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

8 N-termini - 3 C-termini - 2 Cleavages - 9 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
Q9HB75-1-unknown	MAATVE...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt85174
Q9HB75-2-unknown	MAATVE...	1		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9HB75-2-Acetylation	AATVEG...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9HB75-2-Acetylation	AATVEG...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt110944
Q9HB75-147-unknown	MRGLGA...	147		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt85175
Q9HB75-147-unknown	MRGLGA...	147		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt106112
Q9HB75-314-unknown	MPRLFL...	314		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt85176
Q9HB75-314-unknown	MPRLFL...	314		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt85177
Q9HB75-314-unknown	MPRLFL...	314		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt85179
Q9HB75-314-unknown	MPRLFL...	314		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt106155
Q9HB75-314-unknown	MPRLFL...	314		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt106156
Q9HB75-446-unknown	SWFLVV...	446		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27416
Q9HB75-446-unknown	SWFLVV...	446		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143991
Q9HB75-446-unknown	SWFLVV...	446		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143992
Q9HB75-446-unknown	SWFLVV...	446		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143993
Q9HB75-446-unknown	SWFLVV...	446		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149848
Q9HB75-446-unknown	SWFLVV...	446		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152730
Q9HB75-446-unknown	SWFLVV...	446		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9HB75-493-unknown	MQVVRM...	493		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt85178
Q9HB75-493-unknown	MQVVRM...	493		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt106295
Q9HB75-493-unknown	MQVVRM...	493		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt106296
Q9HB75-493-unknown	MQVVRM...	493		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt106297
Q9HB75-493-unknown	MQVVRM...	493		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt106298
Q9HB75-493-unknown	MQVVRM...	493		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt106299
Q9HB75-588-unknown	SWYWLW...	588		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27422
Q9HB75-588-unknown	SWYWLW...	588		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149228
Q9HB75-588-unknown	SWYWLW...	588		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt154424

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QVPHFS	445	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27416
...QVPHFS	445	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127234
...QVPHFS	445	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127235
...QVPHFS	445	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127236
...QVPHFS	445	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...QVPHFS	445	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133239
...QVPHFS	445	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136150
...QVTHFS	587	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27422
...QVTHFS	587	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132613
...QVTHFS	587	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137845
...EPAQA	910	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...EPAQA	910	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt80794
...EPAQA	910	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt80793
...EPAQA	910	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt80792

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
PIDD1_HUMAN	445	PHFS.\|.SWFL	inferred from experiment	unknown	MEROPS	Tschopp J	Tinel A et al.:Autoproteolysis of PIDD marks t... (S68.001)	17159900,
PIDD1_HUMAN	587	THFS.\|.SWYW	inferred from experiment	unknown	MEROPS	Tschopp J	Tinel A et al.:Autoproteolysis of PIDD marks t... (S68.001)	17159900,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
PIDD-Isoform7_HUMAN	132	PHFS.\|.SWFL	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27416
PIDD-Isoform5_HUMAN	132	PHFS.\|.SWFL	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27416
PIDD-Isoform4_HUMAN	132	PHFS.\|.SWFL	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27416
PIDD-Isoform4_HUMAN	274	THFS.\|.SWYW	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27422
PIDD-Isoform3_HUMAN	299	PHFS.\|.SWFL	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27416
PIDD1_HUMAN	445	PHFS.\|.SWFL	inferred from experiment	unknown	MEROPS	Tschopp J	Tinel A et al.:Autoproteolysis of PIDD marks t... (S68.001)	17159900,
PIDD-Isoform2_HUMAN	445	PHFS.\|.SWFL	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27416
PIDD1_HUMAN	587	THFS.\|.SWYW	inferred from experiment	unknown	MEROPS	Tschopp J	Tinel A et al.:Autoproteolysis of PIDD marks t... (S68.001)	17159900,
PIDD-Isoform2_HUMAN	587	THFS.\|.SWYW	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27422