TopFIND 4.0

Q9HCI7: E3 ubiquitin-protein ligase MSL2

General Information

Protein names
- E3 ubiquitin-protein ligase MSL2
- 2.3.2.-
- E3 ubiquitin-protein transferase MSL2 {ECO:0000305}
- Male-specific lethal 2-like 1
- MSL2-like 1
- Male-specific lethal-2 homolog
- MSL-2
- Male-specific lethal-2 homolog 1
- RING finger protein 184
Gene names MSL2
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q9HCI7

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MNPVNATALY ISASRLVLNY DPGDPKAFTE INRLLPYFRQ SLSCCVCGHL LQDPIAPTNS 
        70         80         90        100        110        120 
TCQHYVCKTC KGKKMMMKPS CSWCKDYEQF EENKQLSILV NCYKKLCEYI TQTTLARDII 
       130        140        150        160        170        180 
EAVDCSSDIL ALLNDGSLFC EETEKPSDSS FTLCLTHSPL PSTSEPTTDP QASLSPMSES 
       190        200        210        220        230        240 
TLSIAIGSSV INGLPTYNGL SIDRFGINIP SPEHSNTIDV CNTVDIKTED LSDSLPPVCD 
       250        260        270        280        290        300 
TVATDLCSTG IDICSFSEDI KPGDSLLLSV EEVLRSLETV SNTEVCCPNL QPNLEATVSN 
       310        320        330        340        350        360 
GPFLQLSSQS LSHNVFMSTS PALHGLSCTA ATPKIAKLNR KRSRSESDSE KVQPLPISTI 
       370        380        390        400        410        420 
IRGPTLGASA PVTVKRESKI SLQPIATVPN GGTTPKISKT VLLSTKSMKK SHEHGSKKSH 
       430        440        450        460        470        480 
SKTKPGILKK DKAVKEKIPS HHFMPGSPTK TVYKKPQEKK GCKCGRATQN PSVLTCRGQR 
       490        500        510        520        530        540 
CPCYSNRKAC LDCICRGCQN SYMANGEKKL EAFAVPEKAL EQTRLTLGIN VTSIAVRNAS 
       550        560        570    
TSTSVINVTG SPVTTFLAAS THDDKSLDEA IDMRFDC

Isoforms

- Isoform 2 of E3 ubiquitin-protein ligase MSL2

Sequence View

        10         20         30         40         50         60 
MNPVNATALY ISASRLVLNY DPGDPKAFTE INRLLPYFRQ SLSCCVCGHL LQDPIAPTNS 
        70         80         90        100        110        120 
TCQHYVCKTC KGKKMMMKPS CSWCKDYEQF EENKQLSILV NCYKKLCEYI TQTTLARDII 
       130        140        150        160        170        180 
EAVDCSSDIL ALLNDGSLFC EETEKPSDSS FTLCLTHSPL PSTSEPTTDP QASLSPMSES 
       190        200        210        220        230        240 
TLSIAIGSSV INGLPTYNGL SIDRFGINIP SPEHSNTIDV CNTVDIKTED LSDSLPPVCD 
       250        260        270        280        290        300 
TVATDLCSTG IDICSFSEDI KPGDSLLLSV EEVLRSLETV SNTEVCCPNL QPNLEATVSN 
       310        320        330        340        350        360 
GPFLQLSSQS LSHNVFMSTS PALHGLSCTA ATPKIAKLNR KRSRSESDSE KVQPLPISTI 
       370        380        390        400        410        420 
IRGPTLGASA PVTVKRESKI SLQPIATVPN GGTTPKISKT VLLSTKSMKK SHEHGSKKSH 
       430        440        450        460        470        480 
SKTKPGILKK DKAVKEKIPS HHFMPGSPTK TVYKKPQEKK GCKCGRATQN PSVLTCRGQR 
       490        500        510        520        530        540 
CPCYSNRKAC LDCICRGCQN SYMANGEKKL EAFAVPEKAL EQTRLTLGIN VTSIAVRNAS 
       550        560        570    
TSTSVINVTG SPVTTFLAAS THDDKSLDEA IDMRFDC



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(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q9HCI7-1-unknown MNPVNA... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q9HCI7-75-unknown MMMKPS... 75 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt81625

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...MRFDC 577 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...MRFDC 577 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt77243

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)