TopFIND 4.0

Q9JLV6: Bifunctional polynucleotide phosphatase/kinase

General Information

Protein names
- Bifunctional polynucleotide phosphatase/kinase
- DNA 5'-kinase/3'-phosphatase
- Polynucleotide kinase-3'-phosphatase
- Polynucleotide 3'-phosphatase
- 3.1.3.32
- 2'(3')-polynucleotidase
- Polynucleotide 5'-hydroxyl-kinase
- 2.7.1.78
Gene names Pnkp
Organism Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID Q9JLV6

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MSQLGSRGRL WLQSPTGGPP PIFLPSDGQA LVLGRGPLTQ VTDRKCSRNQ VELIADPESR 
        70         80         90        100        110        120 
TVAVKQLGVN PSTVGVHELK PGLSGSLSLG DVLYLVNGLY PLTLRWEELS TSGSQPDAPP 
       130        140        150        160        170        180 
DTPGDPEEGE DTEPQKKRVR KSSLGWESLK KLLVFTASGV KPQGKVAAFD LDGTLITTRS 
       190        200        210        220        230        240 
GKVFPTSPSD WRILYPEIPK KLQELAAEGY KLVIFTNQMG IGRGKLPAEV FKGKVEAVLE 
       250        260        270        280        290        300 
KLGVPFQVLV ATHAGLNRKP VSGMWDHLQE QANEGIPISV EDSVFVGDAA GRLANWAPGR 
       310        320        330        340        350        360 
KKKDFSCADR LFALNVGLPF ATPEEFFLKW PAARFELPAF DPRTISSAGP LYLPESSSLL 
       370        380        390        400        410        420 
SPNPEVVVAV GFPGAGKSTF IQEHLVSAGY VHVNRDTLGS WQRCVSSCQA ALRQGKRVVI 
       430        440        450        460        470        480 
DNTNPDVPSR ARYIQCAKDA GVPCRCFNFC ATIEQARHNN RFREMTDPSH APVSDMVMFS 
       490        500        510        520    
YRKQFEPPTL AEGFLEILEI PFRLQEHLDP ALQRLYRQFS EG

Isoforms

- Isoform 2 of Bifunctional polynucleotide phosphatase/kinase

Sequence View

        10         20         30         40         50         60 
MSQLGSRGRL WLQSPTGGPP PIFLPSDGQA LVLGRGPLTQ VTDRKCSRNQ VELIADPESR 
        70         80         90        100        110        120 
TVAVKQLGVN PSTVGVHELK PGLSGSLSLG DVLYLVNGLY PLTLRWEELS TSGSQPDAPP 
       130        140        150        160        170        180 
DTPGDPEEGE DTEPQKKRVR KSSLGWESLK KLLVFTASGV KPQGKVAAFD LDGTLITTRS 
       190        200        210        220        230        240 
GKVFPTSPSD WRILYPEIPK KLQELAAEGY KLVIFTNQMG IGRGKLPAEV FKGKVEAVLE 
       250        260        270        280        290        300 
KLGVPFQVLV ATHAGLNRKP VSGMWDHLQE QANEGIPISV EDSVFVGDAA GRLANWAPGR 
       310        320        330        340        350        360 
KKKDFSCADR LFALNVGLPF ATPEEFFLKW PAARFELPAF DPRTISSAGP LYLPESSSLL 
       370        380        390        400        410        420 
SPNPEVVVAV GFPGAGKSTF IQEHLVSAGY VHVNRDTLGS WQRCVSSCQA ALRQGKRVVI 
       430        440        450        460        470        480 
DNTNPDVPSR ARYIQCAKDA GVPCRCFNFC ATIEQARHNN RFREMTDPSH APVSDMVMFS 
       490        500        510        520    
YRKQFEPPTL AEGFLEILEI PFRLQEHLDP ALQRLYRQFS EG



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(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


Database:


Lab:



Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q9JLV6-1-unknown MSQLGS... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt85698
    Q9JLV6-1-Acetylation MSQLGS... 1 acetylation- inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q9JLV6-1-Acetylation MSQLGS... 1 acetylation- inferred from isoform by sequence similarity unknown TopFIND inferred from TNt99912

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...QFSEG 522 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...QFSEG 522 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt81316

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)