Q9NP80: Calcium-independent phospholipase A2-gamma

General Information

Protein names	- Calcium-independent phospholipase A2-gamma - 3.1.1.5 - Intracellular membrane-associated calcium-independent phospholipase A2 gamma - iPLA2-gamma - PNPLA-gamma - Patatin-like phospholipase domain-containing protein 8 - iPLA2-2
Gene names	PNPLA8
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9NP80

2 N-termini

4 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Calcium-independent phospholipase A2-gamma - Isoform 3 of Calcium-independent phospholipase A2-gamma

Sequence View

        10         20         30         40         50         60
MSINLTVDIY IYLLSNARSV CGKQRSKQLY FLFSPKHYWR ISHISLQRGF HTNIIRCKWT
        70         80         90        100        110        120
KSEAHSCSKH CYSPSNHGLH IGILKLSTSA PKGLTKVNIC MSRIKSTLNS VSKAVFGNQN
       130        140        150        160        170        180
EMISRLAQFK PSSQILRKVS DSGWLKQKNI KQAIKSLKKY SDKSAEKSPF PEEKSHIIDK
       190        200        210        220        230        240
EEDIGKRSLF HYTSSITTKF GDSFYFLSNH INSYFKRKEK MSQQKENEHF RDKSELEDKK
       250        260        270        280        290        300
VEEGKLRSPD PGILAYKPGS ESVHTVDKPT SPSAIPDVLQ VSTKQSIANF LSRPTEGVQA
       310        320        330        340        350        360
LVGGYIGGLV PKLKYDSKSQ SEEQEEPAKT DQAVSKDRNA EEKKRLSLQR EKIIARVSID
       370        380        390        400        410        420
NRTRALVQAL RRTTDPKLCI TRVEELTFHL LEFPEGKGVA VKERIIPYLL RLRQIKDETL
       430        440        450        460        470        480
QAAVREILAL IGYVDPVKGR GIRILSIDGG GTRGVVALQT LRKLVELTQK PVHQLFDYIC
       490        500        510        520        530        540
GVSTGAILAF MLGLFHMPLD ECEELYRKLG SDVFSQNVIV GTVKMSWSHA FYDSQTWENI
       550        560        570        580        590        600
LKDRMGSALM IETARNPTCP KVAAVSTIVN RGITPKAFVF RNYGHFPGIN SHYLGGCQYK
       610        620        630        640        650        660
MWQAIRASSA APGYFAEYAL GNDLHQDGGL LLNNPSALAM HECKCLWPDV PLECIVSLGT
       670        680        690        700        710        720
GRYESDVRNT VTYTSLKTKL SNVINSATDT EEVHIMLDGL LPPDTYFRFN PVMCENIPLD
       730        740        750        760        770        780
ESRNEKLDQL QLEGLKYIER NEQKMKKVAK ILSQEKTTLQ KINDWIKLKT DMYEGLPFFS

KL         10         20         30         40         50         60
MSINLTVDIY IYLLSNARSV CGKQRSKQLY FLFSPKHYWR ISHISLQRGF HTNIIRCKWT
        70         80         90        100        110        120
KSEAHSCSKH CYSPSNHGLH IGILKLSTSA PKGLTKVNIC MSRIKSTLNS VSKAVFGNQN
       130        140        150        160        170        180
EMISRLAQFK PSSQILRKVS DSGWLKQKNI KQAIKSLKKY SDKSAEKSPF PEEKSHIIDK
       190        200        210        220        230        240
EEDIGKRSLF HYTSSITTKF GDSFYFLSNH INSYFKRKEK MSQQKENEHF RDKSELEDKK
       250        260        270        280        290        300
VEEGKLRSPD PGILAYKPGS ESVHTVDKPT SPSAIPDVLQ VSTKQSIANF LSRPTEGVQA
       310        320        330        340        350        360
LVGGYIGGLV PKLKYDSKSQ SEEQEEPAKT DQAVSKDRNA EEKKRLSLQR EKIIARVSID
       370        380        390        400        410        420
NRTRALVQAL RRTTDPKLCI TRVEELTFHL LEFPEGKGVA VKERIIPYLL RLRQIKDETL
       430        440        450        460        470        480
QAAVREILAL IGYVDPVKGR GIRILSIDGG GTRGVVALQT LRKLVELTQK PVHQLFDYIC
       490        500        510        520        530        540
GVSTGAILAF MLGLFHMPLD ECEELYRKLG SDVFSQNVIV GTVKMSWSHA FYDSQTWENI
       550        560        570        580        590        600
LKDRMGSALM IETARNPTCP KVAAVSTIVN RGITPKAFVF RNYGHFPGIN SHYLGGCQYK
       610        620        630        640        650        660
MWQAIRASSA APGYFAEYAL GNDLHQDGGL LLNNPSALAM HECKCLWPDV PLECIVSLGT
       670        680        690        700        710        720
GRYESDVRNT VTYTSLKTKL SNVINSATDT EEVHIMLDGL LPPDTYFRFN PVMCENIPLD
       730        740        750        760        770        780
ESRNEKLDQL QLEGLKYIER NEQKMKKVAK ILSQEKTTLQ KINDWIKLKT DMYEGLPFFS

KL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 4 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9NP80-1-unknown	MSINLT...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9NP80-1-unknown	MSINLT...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt85607
Q9NP80-101-unknown	MSRIKS...	101	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt85608
Q9NP80-101-unknown	MSRIKS...	101	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000387789
Q9NP80-101-unknown	MSRIKS...	101	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000402274
Q9NP80-101-unknown	MSRIKS...	101	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt101815

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...HTNIIR	55	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000391872
...HTNIIR	55	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153923
...SLFHYT	192	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000406033
...SLFHYT	192	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155533
...SLFHYT	192	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155534
...LKYIER	739	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000402274
...FFSKL	782	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...FFSKL	782	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt81226
...FFSKL	782	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt81225

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)