Q9NPH5: NADPH oxidase 4

General Information

Protein names	- NADPH oxidase 4 - 1.6.3.- - Kidney oxidase-1 - KOX-1 - Kidney superoxide-producing NADPH oxidase - Renal NAD(P)H-oxidase
Gene names	NOX4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9NPH5

4 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of NADPH oxidase 4 - Isoform 3 of NADPH oxidase 4 - Isoform 4 of NADPH oxidase 4 - Isoform 5 of NADPH oxidase 4 - Isoform 6 of NADPH oxidase 4 - Isoform 7 of NADPH oxidase 4 - Isoform 8 of NADPH oxidase 4 - Isoform 9 of NADPH oxidase 4

Sequence View

        10         20         30         40         50         60
MAVSWRSWLA NEGVKHLCLF IWLSMNVLLF WKTFLLYNQG PEYHYLHQML GLGLCLSRAS
        70         80         90        100        110        120
ASVLNLNCSL ILLPMCRTLL AYLRGSQKVP SRRTRRLLDK SRTFHITCGV TICIFSGVHV
       130        140        150        160        170        180
AAHLVNALNF SVNYSEDFVE LNAARYRDED PRKLLFTTVP GLTGVCMVVV LFLMITASTY
       190        200        210        220        230        240
AIRVSNYDIF WYTHNLFFVF YMLLTLHVSG GLLKYQTNLD THPPGCISLN RTSSQNISLP
       250        260        270        280        290        300
EYFSEHFHEP FPEGFSKPAE FTQHKFVKIC MEEPRFQANF PQTWLWISGP LCLYCAERLY
       310        320        330        340        350        360
RYIRSNKPVT IISVMSHPSD VMEIRMVKEN FKARPGQYIT LHCPSVSALE NHPFTLTMCP
       370        380        390        400        410        420
TETKATFGVH LKIVGDWTER FRDLLLPPSS QDSEILPFIQ SRNYPKLYID GPFGSPFEES
       430        440        450        460        470        480
LNYEVSLCVA GGIGVTPFAS ILNTLLDDWK PYKLRRLYFI WVCRDIQSFR WFADLLCMLH
       490        500        510        520        530        540
NKFWQENRPD YVNIQLYLSQ TDGIQKIIGE KYHALNSRLF IGRPRWKLLF DEIAKYNRGK
       550        560        570
TVGVFCCGPN SLSKTLHKLS NQNNSYGTRF EYNKESFS         10         20         30         40         50         60
MAVSWRSWLA NEGVKHLCLF IWLSMNVLLF WKTFLLYNQG PEYHYLHQML GLGLCLSRAS
        70         80         90        100        110        120
ASVLNLNCSL ILLPMCRTLL AYLRGSQKVP SRRTRRLLDK SRTFHITCGV TICIFSGVHV
       130        140        150        160        170        180
AAHLVNALNF SVNYSEDFVE LNAARYRDED PRKLLFTTVP GLTGVCMVVV LFLMITASTY
       190        200        210        220        230        240
AIRVSNYDIF WYTHNLFFVF YMLLTLHVSG GLLKYQTNLD THPPGCISLN RTSSQNISLP
       250        260        270        280        290        300
EYFSEHFHEP FPEGFSKPAE FTQHKFVKIC MEEPRFQANF PQTWLWISGP LCLYCAERLY
       310        320        330        340        350        360
RYIRSNKPVT IISVMSHPSD VMEIRMVKEN FKARPGQYIT LHCPSVSALE NHPFTLTMCP
       370        380        390        400        410        420
TETKATFGVH LKIVGDWTER FRDLLLPPSS QDSEILPFIQ SRNYPKLYID GPFGSPFEES
       430        440        450        460        470        480
LNYEVSLCVA GGIGVTPFAS ILNTLLDDWK PYKLRRLYFI WVCRDIQSFR WFADLLCMLH
       490        500        510        520        530        540
NKFWQENRPD YVNIQLYLSQ TDGIQKIIGE KYHALNSRLF IGRPRWKLLF DEIAKYNRGK
       550        560        570
TVGVFCCGPN SLSKTLHKLS NQNNSYGTRF EYNKESFS         10         20         30         40         50         60
MAVSWRSWLA NEGVKHLCLF IWLSMNVLLF WKTFLLYNQG PEYHYLHQML GLGLCLSRAS
        70         80         90        100        110        120
ASVLNLNCSL ILLPMCRTLL AYLRGSQKVP SRRTRRLLDK SRTFHITCGV TICIFSGVHV
       130        140        150        160        170        180
AAHLVNALNF SVNYSEDFVE LNAARYRDED PRKLLFTTVP GLTGVCMVVV LFLMITASTY
       190        200        210        220        230        240
AIRVSNYDIF WYTHNLFFVF YMLLTLHVSG GLLKYQTNLD THPPGCISLN RTSSQNISLP
       250        260        270        280        290        300
EYFSEHFHEP FPEGFSKPAE FTQHKFVKIC MEEPRFQANF PQTWLWISGP LCLYCAERLY
       310        320        330        340        350        360
RYIRSNKPVT IISVMSHPSD VMEIRMVKEN FKARPGQYIT LHCPSVSALE NHPFTLTMCP
       370        380        390        400        410        420
TETKATFGVH LKIVGDWTER FRDLLLPPSS QDSEILPFIQ SRNYPKLYID GPFGSPFEES
       430        440        450        460        470        480
LNYEVSLCVA GGIGVTPFAS ILNTLLDDWK PYKLRRLYFI WVCRDIQSFR WFADLLCMLH
       490        500        510        520        530        540
NKFWQENRPD YVNIQLYLSQ TDGIQKIIGE KYHALNSRLF IGRPRWKLLF DEIAKYNRGK
       550        560        570
TVGVFCCGPN SLSKTLHKLS NQNNSYGTRF EYNKESFS         10         20         30         40         50         60
MAVSWRSWLA NEGVKHLCLF IWLSMNVLLF WKTFLLYNQG PEYHYLHQML GLGLCLSRAS
        70         80         90        100        110        120
ASVLNLNCSL ILLPMCRTLL AYLRGSQKVP SRRTRRLLDK SRTFHITCGV TICIFSGVHV
       130        140        150        160        170        180
AAHLVNALNF SVNYSEDFVE LNAARYRDED PRKLLFTTVP GLTGVCMVVV LFLMITASTY
       190        200        210        220        230        240
AIRVSNYDIF WYTHNLFFVF YMLLTLHVSG GLLKYQTNLD THPPGCISLN RTSSQNISLP
       250        260        270        280        290        300
EYFSEHFHEP FPEGFSKPAE FTQHKFVKIC MEEPRFQANF PQTWLWISGP LCLYCAERLY
       310        320        330        340        350        360
RYIRSNKPVT IISVMSHPSD VMEIRMVKEN FKARPGQYIT LHCPSVSALE NHPFTLTMCP
       370        380        390        400        410        420
TETKATFGVH LKIVGDWTER FRDLLLPPSS QDSEILPFIQ SRNYPKLYID GPFGSPFEES
       430        440        450        460        470        480
LNYEVSLCVA GGIGVTPFAS ILNTLLDDWK PYKLRRLYFI WVCRDIQSFR WFADLLCMLH
       490        500        510        520        530        540
NKFWQENRPD YVNIQLYLSQ TDGIQKIIGE KYHALNSRLF IGRPRWKLLF DEIAKYNRGK
       550        560        570
TVGVFCCGPN SLSKTLHKLS NQNNSYGTRF EYNKESFS         10         20         30         40         50         60
MAVSWRSWLA NEGVKHLCLF IWLSMNVLLF WKTFLLYNQG PEYHYLHQML GLGLCLSRAS
        70         80         90        100        110        120
ASVLNLNCSL ILLPMCRTLL AYLRGSQKVP SRRTRRLLDK SRTFHITCGV TICIFSGVHV
       130        140        150        160        170        180
AAHLVNALNF SVNYSEDFVE LNAARYRDED PRKLLFTTVP GLTGVCMVVV LFLMITASTY
       190        200        210        220        230        240
AIRVSNYDIF WYTHNLFFVF YMLLTLHVSG GLLKYQTNLD THPPGCISLN RTSSQNISLP
       250        260        270        280        290        300
EYFSEHFHEP FPEGFSKPAE FTQHKFVKIC MEEPRFQANF PQTWLWISGP LCLYCAERLY
       310        320        330        340        350        360
RYIRSNKPVT IISVMSHPSD VMEIRMVKEN FKARPGQYIT LHCPSVSALE NHPFTLTMCP
       370        380        390        400        410        420
TETKATFGVH LKIVGDWTER FRDLLLPPSS QDSEILPFIQ SRNYPKLYID GPFGSPFEES
       430        440        450        460        470        480
LNYEVSLCVA GGIGVTPFAS ILNTLLDDWK PYKLRRLYFI WVCRDIQSFR WFADLLCMLH
       490        500        510        520        530        540
NKFWQENRPD YVNIQLYLSQ TDGIQKIIGE KYHALNSRLF IGRPRWKLLF DEIAKYNRGK
       550        560        570
TVGVFCCGPN SLSKTLHKLS NQNNSYGTRF EYNKESFS         10         20         30         40         50         60
MAVSWRSWLA NEGVKHLCLF IWLSMNVLLF WKTFLLYNQG PEYHYLHQML GLGLCLSRAS
        70         80         90        100        110        120
ASVLNLNCSL ILLPMCRTLL AYLRGSQKVP SRRTRRLLDK SRTFHITCGV TICIFSGVHV
       130        140        150        160        170        180
AAHLVNALNF SVNYSEDFVE LNAARYRDED PRKLLFTTVP GLTGVCMVVV LFLMITASTY
       190        200        210        220        230        240
AIRVSNYDIF WYTHNLFFVF YMLLTLHVSG GLLKYQTNLD THPPGCISLN RTSSQNISLP
       250        260        270        280        290        300
EYFSEHFHEP FPEGFSKPAE FTQHKFVKIC MEEPRFQANF PQTWLWISGP LCLYCAERLY
       310        320        330        340        350        360
RYIRSNKPVT IISVMSHPSD VMEIRMVKEN FKARPGQYIT LHCPSVSALE NHPFTLTMCP
       370        380        390        400        410        420
TETKATFGVH LKIVGDWTER FRDLLLPPSS QDSEILPFIQ SRNYPKLYID GPFGSPFEES
       430        440        450        460        470        480
LNYEVSLCVA GGIGVTPFAS ILNTLLDDWK PYKLRRLYFI WVCRDIQSFR WFADLLCMLH
       490        500        510        520        530        540
NKFWQENRPD YVNIQLYLSQ TDGIQKIIGE KYHALNSRLF IGRPRWKLLF DEIAKYNRGK
       550        560        570
TVGVFCCGPN SLSKTLHKLS NQNNSYGTRF EYNKESFS         10         20         30         40         50         60
MAVSWRSWLA NEGVKHLCLF IWLSMNVLLF WKTFLLYNQG PEYHYLHQML GLGLCLSRAS
        70         80         90        100        110        120
ASVLNLNCSL ILLPMCRTLL AYLRGSQKVP SRRTRRLLDK SRTFHITCGV TICIFSGVHV
       130        140        150        160        170        180
AAHLVNALNF SVNYSEDFVE LNAARYRDED PRKLLFTTVP GLTGVCMVVV LFLMITASTY
       190        200        210        220        230        240
AIRVSNYDIF WYTHNLFFVF YMLLTLHVSG GLLKYQTNLD THPPGCISLN RTSSQNISLP
       250        260        270        280        290        300
EYFSEHFHEP FPEGFSKPAE FTQHKFVKIC MEEPRFQANF PQTWLWISGP LCLYCAERLY
       310        320        330        340        350        360
RYIRSNKPVT IISVMSHPSD VMEIRMVKEN FKARPGQYIT LHCPSVSALE NHPFTLTMCP
       370        380        390        400        410        420
TETKATFGVH LKIVGDWTER FRDLLLPPSS QDSEILPFIQ SRNYPKLYID GPFGSPFEES
       430        440        450        460        470        480
LNYEVSLCVA GGIGVTPFAS ILNTLLDDWK PYKLRRLYFI WVCRDIQSFR WFADLLCMLH
       490        500        510        520        530        540
NKFWQENRPD YVNIQLYLSQ TDGIQKIIGE KYHALNSRLF IGRPRWKLLF DEIAKYNRGK
       550        560        570
TVGVFCCGPN SLSKTLHKLS NQNNSYGTRF EYNKESFS         10         20         30         40         50         60
MAVSWRSWLA NEGVKHLCLF IWLSMNVLLF WKTFLLYNQG PEYHYLHQML GLGLCLSRAS
        70         80         90        100        110        120
ASVLNLNCSL ILLPMCRTLL AYLRGSQKVP SRRTRRLLDK SRTFHITCGV TICIFSGVHV
       130        140        150        160        170        180
AAHLVNALNF SVNYSEDFVE LNAARYRDED PRKLLFTTVP GLTGVCMVVV LFLMITASTY
       190        200        210        220        230        240
AIRVSNYDIF WYTHNLFFVF YMLLTLHVSG GLLKYQTNLD THPPGCISLN RTSSQNISLP
       250        260        270        280        290        300
EYFSEHFHEP FPEGFSKPAE FTQHKFVKIC MEEPRFQANF PQTWLWISGP LCLYCAERLY
       310        320        330        340        350        360
RYIRSNKPVT IISVMSHPSD VMEIRMVKEN FKARPGQYIT LHCPSVSALE NHPFTLTMCP
       370        380        390        400        410        420
TETKATFGVH LKIVGDWTER FRDLLLPPSS QDSEILPFIQ SRNYPKLYID GPFGSPFEES
       430        440        450        460        470        480
LNYEVSLCVA GGIGVTPFAS ILNTLLDDWK PYKLRRLYFI WVCRDIQSFR WFADLLCMLH
       490        500        510        520        530        540
NKFWQENRPD YVNIQLYLSQ TDGIQKIIGE KYHALNSRLF IGRPRWKLLF DEIAKYNRGK
       550        560        570
TVGVFCCGPN SLSKTLHKLS NQNNSYGTRF EYNKESFS

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9NPH5-1-unknown	MAVSWR...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9NPH5-1-unknown	MAVSWR...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt83074
Q9NPH5-1-unknown	MAVSWR...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt83075
Q9NPH5-1-unknown	MAVSWR...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt83076
Q9NPH5-1-unknown	MAVSWR...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt83077
Q9NPH5-1-unknown	MAVSWR...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt83078
Q9NPH5-25-unknown	MNVLLF...	25	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt83079
Q9NPH5-25-unknown	MNVLLF...	25	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt83080
Q9NPH5-25-unknown	MNVLLF...	25	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000344747
Q9NPH5-25-unknown	MNVLLF...	25	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000434924
Q9NPH5-25-unknown	MNVLLF...	25	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000433797
Q9NPH5-25-unknown	MNVLLF...	25	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000412446
Q9NPH5-25-unknown	MNVLLF...	25	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000440172
Q9NPH5-25-unknown	MNVLLF...	25	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000439373
Q9NPH5-25-unknown	MNVLLF...	25	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt103552
Q9NPH5-25-unknown	MNVLLF...	25	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt103553
Q9NPH5-25-unknown	MNVLLF...	25	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt103554
Q9NPH5-25-unknown	MNVLLF...	25	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt103555
Q9NPH5-25-unknown	MNVLLF...	25	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt103556
Q9NPH5-75-unknown	MCRTLL...	75	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt83073
Q9NPH5-75-unknown	MCRTLL...	75	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt103207
Q9NPH5-75-unknown	MCRTLL...	75	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt103208
Q9NPH5-75-unknown	MCRTLL...	75	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt103209
Q9NPH5-75-unknown	MCRTLL...	75	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt103210
Q9NPH5-167-unknown	MVVVLF...	167	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000436093
Q9NPH5-167-unknown	MVVVLF...	167	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt197792
Q9NPH5-167-unknown	MVVVLF...	167	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt197788
Q9NPH5-167-unknown	MVVVLF...	167	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt197789
Q9NPH5-167-unknown	MVVVLF...	167	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt197790
Q9NPH5-167-unknown	MVVVLF...	167	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt197791

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KESFS	578	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KESFS	578	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78692
...KESFS	578	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78693
...KESFS	578	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78691
...KESFS	578	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78698
...KESFS	578	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78695
...KESFS	578	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78697

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)