TopFIND 4.0

Q9NR20: Dual specificity tyrosine-phosphorylation-regulated kinase 4

General Information

Protein names
- Dual specificity tyrosine-phosphorylation-regulated kinase 4
- 2.7.12.1
Gene names DYRK4
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q9NR20

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MPASELKASE IPFHPSIKTQ DPKAEEKSPK KQKVTLTAAE ALKLFKNQLS PYEQSEILGY 
        70         80         90        100        110        120 
AELWFLGLEA KKLDTAPEKF SKTSFDDEHG FYLKVLHDHI AYRYEVLETI GKGSFGQVAK 
       130        140        150        160        170        180 
CLDHKNNELV ALKIIRNKKR FHQQALMELK ILEALRKKDK DNTYNVVHMK DFFYFRNHFC 
       190        200        210        220        230        240 
ITFELLGINL YELMKNNNFQ GFSLSIVRRF TLSVLKCLQM LSVEKIIHCD LKPENIVLYQ 
       250        260        270        280        290        300 
KGQASVKVID FGSSCYEHQK VYTYIQSRFY RSPEVILGHP YDVAIDMWSL GCITAELYTG 
       310        320        330        340        350        360 
YPLFPGENEV EQLACIMEVL GLPPAGFIQT ASRRQTFFDS KGFPKNITNN RGKKRYPDSK 
       370        380        390        400        410        420 
DLTMVLKTYD TSFLDFLRRC LVWEPSLRMT PDQALKHAWI HQSRNLKPQP RPQTLRKSNS 
       430        440        450        460        470        480 
FFPSETRKDK VQGCHHSSRK ADEITKETTE KTKDSPTKHV QHSGDQQDCL QHGADTVQLP 
       490        500        510        520    
QLVDAPKKSE AAVGAEVSMT SPGQSKNFSL KNTNVLPPIV 

Isoforms

- Isoform 2 of Dual specificity tyrosine-phosphorylation-regulated kinase 4 - Isoform 3 of Dual specificity tyrosine-phosphorylation-regulated kinase 4 - Isoform 4 of Dual specificity tyrosine-phosphorylation-regulated kinase 4 - Isoform 5 of Dual specificity tyrosine-phosphorylation-regulated kinase 4

Sequence View

        10         20         30         40         50         60 
MPASELKASE IPFHPSIKTQ DPKAEEKSPK KQKVTLTAAE ALKLFKNQLS PYEQSEILGY 
        70         80         90        100        110        120 
AELWFLGLEA KKLDTAPEKF SKTSFDDEHG FYLKVLHDHI AYRYEVLETI GKGSFGQVAK 
       130        140        150        160        170        180 
CLDHKNNELV ALKIIRNKKR FHQQALMELK ILEALRKKDK DNTYNVVHMK DFFYFRNHFC 
       190        200        210        220        230        240 
ITFELLGINL YELMKNNNFQ GFSLSIVRRF TLSVLKCLQM LSVEKIIHCD LKPENIVLYQ 
       250        260        270        280        290        300 
KGQASVKVID FGSSCYEHQK VYTYIQSRFY RSPEVILGHP YDVAIDMWSL GCITAELYTG 
       310        320        330        340        350        360 
YPLFPGENEV EQLACIMEVL GLPPAGFIQT ASRRQTFFDS KGFPKNITNN RGKKRYPDSK 
       370        380        390        400        410        420 
DLTMVLKTYD TSFLDFLRRC LVWEPSLRMT PDQALKHAWI HQSRNLKPQP RPQTLRKSNS 
       430        440        450        460        470        480 
FFPSETRKDK VQGCHHSSRK ADEITKETTE KTKDSPTKHV QHSGDQQDCL QHGADTVQLP 
       490        500        510        520    
QLVDAPKKSE AAVGAEVSMT SPGQSKNFSL KNTNVLPPIV          10         20         30         40         50         60 
MPASELKASE IPFHPSIKTQ DPKAEEKSPK KQKVTLTAAE ALKLFKNQLS PYEQSEILGY 
        70         80         90        100        110        120 
AELWFLGLEA KKLDTAPEKF SKTSFDDEHG FYLKVLHDHI AYRYEVLETI GKGSFGQVAK 
       130        140        150        160        170        180 
CLDHKNNELV ALKIIRNKKR FHQQALMELK ILEALRKKDK DNTYNVVHMK DFFYFRNHFC 
       190        200        210        220        230        240 
ITFELLGINL YELMKNNNFQ GFSLSIVRRF TLSVLKCLQM LSVEKIIHCD LKPENIVLYQ 
       250        260        270        280        290        300 
KGQASVKVID FGSSCYEHQK VYTYIQSRFY RSPEVILGHP YDVAIDMWSL GCITAELYTG 
       310        320        330        340        350        360 
YPLFPGENEV EQLACIMEVL GLPPAGFIQT ASRRQTFFDS KGFPKNITNN RGKKRYPDSK 
       370        380        390        400        410        420 
DLTMVLKTYD TSFLDFLRRC LVWEPSLRMT PDQALKHAWI HQSRNLKPQP RPQTLRKSNS 
       430        440        450        460        470        480 
FFPSETRKDK VQGCHHSSRK ADEITKETTE KTKDSPTKHV QHSGDQQDCL QHGADTVQLP 
       490        500        510        520    
QLVDAPKKSE AAVGAEVSMT SPGQSKNFSL KNTNVLPPIV          10         20         30         40         50         60 
MPASELKASE IPFHPSIKTQ DPKAEEKSPK KQKVTLTAAE ALKLFKNQLS PYEQSEILGY 
        70         80         90        100        110        120 
AELWFLGLEA KKLDTAPEKF SKTSFDDEHG FYLKVLHDHI AYRYEVLETI GKGSFGQVAK 
       130        140        150        160        170        180 
CLDHKNNELV ALKIIRNKKR FHQQALMELK ILEALRKKDK DNTYNVVHMK DFFYFRNHFC 
       190        200        210        220        230        240 
ITFELLGINL YELMKNNNFQ GFSLSIVRRF TLSVLKCLQM LSVEKIIHCD LKPENIVLYQ 
       250        260        270        280        290        300 
KGQASVKVID FGSSCYEHQK VYTYIQSRFY RSPEVILGHP YDVAIDMWSL GCITAELYTG 
       310        320        330        340        350        360 
YPLFPGENEV EQLACIMEVL GLPPAGFIQT ASRRQTFFDS KGFPKNITNN RGKKRYPDSK 
       370        380        390        400        410        420 
DLTMVLKTYD TSFLDFLRRC LVWEPSLRMT PDQALKHAWI HQSRNLKPQP RPQTLRKSNS 
       430        440        450        460        470        480 
FFPSETRKDK VQGCHHSSRK ADEITKETTE KTKDSPTKHV QHSGDQQDCL QHGADTVQLP 
       490        500        510        520    
QLVDAPKKSE AAVGAEVSMT SPGQSKNFSL KNTNVLPPIV          10         20         30         40         50         60 
MPASELKASE IPFHPSIKTQ DPKAEEKSPK KQKVTLTAAE ALKLFKNQLS PYEQSEILGY 
        70         80         90        100        110        120 
AELWFLGLEA KKLDTAPEKF SKTSFDDEHG FYLKVLHDHI AYRYEVLETI GKGSFGQVAK 
       130        140        150        160        170        180 
CLDHKNNELV ALKIIRNKKR FHQQALMELK ILEALRKKDK DNTYNVVHMK DFFYFRNHFC 
       190        200        210        220        230        240 
ITFELLGINL YELMKNNNFQ GFSLSIVRRF TLSVLKCLQM LSVEKIIHCD LKPENIVLYQ 
       250        260        270        280        290        300 
KGQASVKVID FGSSCYEHQK VYTYIQSRFY RSPEVILGHP YDVAIDMWSL GCITAELYTG 
       310        320        330        340        350        360 
YPLFPGENEV EQLACIMEVL GLPPAGFIQT ASRRQTFFDS KGFPKNITNN RGKKRYPDSK 
       370        380        390        400        410        420 
DLTMVLKTYD TSFLDFLRRC LVWEPSLRMT PDQALKHAWI HQSRNLKPQP RPQTLRKSNS 
       430        440        450        460        470        480 
FFPSETRKDK VQGCHHSSRK ADEITKETTE KTKDSPTKHV QHSGDQQDCL QHGADTVQLP 
       490        500        510        520    
QLVDAPKKSE AAVGAEVSMT SPGQSKNFSL KNTNVLPPIV 



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Evidence Codes:


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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q9NR20-1-unknown MPASEL... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q9NR20-1-unknown MPASEL... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt73449

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...LPPIV 520 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...LPPIV 520 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt69067

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)