TopFIND 4.0

Q9NRR6: Phosphatidylinositol polyphosphate 5-phosphatase type IV {ECO:0000305}

General Information

Protein names
- Phosphatidylinositol polyphosphate 5-phosphatase type IV {ECO:0000305}
- 72 kDa inositol polyphosphate 5-phosphatase
- Inositol polyphosphate-5-phosphatase E {ECO:0000303|PubMed:19668216}
- Phosphatidylinositol 4,5-bisphosphate 5-phosphatase {ECO:0000305}
- 3.1.3.36 {ECO:0000269|PubMed:10764818, ECO:0000269|PubMed:19668216}
- Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase {ECO:0000305}
- 3.1.3.86 {ECO:0000269|PubMed:10764818}
Gene names INPP5E
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q9NRR6

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MPSKAENLRP SEPAPQPPEG RTLQGQLPGA PPAQRAGSPP DAPGSESPAL ACSTPATPSG 
        70         80         90        100        110        120 
EDPPARAAPI APRPPARPRL ERALSLDDKG WRRRRFRGSQ EDLEARNGTS PSRGSVQSEG 
       130        140        150        160        170        180 
PGAPAHSCSP PCLSTSLQEI PKSRGVLSSE RGSPSSGGNP LSGVASSSPN LPHRDAAVAG 
       190        200        210        220        230        240 
SSPRLPSLLP PRPPPALSLD IASDSLRTAN KVDSDLADYK LRAQPLLVRA HSSLGPGRPR 
       250        260        270        280        290        300 
SPLACDDCSL RSAKSSFSLL APIRSKDVRS RSYLEGSLLA SGALLGADEL ARYFPDRNVA 
       310        320        330        340        350        360 
LFVATWNMQG QKELPPSLDE FLLPAEADYA QDLYVIGVQE GCSDRREWET RLQETLGPHY 
       370        380        390        400        410        420 
VLLSSAAHGV LYMSLFIRRD LIWFCSEVEC STVTTRIVSQ IKTKGALGIS FTFFGTSFLF 
       430        440        450        460        470        480 
ITSHFTSGDG KVAERLLDYT RTVQALVLPR NVPDTNPYRS SAADVTTRFD EVFWFGDFNF 
       490        500        510        520        530        540 
RLSGGRTVVD ALLCQGLVVD VPALLQHDQL IREMRKGSIF KGFQEPDIHF LPSYKFDIGK 
       550        560        570        580        590        600 
DTYDSTSKQR TPSYTDRVLY RSRHKGDICP VSYSSCPGIK TSDHRPVYGL FRVKVRPGRD 
       610        620        630        640    
NIPLAAGKFD RELYLLGIKR RISKEIQRQQ ALQSQNSSTI CSVS

Isoforms

- Isoform 2 of 72 kDa inositol polyphosphate 5-phosphatase - Isoform 2 of Phosphatidylinositol polyphosphate 5-phosphatase type IV

Sequence View

        10         20         30         40         50         60 
MPSKAENLRP SEPAPQPPEG RTLQGQLPGA PPAQRAGSPP DAPGSESPAL ACSTPATPSG 
        70         80         90        100        110        120 
EDPPARAAPI APRPPARPRL ERALSLDDKG WRRRRFRGSQ EDLEARNGTS PSRGSVQSEG 
       130        140        150        160        170        180 
PGAPAHSCSP PCLSTSLQEI PKSRGVLSSE RGSPSSGGNP LSGVASSSPN LPHRDAAVAG 
       190        200        210        220        230        240 
SSPRLPSLLP PRPPPALSLD IASDSLRTAN KVDSDLADYK LRAQPLLVRA HSSLGPGRPR 
       250        260        270        280        290        300 
SPLACDDCSL RSAKSSFSLL APIRSKDVRS RSYLEGSLLA SGALLGADEL ARYFPDRNVA 
       310        320        330        340        350        360 
LFVATWNMQG QKELPPSLDE FLLPAEADYA QDLYVIGVQE GCSDRREWET RLQETLGPHY 
       370        380        390        400        410        420 
VLLSSAAHGV LYMSLFIRRD LIWFCSEVEC STVTTRIVSQ IKTKGALGIS FTFFGTSFLF 
       430        440        450        460        470        480 
ITSHFTSGDG KVAERLLDYT RTVQALVLPR NVPDTNPYRS SAADVTTRFD EVFWFGDFNF 
       490        500        510        520        530        540 
RLSGGRTVVD ALLCQGLVVD VPALLQHDQL IREMRKGSIF KGFQEPDIHF LPSYKFDIGK 
       550        560        570        580        590        600 
DTYDSTSKQR TPSYTDRVLY RSRHKGDICP VSYSSCPGIK TSDHRPVYGL FRVKVRPGRD 
       610        620        630        640    
NIPLAAGKFD RELYLLGIKR RISKEIQRQQ ALQSQNSSTI CSVS         10         20         30         40         50         60 
MPSKAENLRP SEPAPQPPEG RTLQGQLPGA PPAQRAGSPP DAPGSESPAL ACSTPATPSG 
        70         80         90        100        110        120 
EDPPARAAPI APRPPARPRL ERALSLDDKG WRRRRFRGSQ EDLEARNGTS PSRGSVQSEG 
       130        140        150        160        170        180 
PGAPAHSCSP PCLSTSLQEI PKSRGVLSSE RGSPSSGGNP LSGVASSSPN LPHRDAAVAG 
       190        200        210        220        230        240 
SSPRLPSLLP PRPPPALSLD IASDSLRTAN KVDSDLADYK LRAQPLLVRA HSSLGPGRPR 
       250        260        270        280        290        300 
SPLACDDCSL RSAKSSFSLL APIRSKDVRS RSYLEGSLLA SGALLGADEL ARYFPDRNVA 
       310        320        330        340        350        360 
LFVATWNMQG QKELPPSLDE FLLPAEADYA QDLYVIGVQE GCSDRREWET RLQETLGPHY 
       370        380        390        400        410        420 
VLLSSAAHGV LYMSLFIRRD LIWFCSEVEC STVTTRIVSQ IKTKGALGIS FTFFGTSFLF 
       430        440        450        460        470        480 
ITSHFTSGDG KVAERLLDYT RTVQALVLPR NVPDTNPYRS SAADVTTRFD EVFWFGDFNF 
       490        500        510        520        530        540 
RLSGGRTVVD ALLCQGLVVD VPALLQHDQL IREMRKGSIF KGFQEPDIHF LPSYKFDIGK 
       550        560        570        580        590        600 
DTYDSTSKQR TPSYTDRVLY RSRHKGDICP VSYSSCPGIK TSDHRPVYGL FRVKVRPGRD 
       610        620        630        640    
NIPLAAGKFD RELYLLGIKR RISKEIQRQQ ALQSQNSSTI CSVS



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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q9NRR6-1-unknown MPSKAE... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q9NRR6-1-unknown MPSKAE... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt77926

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...ICSVS 644 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...ICSVS 644 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt73544

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)