TopFIND 4.0

Q9NST1: 1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 {ECO:0000305|PubMed:22560221}

General Information

Protein names
- 1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 {ECO:0000305|PubMed:22560221}
- 2.3.1.51 {ECO:0000269|PubMed:22560221}
- Acylglycerol transacylase {ECO:0000303|PubMed:15364929}
- Adiponutrin {ECO:0000303|PubMed:22560221}
- ADPN {ECO:0000303|PubMed:22560221}
- Calcium-independent phospholipase A2-epsilon {ECO:0000303|PubMed:15364929}
- iPLA2-epsilon {ECO:0000303|PubMed:15364929}
- Lysophosphatidic acid acyltransferase {ECO:0000303|PubMed:22560221}
- Patatin-like phospholipase domain-containing protein 3 {ECO:0000303|PubMed:19224197}
- 3.1.1.3 {ECO:0000269|PubMed:15364929, ECO:0000269|PubMed:20034933, ECO:0000269|PubMed:22560221}
Gene names PNPLA3
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q9NST1

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MYDAERGWSL SFAGCGFLGF YHVGATRCLS EHAPHLLRDA RMLFGASAGA LHCVGVLSGI 
        70         80         90        100        110        120 
PLEQTLQVLS DLVRKARSRN IGIFHPSFNL SKFLRQGLCK CLPANVHQLI SGKIGISLTR 
       130        140        150        160        170        180 
VSDGENVLVS DFRSKDEVVD ALVCSCFIPF YSGLIPPSFR GVRYVDGGVS DNVPFIDAKT 
       190        200        210        220        230        240 
TITVSPFYGE YDICPKVKST NFLHVDITKL SLRLCTGNLY LLSRAFVPPD LKVLGEICLR 
       250        260        270        280        290        300 
GYLDAFRFLE EKGICNRPQP GLKSSSEGMD PEVAMPSWAN MSLDSSPESA ALAVRLEGDE 
       310        320        330        340        350        360 
LLDHLRLSIL PWDESILDTL SPRLATALSE EMKDKGGYMS KICNLLPIRI MSYVMLPCTL 
       370        380        390        400        410        420 
PVESAIAIVQ RLVTWLPDMP DDVLWLQWVT SQVFTRVLMC LLPASRSQMP VSSQQASPCT 
       430        440        450        460        470        480 
PEQDWPCWTP CSPKGCPAET KAEATPRSIL RSSLNFFLGN KVPAGAEGLS TFPSFSLEKS 
   
L

Isoforms

- Isoform 2 of Patatin-like phospholipase domain-containing protein 3 - Isoform 2 of 1-acylglycerol-3-phosphate O-acyltransferase PNPLA3

Sequence View

        10         20         30         40         50         60 
MYDAERGWSL SFAGCGFLGF YHVGATRCLS EHAPHLLRDA RMLFGASAGA LHCVGVLSGI 
        70         80         90        100        110        120 
PLEQTLQVLS DLVRKARSRN IGIFHPSFNL SKFLRQGLCK CLPANVHQLI SGKIGISLTR 
       130        140        150        160        170        180 
VSDGENVLVS DFRSKDEVVD ALVCSCFIPF YSGLIPPSFR GVRYVDGGVS DNVPFIDAKT 
       190        200        210        220        230        240 
TITVSPFYGE YDICPKVKST NFLHVDITKL SLRLCTGNLY LLSRAFVPPD LKVLGEICLR 
       250        260        270        280        290        300 
GYLDAFRFLE EKGICNRPQP GLKSSSEGMD PEVAMPSWAN MSLDSSPESA ALAVRLEGDE 
       310        320        330        340        350        360 
LLDHLRLSIL PWDESILDTL SPRLATALSE EMKDKGGYMS KICNLLPIRI MSYVMLPCTL 
       370        380        390        400        410        420 
PVESAIAIVQ RLVTWLPDMP DDVLWLQWVT SQVFTRVLMC LLPASRSQMP VSSQQASPCT 
       430        440        450        460        470        480 
PEQDWPCWTP CSPKGCPAET KAEATPRSIL RSSLNFFLGN KVPAGAEGLS TFPSFSLEKS 
   
L         10         20         30         40         50         60 
MYDAERGWSL SFAGCGFLGF YHVGATRCLS EHAPHLLRDA RMLFGASAGA LHCVGVLSGI 
        70         80         90        100        110        120 
PLEQTLQVLS DLVRKARSRN IGIFHPSFNL SKFLRQGLCK CLPANVHQLI SGKIGISLTR 
       130        140        150        160        170        180 
VSDGENVLVS DFRSKDEVVD ALVCSCFIPF YSGLIPPSFR GVRYVDGGVS DNVPFIDAKT 
       190        200        210        220        230        240 
TITVSPFYGE YDICPKVKST NFLHVDITKL SLRLCTGNLY LLSRAFVPPD LKVLGEICLR 
       250        260        270        280        290        300 
GYLDAFRFLE EKGICNRPQP GLKSSSEGMD PEVAMPSWAN MSLDSSPESA ALAVRLEGDE 
       310        320        330        340        350        360 
LLDHLRLSIL PWDESILDTL SPRLATALSE EMKDKGGYMS KICNLLPIRI MSYVMLPCTL 
       370        380        390        400        410        420 
PVESAIAIVQ RLVTWLPDMP DDVLWLQWVT SQVFTRVLMC LLPASRSQMP VSSQQASPCT 
       430        440        450        460        470        480 
PEQDWPCWTP CSPKGCPAET KAEATPRSIL RSSLNFFLGN KVPAGAEGLS TFPSFSLEKS 
   
L



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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q9NST1-1-unknown MYDAER... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q9NST1-1-unknown MYDAER... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt85590

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...LEKSL 481 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...LEKSL 481 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt81208

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)