Q9NUW8: Tyrosyl-DNA phosphodiesterase 1

General Information

Protein names	- Tyrosyl-DNA phosphodiesterase 1 - Tyr-DNA phosphodiesterase 1 - 3.1.4.- {ECO:0000269\|PubMed:15111055, ECO:0000269\|PubMed:16141202, ECO:0000269\|PubMed:22822062}
Gene names	TDP1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9NUW8

3 N-termini

7 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSQEGDYGRW TISSSDESEE EKPKPDKPST SSLLCARQGA ANEPRYTCSE AQKAAHKRKI
        70         80         90        100        110        120
SPVKFSNTDS VLPPKRQKSG SQEDLGWCLS SSDDELQPEM PQKQAEKVVI KKEKDISAPN
       130        140        150        160        170        180
DGTAQRTENH GAPACHRLKE EEDEYETSGE GQDIWDMLDK GNPFQFYLTR VSGVKPKYNS
       190        200        210        220        230        240
GALHIKDILS PLFGTLVSSA QFNYCFDVDW LVKQYPPEFR KKPILLVHGD KREAKAHLHA
       250        260        270        280        290        300
QAKPYENISL CQAKLDIAFG THHTKMMLLL YEEGLRVVIH TSNLIHADWH QKTQGIWLSP
       310        320        330        340        350        360
LYPRIADGTH KSGESPTHFK ADLISYLMAY NAPSLKEWID VIHKHDLSET NVYLIGSTPG
       370        380        390        400        410        420
RFQGSQKDNW GHFRLKKLLK DHASSMPNAE SWPVVGQFSS VGSLGADESK WLCSEFKESM
       430        440        450        460        470        480
LTLGKESKTP GKSSVPLYLI YPSVENVRTS LEGYPAGGSL PYSIQTAEKQ NWLHSYFHKW
       490        500        510        520        530        540
SAETSGRSNA MPHIKTYMRP SPDFSKIAWF LVTSANLSKA AWGALEKNGT QLMIRSYELG
       550        560        570        580        590        600
VLFLPSAFGL DSFKVKQKFF AGSQEPMATF PVPYDLPPEL YGSKDRPWIW NIPYVKAPDT

HGNMWVPS

Isoforms

- Isoform 2 of Tyrosyl-DNA phosphodiesterase 1

Sequence View

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Protein Neighborhood

Domains & Features

3 N-termini - 7 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9NUW8-1-unknown	MSQEGD...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9NUW8-2-acetylation	SQEGDY...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9NUW8-2-acetylation	SQEGDY...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9NUW8-100-unknown	MPQKQA...	100		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000450708

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EDEYET	146	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000451358
...DEYETS	147	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000452333
...TSGEGQ	151	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000452279
...MLDKGN	161	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000452183
...LRVVIH	279	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000450872
...ESPTHF	318	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000450708
...MWVPS	608	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)