Q9NVH6: Trimethyllysine dioxygenase, mitochondrial

General Information

Protein names	- Trimethyllysine dioxygenase, mitochondrial - 1.14.11.8 {ECO:0000269\|PubMed:27965989, ECO:0000269\|PubMed:28045275} - Epsilon-trimethyllysine 2-oxoglutarate dioxygenase - Epsilon-trimethyllysine hydroxylase - TML hydroxylase - TML-alpha-ketoglutarate dioxygenase - TML dioxygenase - TMLD
Gene names	TMLHE
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9NVH6

3 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Trimethyllysine dioxygenase, mitochondrial - Isoform 3 of Trimethyllysine dioxygenase, mitochondrial - Isoform 4 of Trimethyllysine dioxygenase, mitochondrial - Isoform 5 of Trimethyllysine dioxygenase, mitochondrial - Isoform 6 of Trimethyllysine dioxygenase, mitochondrial - Isoform 7 of Trimethyllysine dioxygenase, mitochondrial - Isoform 8 of Trimethyllysine dioxygenase, mitochondrial

Sequence View

        10         20         30         40         50         60
MWYHRLSHLH SRLQDLLKGG VIYPALPQPN FKSLLPLAVH WHHTASKSLT CAWQQHEDHF
        70         80         90        100        110        120
ELKYANTVMR FDYVWLRDHC RSASCYNSKT HQRSLDTASV DLCIKPKTIR LDETTLFFTW
       130        140        150        160        170        180
PDGHVTKYDL NWLVKNSYEG QKQKVIQPRI LWNAEIYQQA QVPSVDCQSF LETNEGLKKF
       190        200        210        220        230        240
LQNFLLYGIA FVENVPPTQE HTEKLAERIS LIRETIYGRM WYFTSDFSRG DTAYTKLALD
       250        260        270        280        290        300
RHTDTTYFQE PCGIQVFHCL KHEGTGGRTL LVDGFYAAEQ VLQKAPEEFE LLSKVPLKHE
       310        320        330        340        350        360
YIEDVGECHN HMIGIGPVLN IYPWNKELYL IRYNNYDRAV INTVPYDVVH RWYTAHRTLT
       370        380        390        400        410        420
IELRRPENEF WVKLKPGRVL FIDNWRVLHG RECFTGYRQL CGCYLTRDDV LNTARLLGLQ

A         10         20         30         40         50         60
MWYHRLSHLH SRLQDLLKGG VIYPALPQPN FKSLLPLAVH WHHTASKSLT CAWQQHEDHF
        70         80         90        100        110        120
ELKYANTVMR FDYVWLRDHC RSASCYNSKT HQRSLDTASV DLCIKPKTIR LDETTLFFTW
       130        140        150        160        170        180
PDGHVTKYDL NWLVKNSYEG QKQKVIQPRI LWNAEIYQQA QVPSVDCQSF LETNEGLKKF
       190        200        210        220        230        240
LQNFLLYGIA FVENVPPTQE HTEKLAERIS LIRETIYGRM WYFTSDFSRG DTAYTKLALD
       250        260        270        280        290        300
RHTDTTYFQE PCGIQVFHCL KHEGTGGRTL LVDGFYAAEQ VLQKAPEEFE LLSKVPLKHE
       310        320        330        340        350        360
YIEDVGECHN HMIGIGPVLN IYPWNKELYL IRYNNYDRAV INTVPYDVVH RWYTAHRTLT
       370        380        390        400        410        420
IELRRPENEF WVKLKPGRVL FIDNWRVLHG RECFTGYRQL CGCYLTRDDV LNTARLLGLQ

A         10         20         30         40         50         60
MWYHRLSHLH SRLQDLLKGG VIYPALPQPN FKSLLPLAVH WHHTASKSLT CAWQQHEDHF
        70         80         90        100        110        120
ELKYANTVMR FDYVWLRDHC RSASCYNSKT HQRSLDTASV DLCIKPKTIR LDETTLFFTW
       130        140        150        160        170        180
PDGHVTKYDL NWLVKNSYEG QKQKVIQPRI LWNAEIYQQA QVPSVDCQSF LETNEGLKKF
       190        200        210        220        230        240
LQNFLLYGIA FVENVPPTQE HTEKLAERIS LIRETIYGRM WYFTSDFSRG DTAYTKLALD
       250        260        270        280        290        300
RHTDTTYFQE PCGIQVFHCL KHEGTGGRTL LVDGFYAAEQ VLQKAPEEFE LLSKVPLKHE
       310        320        330        340        350        360
YIEDVGECHN HMIGIGPVLN IYPWNKELYL IRYNNYDRAV INTVPYDVVH RWYTAHRTLT
       370        380        390        400        410        420
IELRRPENEF WVKLKPGRVL FIDNWRVLHG RECFTGYRQL CGCYLTRDDV LNTARLLGLQ

A         10         20         30         40         50         60
MWYHRLSHLH SRLQDLLKGG VIYPALPQPN FKSLLPLAVH WHHTASKSLT CAWQQHEDHF
        70         80         90        100        110        120
ELKYANTVMR FDYVWLRDHC RSASCYNSKT HQRSLDTASV DLCIKPKTIR LDETTLFFTW
       130        140        150        160        170        180
PDGHVTKYDL NWLVKNSYEG QKQKVIQPRI LWNAEIYQQA QVPSVDCQSF LETNEGLKKF
       190        200        210        220        230        240
LQNFLLYGIA FVENVPPTQE HTEKLAERIS LIRETIYGRM WYFTSDFSRG DTAYTKLALD
       250        260        270        280        290        300
RHTDTTYFQE PCGIQVFHCL KHEGTGGRTL LVDGFYAAEQ VLQKAPEEFE LLSKVPLKHE
       310        320        330        340        350        360
YIEDVGECHN HMIGIGPVLN IYPWNKELYL IRYNNYDRAV INTVPYDVVH RWYTAHRTLT
       370        380        390        400        410        420
IELRRPENEF WVKLKPGRVL FIDNWRVLHG RECFTGYRQL CGCYLTRDDV LNTARLLGLQ

A         10         20         30         40         50         60
MWYHRLSHLH SRLQDLLKGG VIYPALPQPN FKSLLPLAVH WHHTASKSLT CAWQQHEDHF
        70         80         90        100        110        120
ELKYANTVMR FDYVWLRDHC RSASCYNSKT HQRSLDTASV DLCIKPKTIR LDETTLFFTW
       130        140        150        160        170        180
PDGHVTKYDL NWLVKNSYEG QKQKVIQPRI LWNAEIYQQA QVPSVDCQSF LETNEGLKKF
       190        200        210        220        230        240
LQNFLLYGIA FVENVPPTQE HTEKLAERIS LIRETIYGRM WYFTSDFSRG DTAYTKLALD
       250        260        270        280        290        300
RHTDTTYFQE PCGIQVFHCL KHEGTGGRTL LVDGFYAAEQ VLQKAPEEFE LLSKVPLKHE
       310        320        330        340        350        360
YIEDVGECHN HMIGIGPVLN IYPWNKELYL IRYNNYDRAV INTVPYDVVH RWYTAHRTLT
       370        380        390        400        410        420
IELRRPENEF WVKLKPGRVL FIDNWRVLHG RECFTGYRQL CGCYLTRDDV LNTARLLGLQ

A         10         20         30         40         50         60
MWYHRLSHLH SRLQDLLKGG VIYPALPQPN FKSLLPLAVH WHHTASKSLT CAWQQHEDHF
        70         80         90        100        110        120
ELKYANTVMR FDYVWLRDHC RSASCYNSKT HQRSLDTASV DLCIKPKTIR LDETTLFFTW
       130        140        150        160        170        180
PDGHVTKYDL NWLVKNSYEG QKQKVIQPRI LWNAEIYQQA QVPSVDCQSF LETNEGLKKF
       190        200        210        220        230        240
LQNFLLYGIA FVENVPPTQE HTEKLAERIS LIRETIYGRM WYFTSDFSRG DTAYTKLALD
       250        260        270        280        290        300
RHTDTTYFQE PCGIQVFHCL KHEGTGGRTL LVDGFYAAEQ VLQKAPEEFE LLSKVPLKHE
       310        320        330        340        350        360
YIEDVGECHN HMIGIGPVLN IYPWNKELYL IRYNNYDRAV INTVPYDVVH RWYTAHRTLT
       370        380        390        400        410        420
IELRRPENEF WVKLKPGRVL FIDNWRVLHG RECFTGYRQL CGCYLTRDDV LNTARLLGLQ

A         10         20         30         40         50         60
MWYHRLSHLH SRLQDLLKGG VIYPALPQPN FKSLLPLAVH WHHTASKSLT CAWQQHEDHF
        70         80         90        100        110        120
ELKYANTVMR FDYVWLRDHC RSASCYNSKT HQRSLDTASV DLCIKPKTIR LDETTLFFTW
       130        140        150        160        170        180
PDGHVTKYDL NWLVKNSYEG QKQKVIQPRI LWNAEIYQQA QVPSVDCQSF LETNEGLKKF
       190        200        210        220        230        240
LQNFLLYGIA FVENVPPTQE HTEKLAERIS LIRETIYGRM WYFTSDFSRG DTAYTKLALD
       250        260        270        280        290        300
RHTDTTYFQE PCGIQVFHCL KHEGTGGRTL LVDGFYAAEQ VLQKAPEEFE LLSKVPLKHE
       310        320        330        340        350        360
YIEDVGECHN HMIGIGPVLN IYPWNKELYL IRYNNYDRAV INTVPYDVVH RWYTAHRTLT
       370        380        390        400        410        420
IELRRPENEF WVKLKPGRVL FIDNWRVLHG RECFTGYRQL CGCYLTRDDV LNTARLLGLQ

A

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(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9NVH6-1-unknown	MWYHRL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt92479
Q9NVH6-1-unknown	MWYHRL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt92480
Q9NVH6-1-unknown	MWYHRL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt92481
Q9NVH6-1-unknown	MWYHRL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt92482
Q9NVH6-1-unknown	MWYHRL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt92483
Q9NVH6-1-unknown	MWYHRL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt99394
Q9NVH6-16-unknown	LLKGGV...	16	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9NVH6-16-unknown	LLKGGV...	16	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111786
Q9NVH6-16-unknown	LLKGGV...	16	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111787
Q9NVH6-16-unknown	LLKGGV...	16	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111788
Q9NVH6-16-unknown	LLKGGV...	16	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111789
Q9NVH6-16-unknown	LLKGGV...	16	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111790
Q9NVH6-16-unknown	LLKGGV...	16	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111785
Q9NVH6-69-unknown	MRFDYV...	69	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt92484
Q9NVH6-69-unknown	MRFDYV...	69	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt99714
Q9NVH6-69-unknown	MRFDYV...	69	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt99715
Q9NVH6-69-unknown	MRFDYV...	69	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt99716
Q9NVH6-69-unknown	MRFDYV...	69	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt99717
Q9NVH6-69-unknown	MRFDYV...	69	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt99713

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LYLIRY	332	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt88098
...LYLIRY	332	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92428
...LYLIRY	332	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92429
...LYLIRY	332	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92430
...LYLIRY	332	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92431
...LYLIRY	332	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92432
...LYLIRY	332	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92427
...LGLQA	421	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LGLQA	421	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt88102
...LGLQA	421	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt88101
...LGLQA	421	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt88103

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)