Q9NWV8: BRISC and BRCA1-A complex member 1

General Information

Protein names	- BRISC and BRCA1-A complex member 1 - Mediator of RAP80 interactions and targeting subunit of 40 kDa {ECO:0000303\|PubMed:19261746} - New component of the BRCA1-A complex {ECO:0000303\|PubMed:19261749}
Gene names	BABAM1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9NWV8

4 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of BRISC and BRCA1-A complex member 1 - Isoform 3 of BRISC and BRCA1-A complex member 1

Sequence View

        10         20         30         40         50         60
MEVAEPSSPT EEEEEEEEHS AEPRPRTRSN PEGAEDRAVG AQASVGSRSE GEGEAASADD
        70         80         90        100        110        120
GSLNTSGAGP KSWQVPPPAP EVQIRTPRVN CPEKVIICLD LSEEMSLPKL ESFNGSKTNA
       130        140        150        160        170        180
LNVSQKMIEM FVRTKHKIDK SHEFALVVVN DDTAWLSGLT SDPRELCSCL YDLETASCST
       190        200        210        220        230        240
FNLEGLFSLI QQKTELPVTE NVQTIPPPYV VRTILVYSRP PCQPQFSLTE PMKKMFQCPY
       250        260        270        280        290        300
FFFDVVYIHN GTEEKEEEMS WKDMFAFMGS LDTKGTSYKY EVALAGPALE LHNCMAKLLA
       310        320
HPLQRPCQSH ASYSLLEEED EAIEVEATV         10         20         30         40         50         60
MEVAEPSSPT EEEEEEEEHS AEPRPRTRSN PEGAEDRAVG AQASVGSRSE GEGEAASADD
        70         80         90        100        110        120
GSLNTSGAGP KSWQVPPPAP EVQIRTPRVN CPEKVIICLD LSEEMSLPKL ESFNGSKTNA
       130        140        150        160        170        180
LNVSQKMIEM FVRTKHKIDK SHEFALVVVN DDTAWLSGLT SDPRELCSCL YDLETASCST
       190        200        210        220        230        240
FNLEGLFSLI QQKTELPVTE NVQTIPPPYV VRTILVYSRP PCQPQFSLTE PMKKMFQCPY
       250        260        270        280        290        300
FFFDVVYIHN GTEEKEEEMS WKDMFAFMGS LDTKGTSYKY EVALAGPALE LHNCMAKLLA
       310        320
HPLQRPCQSH ASYSLLEEED EAIEVEATV

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9NWV8-1-Acetylation	MEVAEP...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9NWV8-1-Acetylation	MEVAEP...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9NWV8-1-Acetylation	MEVAEP...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9NWV8-1-Acetylation	MEVAEP...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt103968
Q9NWV8-1-unknown	MEVAEP...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt68139
Q9NWV8-38-unknown	AVGAQA...	38		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178344
Q9NWV8-38-	AVGAQA...	38			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...EMSWKD	262	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt63756
	...VEATV	329	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)