Q9NXE4: Sphingomyelin phosphodiesterase 4 {ECO:0000305}

General Information

Protein names	- Sphingomyelin phosphodiesterase 4 {ECO:0000305} - 3.1.4.12 {ECO:0000269\|PubMed:16517606} - Neutral sphingomyelinase 3 {ECO:0000303\|PubMed:18505924} - nSMase-3 {ECO:0000303\|PubMed:18505924} - nSMase3 {ECO:0000303\|PubMed:18505924} - Neutral sphingomyelinase III
Gene names	SMPD4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9NXE4

6 N-termini

6 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Sphingomyelin phosphodiesterase 4 - Isoform 3 of Sphingomyelin phosphodiesterase 4 - Isoform 4 of Sphingomyelin phosphodiesterase 4 - Isoform 5 of Sphingomyelin phosphodiesterase 4 - Isoform 6 of Sphingomyelin phosphodiesterase 4 - Isoform 7 of Sphingomyelin phosphodiesterase 4 - Isoform 8 of Sphingomyelin phosphodiesterase 4 - Isoform 9 of Sphingomyelin phosphodiesterase 4 - Isoform 2 of Sphingomyelin phosphodiesterase 4 - Isoform 4 of Sphingomyelin phosphodiesterase 4 - Isoform 5 of Sphingomyelin phosphodiesterase 4 - Isoform 10 of Sphingomyelin phosphodiesterase 4

Sequence View

        10         20         30         40         50         60
MTTFGAVAEW RLPSLRRATL WIPQWFAKKA IFNSPLEAAM AFPHLQQPSF LLASLKADSI
        70         80         90        100        110        120
NKPFAQQCQD LVKVIEDFPA KELHTIFPWL VESIFGSLDG VLVGWNLRCL QGRVNPVEYS
       130        140        150        160        170        180
IVMEFLDPGG PMMKLVYKLQ AEDYKFDFPV SYLPGPVKAS IQECILPDSP LYHNKVQFTP
       190        200        210        220        230        240
TGGLGLNLAL NPFEYYIFFF ALSLITQKPL PVSLHVRTSD CAYFILVDRY LSWFLPTEGS
       250        260        270        280        290        300
VPPPLSSSPG GTSPSPPPRT PAIPFASYGL HHTSLLKRHI SHQTSVNADP ASHEIWRSET
       310        320        330        340        350        360
LLQVFVEMWL HHYSLEMYQK MQSPHAKLEV LHYRLSVSSA LYSPAQPSLQ ALHAYQESFT
       370        380        390        400        410        420
PTEEHVLVVR LLLKHLHAFA NSLKPEQASP SAHSHATSPL EEFKRAAVPR FVQQKLYLFL
       430        440        450        460        470        480
QHCFGHWPLD ASFRAVLEMW LSYLQPWRYA PDKQAPGSDS QPRCVSEKWA PFVQENLLMY
       490        500        510        520        530        540
TKLFVGFLNR ALRTDLVSPK HALMVFRVAK VFAQPNLAEM IQKGEQLFLE PELVIPHRQH
       550        560        570        580        590        600
RLFTAPTFTG SFLSPWPPAV TDASFKVKSH VYSLEGQDCK YTPMFGPEAR TLVLRLAQLI
       610        620        630        640        650        660
TQAKHTAKSI SDQCAESPAG HSFLSWLGFS SMDTNGSYTA NDLDEMGQDS VRKTDEYLEK
       670        680        690        700        710        720
ALEYLRQIFR LSEAQLRQFT LALGTTQDEN GKKQLPDCIV GEDGLILTPL GRYQIINGLR
       730        740        750        760        770        780
RFEIEYQGDP ELQPIRSYEI ASLVRTLFRL SSAINHRFAG QMAALCSRDD FLGSFCRYHL
       790        800        810        820        830        840
TEPGLASRHL LSPVGRRQVA GHTRGPRLSL RFLGSYRTLV SLLLAFFVAS LFCVGPLPCT
       850        860
LLLTLGYVLY ASAMTLLTER GKLHQP         10         20         30         40         50         60
MTTFGAVAEW RLPSLRRATL WIPQWFAKKA IFNSPLEAAM AFPHLQQPSF LLASLKADSI
        70         80         90        100        110        120
NKPFAQQCQD LVKVIEDFPA KELHTIFPWL VESIFGSLDG VLVGWNLRCL QGRVNPVEYS
       130        140        150        160        170        180
IVMEFLDPGG PMMKLVYKLQ AEDYKFDFPV SYLPGPVKAS IQECILPDSP LYHNKVQFTP
       190        200        210        220        230        240
TGGLGLNLAL NPFEYYIFFF ALSLITQKPL PVSLHVRTSD CAYFILVDRY LSWFLPTEGS
       250        260        270        280        290        300
VPPPLSSSPG GTSPSPPPRT PAIPFASYGL HHTSLLKRHI SHQTSVNADP ASHEIWRSET
       310        320        330        340        350        360
LLQVFVEMWL HHYSLEMYQK MQSPHAKLEV LHYRLSVSSA LYSPAQPSLQ ALHAYQESFT
       370        380        390        400        410        420
PTEEHVLVVR LLLKHLHAFA NSLKPEQASP SAHSHATSPL EEFKRAAVPR FVQQKLYLFL
       430        440        450        460        470        480
QHCFGHWPLD ASFRAVLEMW LSYLQPWRYA PDKQAPGSDS QPRCVSEKWA PFVQENLLMY
       490        500        510        520        530        540
TKLFVGFLNR ALRTDLVSPK HALMVFRVAK VFAQPNLAEM IQKGEQLFLE PELVIPHRQH
       550        560        570        580        590        600
RLFTAPTFTG SFLSPWPPAV TDASFKVKSH VYSLEGQDCK YTPMFGPEAR TLVLRLAQLI
       610        620        630        640        650        660
TQAKHTAKSI SDQCAESPAG HSFLSWLGFS SMDTNGSYTA NDLDEMGQDS VRKTDEYLEK
       670        680        690        700        710        720
ALEYLRQIFR LSEAQLRQFT LALGTTQDEN GKKQLPDCIV GEDGLILTPL GRYQIINGLR
       730        740        750        760        770        780
RFEIEYQGDP ELQPIRSYEI ASLVRTLFRL SSAINHRFAG QMAALCSRDD FLGSFCRYHL
       790        800        810        820        830        840
TEPGLASRHL LSPVGRRQVA GHTRGPRLSL RFLGSYRTLV SLLLAFFVAS LFCVGPLPCT
       850        860
LLLTLGYVLY ASAMTLLTER GKLHQP         10         20         30         40         50         60
MTTFGAVAEW RLPSLRRATL WIPQWFAKKA IFNSPLEAAM AFPHLQQPSF LLASLKADSI
        70         80         90        100        110        120
NKPFAQQCQD LVKVIEDFPA KELHTIFPWL VESIFGSLDG VLVGWNLRCL QGRVNPVEYS
       130        140        150        160        170        180
IVMEFLDPGG PMMKLVYKLQ AEDYKFDFPV SYLPGPVKAS IQECILPDSP LYHNKVQFTP
       190        200        210        220        230        240
TGGLGLNLAL NPFEYYIFFF ALSLITQKPL PVSLHVRTSD CAYFILVDRY LSWFLPTEGS
       250        260        270        280        290        300
VPPPLSSSPG GTSPSPPPRT PAIPFASYGL HHTSLLKRHI SHQTSVNADP ASHEIWRSET
       310        320        330        340        350        360
LLQVFVEMWL HHYSLEMYQK MQSPHAKLEV LHYRLSVSSA LYSPAQPSLQ ALHAYQESFT
       370        380        390        400        410        420
PTEEHVLVVR LLLKHLHAFA NSLKPEQASP SAHSHATSPL EEFKRAAVPR FVQQKLYLFL
       430        440        450        460        470        480
QHCFGHWPLD ASFRAVLEMW LSYLQPWRYA PDKQAPGSDS QPRCVSEKWA PFVQENLLMY
       490        500        510        520        530        540
TKLFVGFLNR ALRTDLVSPK HALMVFRVAK VFAQPNLAEM IQKGEQLFLE PELVIPHRQH
       550        560        570        580        590        600
RLFTAPTFTG SFLSPWPPAV TDASFKVKSH VYSLEGQDCK YTPMFGPEAR TLVLRLAQLI
       610        620        630        640        650        660
TQAKHTAKSI SDQCAESPAG HSFLSWLGFS SMDTNGSYTA NDLDEMGQDS VRKTDEYLEK
       670        680        690        700        710        720
ALEYLRQIFR LSEAQLRQFT LALGTTQDEN GKKQLPDCIV GEDGLILTPL GRYQIINGLR
       730        740        750        760        770        780
RFEIEYQGDP ELQPIRSYEI ASLVRTLFRL SSAINHRFAG QMAALCSRDD FLGSFCRYHL
       790        800        810        820        830        840
TEPGLASRHL LSPVGRRQVA GHTRGPRLSL RFLGSYRTLV SLLLAFFVAS LFCVGPLPCT
       850        860
LLLTLGYVLY ASAMTLLTER GKLHQP         10         20         30         40         50         60
MTTFGAVAEW RLPSLRRATL WIPQWFAKKA IFNSPLEAAM AFPHLQQPSF LLASLKADSI
        70         80         90        100        110        120
NKPFAQQCQD LVKVIEDFPA KELHTIFPWL VESIFGSLDG VLVGWNLRCL QGRVNPVEYS
       130        140        150        160        170        180
IVMEFLDPGG PMMKLVYKLQ AEDYKFDFPV SYLPGPVKAS IQECILPDSP LYHNKVQFTP
       190        200        210        220        230        240
TGGLGLNLAL NPFEYYIFFF ALSLITQKPL PVSLHVRTSD CAYFILVDRY LSWFLPTEGS
       250        260        270        280        290        300
VPPPLSSSPG GTSPSPPPRT PAIPFASYGL HHTSLLKRHI SHQTSVNADP ASHEIWRSET
       310        320        330        340        350        360
LLQVFVEMWL HHYSLEMYQK MQSPHAKLEV LHYRLSVSSA LYSPAQPSLQ ALHAYQESFT
       370        380        390        400        410        420
PTEEHVLVVR LLLKHLHAFA NSLKPEQASP SAHSHATSPL EEFKRAAVPR FVQQKLYLFL
       430        440        450        460        470        480
QHCFGHWPLD ASFRAVLEMW LSYLQPWRYA PDKQAPGSDS QPRCVSEKWA PFVQENLLMY
       490        500        510        520        530        540
TKLFVGFLNR ALRTDLVSPK HALMVFRVAK VFAQPNLAEM IQKGEQLFLE PELVIPHRQH
       550        560        570        580        590        600
RLFTAPTFTG SFLSPWPPAV TDASFKVKSH VYSLEGQDCK YTPMFGPEAR TLVLRLAQLI
       610        620        630        640        650        660
TQAKHTAKSI SDQCAESPAG HSFLSWLGFS SMDTNGSYTA NDLDEMGQDS VRKTDEYLEK
       670        680        690        700        710        720
ALEYLRQIFR LSEAQLRQFT LALGTTQDEN GKKQLPDCIV GEDGLILTPL GRYQIINGLR
       730        740        750        760        770        780
RFEIEYQGDP ELQPIRSYEI ASLVRTLFRL SSAINHRFAG QMAALCSRDD FLGSFCRYHL
       790        800        810        820        830        840
TEPGLASRHL LSPVGRRQVA GHTRGPRLSL RFLGSYRTLV SLLLAFFVAS LFCVGPLPCT
       850        860
LLLTLGYVLY ASAMTLLTER GKLHQP         10         20         30         40         50         60
MTTFGAVAEW RLPSLRRATL WIPQWFAKKA IFNSPLEAAM AFPHLQQPSF LLASLKADSI
        70         80         90        100        110        120
NKPFAQQCQD LVKVIEDFPA KELHTIFPWL VESIFGSLDG VLVGWNLRCL QGRVNPVEYS
       130        140        150        160        170        180
IVMEFLDPGG PMMKLVYKLQ AEDYKFDFPV SYLPGPVKAS IQECILPDSP LYHNKVQFTP
       190        200        210        220        230        240
TGGLGLNLAL NPFEYYIFFF ALSLITQKPL PVSLHVRTSD CAYFILVDRY LSWFLPTEGS
       250        260        270        280        290        300
VPPPLSSSPG GTSPSPPPRT PAIPFASYGL HHTSLLKRHI SHQTSVNADP ASHEIWRSET
       310        320        330        340        350        360
LLQVFVEMWL HHYSLEMYQK MQSPHAKLEV LHYRLSVSSA LYSPAQPSLQ ALHAYQESFT
       370        380        390        400        410        420
PTEEHVLVVR LLLKHLHAFA NSLKPEQASP SAHSHATSPL EEFKRAAVPR FVQQKLYLFL
       430        440        450        460        470        480
QHCFGHWPLD ASFRAVLEMW LSYLQPWRYA PDKQAPGSDS QPRCVSEKWA PFVQENLLMY
       490        500        510        520        530        540
TKLFVGFLNR ALRTDLVSPK HALMVFRVAK VFAQPNLAEM IQKGEQLFLE PELVIPHRQH
       550        560        570        580        590        600
RLFTAPTFTG SFLSPWPPAV TDASFKVKSH VYSLEGQDCK YTPMFGPEAR TLVLRLAQLI
       610        620        630        640        650        660
TQAKHTAKSI SDQCAESPAG HSFLSWLGFS SMDTNGSYTA NDLDEMGQDS VRKTDEYLEK
       670        680        690        700        710        720
ALEYLRQIFR LSEAQLRQFT LALGTTQDEN GKKQLPDCIV GEDGLILTPL GRYQIINGLR
       730        740        750        760        770        780
RFEIEYQGDP ELQPIRSYEI ASLVRTLFRL SSAINHRFAG QMAALCSRDD FLGSFCRYHL
       790        800        810        820        830        840
TEPGLASRHL LSPVGRRQVA GHTRGPRLSL RFLGSYRTLV SLLLAFFVAS LFCVGPLPCT
       850        860
LLLTLGYVLY ASAMTLLTER GKLHQP         10         20         30         40         50         60
MTTFGAVAEW RLPSLRRATL WIPQWFAKKA IFNSPLEAAM AFPHLQQPSF LLASLKADSI
        70         80         90        100        110        120
NKPFAQQCQD LVKVIEDFPA KELHTIFPWL VESIFGSLDG VLVGWNLRCL QGRVNPVEYS
       130        140        150        160        170        180
IVMEFLDPGG PMMKLVYKLQ AEDYKFDFPV SYLPGPVKAS IQECILPDSP LYHNKVQFTP
       190        200        210        220        230        240
TGGLGLNLAL NPFEYYIFFF ALSLITQKPL PVSLHVRTSD CAYFILVDRY LSWFLPTEGS
       250        260        270        280        290        300
VPPPLSSSPG GTSPSPPPRT PAIPFASYGL HHTSLLKRHI SHQTSVNADP ASHEIWRSET
       310        320        330        340        350        360
LLQVFVEMWL HHYSLEMYQK MQSPHAKLEV LHYRLSVSSA LYSPAQPSLQ ALHAYQESFT
       370        380        390        400        410        420
PTEEHVLVVR LLLKHLHAFA NSLKPEQASP SAHSHATSPL EEFKRAAVPR FVQQKLYLFL
       430        440        450        460        470        480
QHCFGHWPLD ASFRAVLEMW LSYLQPWRYA PDKQAPGSDS QPRCVSEKWA PFVQENLLMY
       490        500        510        520        530        540
TKLFVGFLNR ALRTDLVSPK HALMVFRVAK VFAQPNLAEM IQKGEQLFLE PELVIPHRQH
       550        560        570        580        590        600
RLFTAPTFTG SFLSPWPPAV TDASFKVKSH VYSLEGQDCK YTPMFGPEAR TLVLRLAQLI
       610        620        630        640        650        660
TQAKHTAKSI SDQCAESPAG HSFLSWLGFS SMDTNGSYTA NDLDEMGQDS VRKTDEYLEK
       670        680        690        700        710        720
ALEYLRQIFR LSEAQLRQFT LALGTTQDEN GKKQLPDCIV GEDGLILTPL GRYQIINGLR
       730        740        750        760        770        780
RFEIEYQGDP ELQPIRSYEI ASLVRTLFRL SSAINHRFAG QMAALCSRDD FLGSFCRYHL
       790        800        810        820        830        840
TEPGLASRHL LSPVGRRQVA GHTRGPRLSL RFLGSYRTLV SLLLAFFVAS LFCVGPLPCT
       850        860
LLLTLGYVLY ASAMTLLTER GKLHQP         10         20         30         40         50         60
MTTFGAVAEW RLPSLRRATL WIPQWFAKKA IFNSPLEAAM AFPHLQQPSF LLASLKADSI
        70         80         90        100        110        120
NKPFAQQCQD LVKVIEDFPA KELHTIFPWL VESIFGSLDG VLVGWNLRCL QGRVNPVEYS
       130        140        150        160        170        180
IVMEFLDPGG PMMKLVYKLQ AEDYKFDFPV SYLPGPVKAS IQECILPDSP LYHNKVQFTP
       190        200        210        220        230        240
TGGLGLNLAL NPFEYYIFFF ALSLITQKPL PVSLHVRTSD CAYFILVDRY LSWFLPTEGS
       250        260        270        280        290        300
VPPPLSSSPG GTSPSPPPRT PAIPFASYGL HHTSLLKRHI SHQTSVNADP ASHEIWRSET
       310        320        330        340        350        360
LLQVFVEMWL HHYSLEMYQK MQSPHAKLEV LHYRLSVSSA LYSPAQPSLQ ALHAYQESFT
       370        380        390        400        410        420
PTEEHVLVVR LLLKHLHAFA NSLKPEQASP SAHSHATSPL EEFKRAAVPR FVQQKLYLFL
       430        440        450        460        470        480
QHCFGHWPLD ASFRAVLEMW LSYLQPWRYA PDKQAPGSDS QPRCVSEKWA PFVQENLLMY
       490        500        510        520        530        540
TKLFVGFLNR ALRTDLVSPK HALMVFRVAK VFAQPNLAEM IQKGEQLFLE PELVIPHRQH
       550        560        570        580        590        600
RLFTAPTFTG SFLSPWPPAV TDASFKVKSH VYSLEGQDCK YTPMFGPEAR TLVLRLAQLI
       610        620        630        640        650        660
TQAKHTAKSI SDQCAESPAG HSFLSWLGFS SMDTNGSYTA NDLDEMGQDS VRKTDEYLEK
       670        680        690        700        710        720
ALEYLRQIFR LSEAQLRQFT LALGTTQDEN GKKQLPDCIV GEDGLILTPL GRYQIINGLR
       730        740        750        760        770        780
RFEIEYQGDP ELQPIRSYEI ASLVRTLFRL SSAINHRFAG QMAALCSRDD FLGSFCRYHL
       790        800        810        820        830        840
TEPGLASRHL LSPVGRRQVA GHTRGPRLSL RFLGSYRTLV SLLLAFFVAS LFCVGPLPCT
       850        860
LLLTLGYVLY ASAMTLLTER GKLHQP         10         20         30         40         50         60
MTTFGAVAEW RLPSLRRATL WIPQWFAKKA IFNSPLEAAM AFPHLQQPSF LLASLKADSI
        70         80         90        100        110        120
NKPFAQQCQD LVKVIEDFPA KELHTIFPWL VESIFGSLDG VLVGWNLRCL QGRVNPVEYS
       130        140        150        160        170        180
IVMEFLDPGG PMMKLVYKLQ AEDYKFDFPV SYLPGPVKAS IQECILPDSP LYHNKVQFTP
       190        200        210        220        230        240
TGGLGLNLAL NPFEYYIFFF ALSLITQKPL PVSLHVRTSD CAYFILVDRY LSWFLPTEGS
       250        260        270        280        290        300
VPPPLSSSPG GTSPSPPPRT PAIPFASYGL HHTSLLKRHI SHQTSVNADP ASHEIWRSET
       310        320        330        340        350        360
LLQVFVEMWL HHYSLEMYQK MQSPHAKLEV LHYRLSVSSA LYSPAQPSLQ ALHAYQESFT
       370        380        390        400        410        420
PTEEHVLVVR LLLKHLHAFA NSLKPEQASP SAHSHATSPL EEFKRAAVPR FVQQKLYLFL
       430        440        450        460        470        480
QHCFGHWPLD ASFRAVLEMW LSYLQPWRYA PDKQAPGSDS QPRCVSEKWA PFVQENLLMY
       490        500        510        520        530        540
TKLFVGFLNR ALRTDLVSPK HALMVFRVAK VFAQPNLAEM IQKGEQLFLE PELVIPHRQH
       550        560        570        580        590        600
RLFTAPTFTG SFLSPWPPAV TDASFKVKSH VYSLEGQDCK YTPMFGPEAR TLVLRLAQLI
       610        620        630        640        650        660
TQAKHTAKSI SDQCAESPAG HSFLSWLGFS SMDTNGSYTA NDLDEMGQDS VRKTDEYLEK
       670        680        690        700        710        720
ALEYLRQIFR LSEAQLRQFT LALGTTQDEN GKKQLPDCIV GEDGLILTPL GRYQIINGLR
       730        740        750        760        770        780
RFEIEYQGDP ELQPIRSYEI ASLVRTLFRL SSAINHRFAG QMAALCSRDD FLGSFCRYHL
       790        800        810        820        830        840
TEPGLASRHL LSPVGRRQVA GHTRGPRLSL RFLGSYRTLV SLLLAFFVAS LFCVGPLPCT
       850        860
LLLTLGYVLY ASAMTLLTER GKLHQP         10         20         30         40         50         60
MTTFGAVAEW RLPSLRRATL WIPQWFAKKA IFNSPLEAAM AFPHLQQPSF LLASLKADSI
        70         80         90        100        110        120
NKPFAQQCQD LVKVIEDFPA KELHTIFPWL VESIFGSLDG VLVGWNLRCL QGRVNPVEYS
       130        140        150        160        170        180
IVMEFLDPGG PMMKLVYKLQ AEDYKFDFPV SYLPGPVKAS IQECILPDSP LYHNKVQFTP
       190        200        210        220        230        240
TGGLGLNLAL NPFEYYIFFF ALSLITQKPL PVSLHVRTSD CAYFILVDRY LSWFLPTEGS
       250        260        270        280        290        300
VPPPLSSSPG GTSPSPPPRT PAIPFASYGL HHTSLLKRHI SHQTSVNADP ASHEIWRSET
       310        320        330        340        350        360
LLQVFVEMWL HHYSLEMYQK MQSPHAKLEV LHYRLSVSSA LYSPAQPSLQ ALHAYQESFT
       370        380        390        400        410        420
PTEEHVLVVR LLLKHLHAFA NSLKPEQASP SAHSHATSPL EEFKRAAVPR FVQQKLYLFL
       430        440        450        460        470        480
QHCFGHWPLD ASFRAVLEMW LSYLQPWRYA PDKQAPGSDS QPRCVSEKWA PFVQENLLMY
       490        500        510        520        530        540
TKLFVGFLNR ALRTDLVSPK HALMVFRVAK VFAQPNLAEM IQKGEQLFLE PELVIPHRQH
       550        560        570        580        590        600
RLFTAPTFTG SFLSPWPPAV TDASFKVKSH VYSLEGQDCK YTPMFGPEAR TLVLRLAQLI
       610        620        630        640        650        660
TQAKHTAKSI SDQCAESPAG HSFLSWLGFS SMDTNGSYTA NDLDEMGQDS VRKTDEYLEK
       670        680        690        700        710        720
ALEYLRQIFR LSEAQLRQFT LALGTTQDEN GKKQLPDCIV GEDGLILTPL GRYQIINGLR
       730        740        750        760        770        780
RFEIEYQGDP ELQPIRSYEI ASLVRTLFRL SSAINHRFAG QMAALCSRDD FLGSFCRYHL
       790        800        810        820        830        840
TEPGLASRHL LSPVGRRQVA GHTRGPRLSL RFLGSYRTLV SLLLAFFVAS LFCVGPLPCT
       850        860
LLLTLGYVLY ASAMTLLTER GKLHQP         10         20         30         40         50         60
MTTFGAVAEW RLPSLRRATL WIPQWFAKKA IFNSPLEAAM AFPHLQQPSF LLASLKADSI
        70         80         90        100        110        120
NKPFAQQCQD LVKVIEDFPA KELHTIFPWL VESIFGSLDG VLVGWNLRCL QGRVNPVEYS
       130        140        150        160        170        180
IVMEFLDPGG PMMKLVYKLQ AEDYKFDFPV SYLPGPVKAS IQECILPDSP LYHNKVQFTP
       190        200        210        220        230        240
TGGLGLNLAL NPFEYYIFFF ALSLITQKPL PVSLHVRTSD CAYFILVDRY LSWFLPTEGS
       250        260        270        280        290        300
VPPPLSSSPG GTSPSPPPRT PAIPFASYGL HHTSLLKRHI SHQTSVNADP ASHEIWRSET
       310        320        330        340        350        360
LLQVFVEMWL HHYSLEMYQK MQSPHAKLEV LHYRLSVSSA LYSPAQPSLQ ALHAYQESFT
       370        380        390        400        410        420
PTEEHVLVVR LLLKHLHAFA NSLKPEQASP SAHSHATSPL EEFKRAAVPR FVQQKLYLFL
       430        440        450        460        470        480
QHCFGHWPLD ASFRAVLEMW LSYLQPWRYA PDKQAPGSDS QPRCVSEKWA PFVQENLLMY
       490        500        510        520        530        540
TKLFVGFLNR ALRTDLVSPK HALMVFRVAK VFAQPNLAEM IQKGEQLFLE PELVIPHRQH
       550        560        570        580        590        600
RLFTAPTFTG SFLSPWPPAV TDASFKVKSH VYSLEGQDCK YTPMFGPEAR TLVLRLAQLI
       610        620        630        640        650        660
TQAKHTAKSI SDQCAESPAG HSFLSWLGFS SMDTNGSYTA NDLDEMGQDS VRKTDEYLEK
       670        680        690        700        710        720
ALEYLRQIFR LSEAQLRQFT LALGTTQDEN GKKQLPDCIV GEDGLILTPL GRYQIINGLR
       730        740        750        760        770        780
RFEIEYQGDP ELQPIRSYEI ASLVRTLFRL SSAINHRFAG QMAALCSRDD FLGSFCRYHL
       790        800        810        820        830        840
TEPGLASRHL LSPVGRRQVA GHTRGPRLSL RFLGSYRTLV SLLLAFFVAS LFCVGPLPCT
       850        860
LLLTLGYVLY ASAMTLLTER GKLHQP         10         20         30         40         50         60
MTTFGAVAEW RLPSLRRATL WIPQWFAKKA IFNSPLEAAM AFPHLQQPSF LLASLKADSI
        70         80         90        100        110        120
NKPFAQQCQD LVKVIEDFPA KELHTIFPWL VESIFGSLDG VLVGWNLRCL QGRVNPVEYS
       130        140        150        160        170        180
IVMEFLDPGG PMMKLVYKLQ AEDYKFDFPV SYLPGPVKAS IQECILPDSP LYHNKVQFTP
       190        200        210        220        230        240
TGGLGLNLAL NPFEYYIFFF ALSLITQKPL PVSLHVRTSD CAYFILVDRY LSWFLPTEGS
       250        260        270        280        290        300
VPPPLSSSPG GTSPSPPPRT PAIPFASYGL HHTSLLKRHI SHQTSVNADP ASHEIWRSET
       310        320        330        340        350        360
LLQVFVEMWL HHYSLEMYQK MQSPHAKLEV LHYRLSVSSA LYSPAQPSLQ ALHAYQESFT
       370        380        390        400        410        420
PTEEHVLVVR LLLKHLHAFA NSLKPEQASP SAHSHATSPL EEFKRAAVPR FVQQKLYLFL
       430        440        450        460        470        480
QHCFGHWPLD ASFRAVLEMW LSYLQPWRYA PDKQAPGSDS QPRCVSEKWA PFVQENLLMY
       490        500        510        520        530        540
TKLFVGFLNR ALRTDLVSPK HALMVFRVAK VFAQPNLAEM IQKGEQLFLE PELVIPHRQH
       550        560        570        580        590        600
RLFTAPTFTG SFLSPWPPAV TDASFKVKSH VYSLEGQDCK YTPMFGPEAR TLVLRLAQLI
       610        620        630        640        650        660
TQAKHTAKSI SDQCAESPAG HSFLSWLGFS SMDTNGSYTA NDLDEMGQDS VRKTDEYLEK
       670        680        690        700        710        720
ALEYLRQIFR LSEAQLRQFT LALGTTQDEN GKKQLPDCIV GEDGLILTPL GRYQIINGLR
       730        740        750        760        770        780
RFEIEYQGDP ELQPIRSYEI ASLVRTLFRL SSAINHRFAG QMAALCSRDD FLGSFCRYHL
       790        800        810        820        830        840
TEPGLASRHL LSPVGRRQVA GHTRGPRLSL RFLGSYRTLV SLLLAFFVAS LFCVGPLPCT
       850        860
LLLTLGYVLY ASAMTLLTER GKLHQP         10         20         30         40         50         60
MTTFGAVAEW RLPSLRRATL WIPQWFAKKA IFNSPLEAAM AFPHLQQPSF LLASLKADSI
        70         80         90        100        110        120
NKPFAQQCQD LVKVIEDFPA KELHTIFPWL VESIFGSLDG VLVGWNLRCL QGRVNPVEYS
       130        140        150        160        170        180
IVMEFLDPGG PMMKLVYKLQ AEDYKFDFPV SYLPGPVKAS IQECILPDSP LYHNKVQFTP
       190        200        210        220        230        240
TGGLGLNLAL NPFEYYIFFF ALSLITQKPL PVSLHVRTSD CAYFILVDRY LSWFLPTEGS
       250        260        270        280        290        300
VPPPLSSSPG GTSPSPPPRT PAIPFASYGL HHTSLLKRHI SHQTSVNADP ASHEIWRSET
       310        320        330        340        350        360
LLQVFVEMWL HHYSLEMYQK MQSPHAKLEV LHYRLSVSSA LYSPAQPSLQ ALHAYQESFT
       370        380        390        400        410        420
PTEEHVLVVR LLLKHLHAFA NSLKPEQASP SAHSHATSPL EEFKRAAVPR FVQQKLYLFL
       430        440        450        460        470        480
QHCFGHWPLD ASFRAVLEMW LSYLQPWRYA PDKQAPGSDS QPRCVSEKWA PFVQENLLMY
       490        500        510        520        530        540
TKLFVGFLNR ALRTDLVSPK HALMVFRVAK VFAQPNLAEM IQKGEQLFLE PELVIPHRQH
       550        560        570        580        590        600
RLFTAPTFTG SFLSPWPPAV TDASFKVKSH VYSLEGQDCK YTPMFGPEAR TLVLRLAQLI
       610        620        630        640        650        660
TQAKHTAKSI SDQCAESPAG HSFLSWLGFS SMDTNGSYTA NDLDEMGQDS VRKTDEYLEK
       670        680        690        700        710        720
ALEYLRQIFR LSEAQLRQFT LALGTTQDEN GKKQLPDCIV GEDGLILTPL GRYQIINGLR
       730        740        750        760        770        780
RFEIEYQGDP ELQPIRSYEI ASLVRTLFRL SSAINHRFAG QMAALCSRDD FLGSFCRYHL
       790        800        810        820        830        840
TEPGLASRHL LSPVGRRQVA GHTRGPRLSL RFLGSYRTLV SLLLAFFVAS LFCVGPLPCT
       850        860
LLLTLGYVLY ASAMTLLTER GKLHQP

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 6 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9NXE4-1-unknown	MTTFGA...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9NXE4-1-unknown	MTTFGA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt83358
Q9NXE4-1-unknown	MTTFGA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt83360
Q9NXE4-1-unknown	MTTFGA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt102880
Q9NXE4-1-unknown	MTTFGA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt102881
Q9NXE4-1-unknown	MTTFGA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt83362
Q9NXE4-1-unknown	MTTFGA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt83364
Q9NXE4-93-unknown	SIFGSL...	93	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt83359
Q9NXE4-93-unknown	SIFGSL...	93	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt104759
Q9NXE4-93-unknown	SIFGSL...	93	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt104760
Q9NXE4-185-unknown	GLNLAL...	185	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000405363
Q9NXE4-185-unknown	GLNLAL...	185	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt131920
Q9NXE4-185-unknown	GLNLAL...	185	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt131922
Q9NXE4-185-unknown	GLNLAL...	185	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt131919
Q9NXE4-185-unknown	GLNLAL...	185	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt131921
Q9NXE4-269-unknown	GLHHTS...	269	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000391896
Q9NXE4-269-unknown	GLHHTS...	269	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt131925
Q9NXE4-269-unknown	GLHHTS...	269	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt131926
Q9NXE4-365-unknown	HVLVVR...	365	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000397078
Q9NXE4-365-unknown	HVLVVR...	365	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt131908
Q9NXE4-365-unknown	HVLVVR...	365	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt131909
Q9NXE4-365-unknown	HVLVVR...	365	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt131906
Q9NXE4-365-unknown	HVLVVR...	365	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt131907
Q9NXE4-365-unknown	HVLVVR...	365	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt131905
Q9NXE4-426-unknown	HWPLDA...	426	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000403915
Q9NXE4-426-unknown	HWPLDA...	426	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt131917
Q9NXE4-426-unknown	HWPLDA...	426	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt131915
Q9NXE4-426-unknown	HWPLDA...	426	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt131916
Q9NXE4-426-unknown	HWPLDA...	426	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt131912
Q9NXE4-426-unknown	HWPLDA...	426	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt131914
Q9NXE4-426-unknown	HWPLDA...	426	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt131911
Q9NXE4-426-unknown	HWPLDA...	426	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt131913

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PMMKLV	135	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000406458
...PMMKLV	135	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112743
...PMMKLV	135	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112742
...PMMKLV	135	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112744
...YTKLFV	484	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000405363
...YTKLFV	484	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112740
...TGSFLS	553	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000406325
...TGSFLS	553	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112728
...LEKALE	662	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000403915
...GQMAAL	764	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000397078
...LLAFFV	827	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LLAFFV	827	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78979
...LLAFFV	827	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78983
...LLAFFV	827	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78981
...LLAFFV	827	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78982
...LLAFFV	827	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78977
...LLAFFV	827	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78980
...LLAFFV	827	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78976
...LLAFFV	827	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78978

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)