Q9NXG6: Transmembrane prolyl 4-hydroxylase

General Information

Protein names	- Transmembrane prolyl 4-hydroxylase - P4H-TM - 1.14.11.29 {ECO:0000269\|PubMed:17726031} - Hypoxia-inducible factor prolyl hydroxylase 4 - HIF-PH4 - HIF-prolyl hydroxylase 4 - HPH-4
Gene names	P4HTM
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9NXG6

3 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Transmembrane prolyl 4-hydroxylase - Isoform 3 of Transmembrane prolyl 4-hydroxylase

Sequence View

        10         20         30         40         50         60
MAAAAVTGQR PETAAAEEAS RPQWAPPDHC QAQAAAGLGD GEDAPVRPLC KPRGICSRAY
        70         80         90        100        110        120
FLVLMVFVHL YLGNVLALLL FVHYSNGDES SDPGPQHRAQ GPGPEPTLGP LTRLEGIKVG
       130        140        150        160        170        180
HERKVQLVTD RDHFIRTLSL KPLLFEIPGF LTDEECRLII HLAQMKGLQR SQILPTEEYE
       190        200        210        220        230        240
EAMSTMQVSQ LDLFRLLDQN RDGHLQLREV LAQTRLGNGW WMTPESIQEM YAAIKADPDG
       250        260        270        280        290        300
DGVLSLQEFS NMDLRDFHKY MRSHKAESSE LVRNSHHTWL YQGEGAHHIM RAIRQRVLRL
       310        320        330        340        350        360
TRLSPEIVEL SEPLQVVRYG EGGHYHAHVD SGPVYPETIC SHTKLVANES VPFETSCRYM
       370        380        390        400        410        420
TVLFYLNNVT GGGETVFPVA DNRTYDEMSL IQDDVDLRDT RRHCDKGNLR VKPQQGTAVF
       430        440        450        460        470        480
WYNYLPDGQG WVGDVDDYSL HGGCLVTRGT KWIANNWINV DPSRARQALF QQEMARLARE
       490        500
GGTDSQPEWA LDRAYRDARV EL         10         20         30         40         50         60
MAAAAVTGQR PETAAAEEAS RPQWAPPDHC QAQAAAGLGD GEDAPVRPLC KPRGICSRAY
        70         80         90        100        110        120
FLVLMVFVHL YLGNVLALLL FVHYSNGDES SDPGPQHRAQ GPGPEPTLGP LTRLEGIKVG
       130        140        150        160        170        180
HERKVQLVTD RDHFIRTLSL KPLLFEIPGF LTDEECRLII HLAQMKGLQR SQILPTEEYE
       190        200        210        220        230        240
EAMSTMQVSQ LDLFRLLDQN RDGHLQLREV LAQTRLGNGW WMTPESIQEM YAAIKADPDG
       250        260        270        280        290        300
DGVLSLQEFS NMDLRDFHKY MRSHKAESSE LVRNSHHTWL YQGEGAHHIM RAIRQRVLRL
       310        320        330        340        350        360
TRLSPEIVEL SEPLQVVRYG EGGHYHAHVD SGPVYPETIC SHTKLVANES VPFETSCRYM
       370        380        390        400        410        420
TVLFYLNNVT GGGETVFPVA DNRTYDEMSL IQDDVDLRDT RRHCDKGNLR VKPQQGTAVF
       430        440        450        460        470        480
WYNYLPDGQG WVGDVDDYSL HGGCLVTRGT KWIANNWINV DPSRARQALF QQEMARLARE
       490        500
GGTDSQPEWA LDRAYRDARV EL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9NXG6-1-unknown	MAAAAV...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9NXG6-1-unknown	MAAAAV...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt84049
Q9NXG6-1-unknown	MAAAAV...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt84050
Q9NXG6-28-unknown	DHCQAQ...	28	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000477191
Q9NXG6-28-unknown	DHCQAQ...	28	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt195556
Q9NXG6-28-unknown	DHCQAQ...	28	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt195557
Q9NXG6-209-unknown	EVLAQT...	209	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000476858
Q9NXG6-209-unknown	EVLAQT...	209	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt198134
Q9NXG6-209-unknown	EVLAQT...	209	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt198135

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...AIRQRV	296	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000398554
...AIRQRV	296	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000476858
...ARVEL	502	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...ARVEL	502	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79668

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)