TopFIND 4.0

Q9NYZ4: Sialic acid-binding Ig-like lectin 8

General Information

Protein names
- Sialic acid-binding Ig-like lectin 8
- Siglec-8
- Sialoadhesin family member 2
- SAF-2
Gene names SIGLEC8
Organism Homo sapiens
Protease Family
Protease ID I43.001
Chromosome location
UniProt ID Q9NYZ4

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MLLLLLLLPL LWGTKGMEGD RQYGDGYLLQ VQELVTVQEG LCVHVPCSFS YPQDGWTDSD 
        70         80         90        100        110        120 
PVHGYWFRAG DRPYQDAPVA TNNPDREVQA ETQGRFQLLG DIWSNDCSLS IRDARKRDKG 
       130        140        150        160        170        180 
SYFFRLERGS MKWSYKSQLN YKTKQLSVFV TALTHRPDIL ILGTLESGHS RNLTCSVPWA 
       190        200        210        220        230        240 
CKQGTPPMIS WIGASVSSPG PTTARSSVLT LTPKPQDHGT SLTCQVTLPG TGVTTTSTVR 
       250        260        270        280        290        300 
LDVSYPPWNL TMTVFQGDAT ASTALGNGSS LSVLEGQSLR LVCAVNSNPP ARLSWTRGSL 
       310        320        330        340        350        360 
TLCPSRSSNP GLLELPRVHV RDEGEFTCRA QNAQGSQHIS LSLSLQNEGT GTSRPVSQVT 
       370        380        390        400        410        420 
LAAVGGAGAT ALAFLSFCII FIIVRSCRKK SARPAAGVGD TGMEDAKAIR GSASQGPLTE 
       430        440        450        460        470        480 
SWKDGNPLKK PPPAVAPSSG EEGELHYATL SFHKVKPQDP QGQEATDSEY SEIKIHKRET 
       490    
AETQACLRNH NPSSKEVRG

Isoforms

- Isoform 2 of Sialic acid-binding Ig-like lectin 8 - Isoform 3 of Sialic acid-binding Ig-like lectin 8

Sequence View

        10         20         30         40         50         60 
MLLLLLLLPL LWGTKGMEGD RQYGDGYLLQ VQELVTVQEG LCVHVPCSFS YPQDGWTDSD 
        70         80         90        100        110        120 
PVHGYWFRAG DRPYQDAPVA TNNPDREVQA ETQGRFQLLG DIWSNDCSLS IRDARKRDKG 
       130        140        150        160        170        180 
SYFFRLERGS MKWSYKSQLN YKTKQLSVFV TALTHRPDIL ILGTLESGHS RNLTCSVPWA 
       190        200        210        220        230        240 
CKQGTPPMIS WIGASVSSPG PTTARSSVLT LTPKPQDHGT SLTCQVTLPG TGVTTTSTVR 
       250        260        270        280        290        300 
LDVSYPPWNL TMTVFQGDAT ASTALGNGSS LSVLEGQSLR LVCAVNSNPP ARLSWTRGSL 
       310        320        330        340        350        360 
TLCPSRSSNP GLLELPRVHV RDEGEFTCRA QNAQGSQHIS LSLSLQNEGT GTSRPVSQVT 
       370        380        390        400        410        420 
LAAVGGAGAT ALAFLSFCII FIIVRSCRKK SARPAAGVGD TGMEDAKAIR GSASQGPLTE 
       430        440        450        460        470        480 
SWKDGNPLKK PPPAVAPSSG EEGELHYATL SFHKVKPQDP QGQEATDSEY SEIKIHKRET 
       490    
AETQACLRNH NPSSKEVRG         10         20         30         40         50         60 
MLLLLLLLPL LWGTKGMEGD RQYGDGYLLQ VQELVTVQEG LCVHVPCSFS YPQDGWTDSD 
        70         80         90        100        110        120 
PVHGYWFRAG DRPYQDAPVA TNNPDREVQA ETQGRFQLLG DIWSNDCSLS IRDARKRDKG 
       130        140        150        160        170        180 
SYFFRLERGS MKWSYKSQLN YKTKQLSVFV TALTHRPDIL ILGTLESGHS RNLTCSVPWA 
       190        200        210        220        230        240 
CKQGTPPMIS WIGASVSSPG PTTARSSVLT LTPKPQDHGT SLTCQVTLPG TGVTTTSTVR 
       250        260        270        280        290        300 
LDVSYPPWNL TMTVFQGDAT ASTALGNGSS LSVLEGQSLR LVCAVNSNPP ARLSWTRGSL 
       310        320        330        340        350        360 
TLCPSRSSNP GLLELPRVHV RDEGEFTCRA QNAQGSQHIS LSLSLQNEGT GTSRPVSQVT 
       370        380        390        400        410        420 
LAAVGGAGAT ALAFLSFCII FIIVRSCRKK SARPAAGVGD TGMEDAKAIR GSASQGPLTE 
       430        440        450        460        470        480 
SWKDGNPLKK PPPAVAPSSG EEGELHYATL SFHKVKPQDP QGQEATDSEY SEIKIHKRET 
       490    
AETQACLRNH NPSSKEVRG



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


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Lab:



Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...KEVRG 499 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...KEVRG 499 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt85373

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)