Q9NZH6: Interleukin-37

General Information

Protein names	- Interleukin-37 - FIL1 zeta - IL-1X - Interleukin-1 family member 7 - IL-1F7 - Interleukin-1 homolog 4 - IL-1H - IL-1H4 - Interleukin-1 zeta - IL-1 zeta - Interleukin-1-related protein - IL-1RP1 - Interleukin-23 - IL-37
Gene names	IL37
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9NZH6

3 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform A of Interleukin-37 - Isoform C of Interleukin-37 - Isoform D of Interleukin-37 - Isoform E of Interleukin-37

Sequence View

        10         20         30         40         50         60
MSFVGENSGV KMGSEDWEKD EPQCCLEDPA GSPLEPGPSL PTMNFVHTSP KVKNLNPKKF
        70         80         90        100        110        120
SIHDQDHKVL VLDSGNLIAV PDKNYIRPEI FFALASSLSS ASAEKGSPIL LGVSKGEFCL
       130        140        150        160        170        180
YCDKDKGQSH PSLQLKKEKL MKLAAQKESA RRPFIFYRAQ VGSWNMLESA AHPGWFICTS
       190        200        210
CNCNEPVGVT DKFENRKHIE FSFQPVCKAE MSPSEVSD         10         20         30         40         50         60
MSFVGENSGV KMGSEDWEKD EPQCCLEDPA GSPLEPGPSL PTMNFVHTSP KVKNLNPKKF
        70         80         90        100        110        120
SIHDQDHKVL VLDSGNLIAV PDKNYIRPEI FFALASSLSS ASAEKGSPIL LGVSKGEFCL
       130        140        150        160        170        180
YCDKDKGQSH PSLQLKKEKL MKLAAQKESA RRPFIFYRAQ VGSWNMLESA AHPGWFICTS
       190        200        210
CNCNEPVGVT DKFENRKHIE FSFQPVCKAE MSPSEVSD         10         20         30         40         50         60
MSFVGENSGV KMGSEDWEKD EPQCCLEDPA GSPLEPGPSL PTMNFVHTSP KVKNLNPKKF
        70         80         90        100        110        120
SIHDQDHKVL VLDSGNLIAV PDKNYIRPEI FFALASSLSS ASAEKGSPIL LGVSKGEFCL
       130        140        150        160        170        180
YCDKDKGQSH PSLQLKKEKL MKLAAQKESA RRPFIFYRAQ VGSWNMLESA AHPGWFICTS
       190        200        210
CNCNEPVGVT DKFENRKHIE FSFQPVCKAE MSPSEVSD         10         20         30         40         50         60
MSFVGENSGV KMGSEDWEKD EPQCCLEDPA GSPLEPGPSL PTMNFVHTSP KVKNLNPKKF
        70         80         90        100        110        120
SIHDQDHKVL VLDSGNLIAV PDKNYIRPEI FFALASSLSS ASAEKGSPIL LGVSKGEFCL
       130        140        150        160        170        180
YCDKDKGQSH PSLQLKKEKL MKLAAQKESA RRPFIFYRAQ VGSWNMLESA AHPGWFICTS
       190        200        210
CNCNEPVGVT DKFENRKHIE FSFQPVCKAE MSPSEVSD

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9NZH6-1-unknown	MSFVGE...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt77784
Q9NZH6-1-unknown	MSFVGE...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt77785
Q9NZH6-1-unknown	MSFVGE...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt77786
Q9NZH6-21-unknown	EPQCCL...	21	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1351
Q9NZH6-21-unknown	EPQCCL...	21	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt136915
Q9NZH6-46-unknown	VHTSPK...	46	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DWEKDE	20	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1351
...SEVSD	218	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SEVSD	218	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73404
...SEVSD	218	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73402
...SEVSD	218	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73401
...SEVSD	218	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73403

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP1_HUMAN	20	EKDE.\|.EPQC	inferred from experiment	unknown	MEROPS	Lotze MT	Kumar S et al.:Interleukin-1F7B (IL-1H4/IL-1F7... (C14.001)	12096920,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)