Q9NZJ9: Diphosphoinositol polyphosphate phosphohydrolase 2 {ECO:0000305}

General Information

Protein names	- Diphosphoinositol polyphosphate phosphohydrolase 2 {ECO:0000305} - DIPP-2 - 3.6.1.52 {ECO:0000269\|PubMed:10777568, ECO:0000269\|PubMed:12370170} - Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 2 - Nucleoside diphosphate-linked moiety X motif 4 - Nudix motif 4
Gene names	NUDT4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9NZJ9

4 N-termini

3 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Diphosphoinositol polyphosphate phosphohydrolase 2 - Isoform 3 of Diphosphoinositol polyphosphate phosphohydrolase 2

Sequence View

        10         20         30         40         50         60
MMKFKPNQTR TYDREGFKKR AACLCFRSEQ EDEVLLVSSS RYPDQWIVPG GGMEPEEEPG
        70         80         90        100        110        120
GAAVREVYEE AGVKGKLGRL LGIFENQDRK HRTYVYVLTV TEILEDWEDS VNIGRKREWF
       130        140        150        160        170        180
KVEDAIKVLQ CHKPVHAEYL EKLKLGCSPA NGNSTVPSLP DNNALFVTAA QTSGLPSSVR

        10         20         30         40         50         60
MMKFKPNQTR TYDREGFKKR AACLCFRSEQ EDEVLLVSSS RYPDQWIVPG GGMEPEEEPG
        70         80         90        100        110        120
GAAVREVYEE AGVKGKLGRL LGIFENQDRK HRTYVYVLTV TEILEDWEDS VNIGRKREWF
       130        140        150        160        170        180
KVEDAIKVLQ CHKPVHAEYL EKLKLGCSPA NGNSTVPSLP DNNALFVTAA QTSGLPSSVR

Filter Information:

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9NZJ9-1-unknown	MMKFKP...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt83517
Q9NZJ9-1-Acetylation	MMKFKP...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9NZJ9-1-Acetylation	MMKFKP...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9NZJ9-1-Acetylation	MMKFKP...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9NZJ9-1-Acetylation	MMKFKP...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt108411
Q9NZJ9-2-unknown	MKFKPN...	2			COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9NZJ9-2-unknown	MKFKPN...	2			COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9NZJ9-2-unknown	MKFKPN...	2		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162538
Q9NZJ9-53-unknown	MEPEEE...	53		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt83518
Q9NZJ9-53-unknown	MEPEEE...	53		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000448504
Q9NZJ9-53-unknown	MEPEEE...	53		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000449552
Q9NZJ9-53-unknown	MEPEEE...	53		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000449724
Q9NZJ9-53-unknown	MEPEEE...	53		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000448032
Q9NZJ9-53-unknown	MEPEEE...	53		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000448620
Q9NZJ9-53-unknown	MEPEEE...	53		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt99332

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LKLGCS	147	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000448504
...LKLGCS	147	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154926
...LKLGCS	147	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154927
...PDNNAL	164	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000448620
...PDNNAL	164	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155181
...PDNNAL	164	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155182
...PSSVR	180	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PSSVR	180	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79136
...PSSVR	180	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79135

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)