TopFIND 4.0

Q9QW30: Neurogenic locus notch homolog protein 2 {ECO:0000250|UniProtKB:Q04721}

General Information

Protein names
- Neurogenic locus notch homolog protein 2 {ECO:0000250|UniProtKB:Q04721}
- Notch 2
- Notch 2 extracellular truncation
- Notch 2 intracellular domain
Gene names Notch2
Organism Rattus norvegicus
Protease Family
Protease ID
Chromosome location
UniProt ID Q9QW30

3

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MPALRPAALR ALLWLWLCGA GPAHALQCRG GQEPCVNEGT CVTYHNGTGY CRCPEGFLGE 
        70         80         90        100        110        120 
YCQHRDPCEK NRCQNGGTCV TQAMLGKATC RCAPGFTGED CQYSTSHPCF VSRPCQNGGT 
       130        140        150        160        170        180 
CHMLSWDTYE CTCQVGFTGK QCQWTDVCLS HPCENGSTCS SVANQFSCRC PAGITGQKCD 
       190        200        210        220        230        240 
ADINECDIPG RCQHGGTCLN LPGSYRCQCP QRFTGQHCDS PYVPCAPSPC VNGGTCRQTG 
       250        260        270        280        290        300 
DFTSECHCLP GFEGSNCERN IDDCPNHKCQ NGGVCVDGVN TYNCRCPPQW TGQFCTEDVD 
       310        320        330        340        350        360 
ECLLQPNACQ NGGTCTNRNG GYGCVCVNGW SGDDCSENID DCAFASCTPG STCIDRVASF 
       370        380        390        400        410        420 
SCLCPEGKAG LLCHLDDACI SNPCHKGALC DTNPLNGQYI CTCPQAYKGA DCTEDVDECA 
       430        440        450        460        470        480 
MANSNPCEHA GKCVNTDGAF HCECLKGYAG PRCEMDINEC HSDPCQNDAT CLDKIGGFTC 
       490        500        510        520        530        540 
LCMPGFKGVH CELEVNECQS NPCVNNGQCV DKVNRFQCLC PPGFTGPVCQ IDIDDCSSTP 
       550        560        570        580        590        600 
CLNGAKCIDH PNGYECQCAT GFTGTLCDEN IDNCDPDPCH HGQCQDGIDS YTCICNPGYM 
       610        620        630        640        650        660 
GAICSDQIDE CYSSPCLNDG RCIDLVNGYQ CNCQPGTSGL NCEINFDDCA SNPCLHGACV 
       670        680        690        700        710        720 
DGINRYSCVC SPGFTGQRCN IDIDECASNP CRKDATCIND VNGFRCMCPE GPHHPSCYSQ 
       730        740        750        760        770        780 
VNECLSSPCI HGNCTGGLSG YKCLCDAGWV GINCEVDKNE CLSNPCQNGG TCNNLVNGYR 
       790        800        810        820        830        840 
CTCKKGFKGY NCQVNIDECA SNPCLNQGTC LDDVSGYTCH CMLPYTGKNC QTVLAPCSPN 
       850        860        870        880        890        900 
PCENAAVCKE APNFESFTCL CAPGWQGQRC TVDVDECVSK PCMNNGICHN TQGSYMCECP 
       910        920        930        940        950        960 
PGFSGMDCEE DINDCLANPC QNGGSCVDKV NTFSCLCLPG FVGDKCQTDM NECLSEPCKN 
       970        980        990       1000       1010       1020 
GGTCSDYVNS YTCTCPAGFH GVHCENNIDE CTESSCFNGG TCVDGINSFS CLCPVGFTGP 
      1030       1040       1050       1060       1070       1080 
FCLHDINECS SNPCLNSGTC VDGLGTYRCT CPLGYTGKNC QTLVNLCSPS PCKNKGTCAQ 
      1090       1100       1110       1120       1130       1140 
EKARPRCLCP PGWDGAYCDV LNVSCKAAAL QKGVPVEHLC QHSGICINAG NTHHCQCPLG 
      1150       1160       1170       1180       1190       1200 
YTGSYCEEQL DECASNPCQH GATCSDFIGG YRCECVPGYQ GVNCEYEVDE CQNQPCQNGG 
      1210       1220       1230       1240       1250       1260 
TCIDLVNHFK CSCPPGTRGL LCEENIDDCA GAPHCLNGGQ CVDRIGGYSC RCLPGFAGER 
      1270       1280       1290       1300       1310       1320 
CEGDINECLS NPCSSEGSLD CIQLKNNYQC VCRSAFTGRH CETFLDVCPQ KPCLNGGTCA 
      1330       1340       1350       1360       1370       1380 
VASNVPDGFI CRCPPGFSGA RCQSSCGQVK CRRGEQCVHT ASGPHCFCPN HKDCESGCAS 
      1390       1400       1410       1420       1430       1440 
NPCQHGGTCY PQRQPPYYSC RCSPPFWGSH CESYTAPTST PPATCLSQYC ADKARDGICD 
      1450       1460       1470       1480       1490       1500 
EACNSHACQW DGGDCSLTME DPWANCTSSL RCWEYINNQC DELCNTAECL FDNFECQRNS 
      1510       1520       1530       1540       1550       1560 
KTCKYDKYCA DHFKDNHCDK GCNNEECGWD GLDCAADQPE NLAEGILVIV VLLPPEQLLQ 
      1570       1580       1590       1600       1610       1620 
DSRSFLRALG TLLHTNLRIK QDSQGALMVY PYYGEKSAAM KKQKVARRSL PDEQEQEIIG 
      1630       1640       1650       1660       1670       1680 
SKVFLEIDNR QCVQDSDQCF KNTDAAAALL ASHAIQGTLS YPLVSVVSES EDPRNTPLLY 
      1690       1700       1710       1720       1730       1740 
LLAVAVVIIL FLILLGVIMA KRKRKHGFLW LPEGFTLRRD SSNHKRREPV GQDAVGLKNL 
      1750       1760       1770       1780       1790       1800 
SVQVSEANLI GSTTSEHWGD DEGPQPKKAK AEDDEALLSE DDPVDRRPWT QQHLEAADIR 
      1810       1820       1830       1840       1850       1860 
RTPSLALTPP QAEQEVDVLD VNVRGPDGCT PLMLASLRGG SSDLSDEDED AEDSSANIIT 
      1870       1880       1890       1900       1910       1920 
DLVYQGASLQ AQTDRTGEMA LHLAARYSRA DAAKRLLDAG ADANAQDNMG RCPLHAAVAA 
      1930       1940       1950       1960       1970       1980 
DAQGVFQILI RNRVTDLDAR MNDGTTPLIL AARLAVEGMV AELINCQADV NAVDDHGKSA 
      1990       2000       2010       2020       2030       2040 
LHWAAAVNNV EATLLLLKNG ANRDMQDNKE ETPLFLAARE GSYEAAKILL DHFANRDITD 
      2050       2060       2070       2080       2090       2100 
HMDRLPRDVA RDRMHHDIVR LLDEYNVTPS PPGTVLTSAL SPVLCGPNRS FLSLKHTPMG 
      2110       2120       2130       2140       2150       2160 
KKARRPNTKS TMPTSLPNLA KEAKDVKGSR RKKCLNEKVQ LSESSVTLSP VDSLESPHTY 
      2170       2180       2190       2200       2210       2220 
VSDATSSPMI TSPGILQASP TPLLAAAPAA PVHAQHALSF SNLHEMQPLR PGASTVLPSV 
      2230       2240       2250       2260       2270       2280 
SQLLSHHHIV PPGSGSAGSL GRLHSVPVPS DWMNRVEMSE TQYSEMFGMV LAPAEGTHPG 
      2290       2300       2310       2320       2330       2340 
MAAPQSRAPE GKPIPTQREP LPPIVTFQLI PKGSLAQAAG APQTQSGCPP AVAGPLPSMY 
      2350       2360       2370       2380       2390       2400 
QIPEMARLPS VAFPPTMMPQ QEGQVAQTIV PTYHPFPASV GKYPTPPSQH SYASSNAAER 
      2410       2420       2430       2440       2450       2460 
TPNHGGHLQG EHPYLTPSPE SPDQWSSSSP HSASDWSDVT TSPTPGGGGG GQRGPGTHMS 
      2470    
EPPHSNMQVY A

Isoforms



Sequence View



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


Database:


Lab:



Protein Neighborhood

Domains & Features

3 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q9QW30-26-unknown LQCRGG... 26 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q9QW30-1666-unknown VVSESE... 1666 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q9QW30-1697-unknown VIMAKR... 1697 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...MQVYA 2471 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)