TopFIND 4.0

Q9UBZ4: DNA-(apurinic or apyrimidinic site) lyase 2

General Information

Protein names
- DNA-(apurinic or apyrimidinic site) lyase 2
- 3.1.-.-
- 4.2.99.18
- AP endonuclease XTH2
- APEX nuclease 2
- APEX nuclease-like 2
- Apurinic-apyrimidinic endonuclease 2
- AP endonuclease 2
Gene names APEX2
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q9UBZ4

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MLRVVSWNIN GIRRPLQGVA NQEPSNCAAV AVGRILDELD ADIVCLQETK VTRDALTEPL 
        70         80         90        100        110        120 
AIVEGYNSYF SFSRNRSGYS GVATFCKDNA TPVAAEEGLS GLFATQNGDV GCYGNMDEFT 
       130        140        150        160        170        180 
QEELRALDSE GRALLTQHKI RTWEGKEKTL TLINVYCPHA DPGRPERLVF KMRFYRLLQI 
       190        200        210        220        230        240 
RAEALLAAGS HVIILGDLNT AHRPIDHWDA VNLECFEEDP GRKWMDSLLS NLGCQSASHV 
       250        260        270        280        290        300 
GPFIDSYRCF QPKQEGAFTC WSAVTGARHL NYGSRLDYVL GDRTLVIDTF QASFLLPEVM 
       310        320        330        340        350        360 
GSDHCPVGAV LSVSSVPAKQ CPPLCTRFLP EFAGTQLKIL RFLVPLEQSP VLEQSTLQHN 
       370        380        390        400        410        420 
NQTRVQTCQN KAQVRSTRPQ PSQVGSSRGQ KNLKSYFQPS PSCPQASPDI ELPSLPLMSA 
       430        440        450        460        470        480 
LMTPKTPEEK AVAKVVKGQA KTSEAKDEKE LRTSFWKSVL AGPLRTPLCG GHREPCVMRT 
       490        500        510    
VKKPGPNLGR RFYMCARPRG PPTDPSSRCN FFLWSRPS

Isoforms



Sequence View



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Physiological Relevance:


Evidence Codes:


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Protease Assignment Confidence:


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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...WSRPS 518 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)