TopFIND 4.0

Q9UGN5: Poly [ADP-ribose] polymerase 2

General Information

Protein names
- Poly ADP-ribose] polymerase 2
- PARP-2
- hPARP-2
- 2.4.2.30 {ECO:0000269|PubMed:25043379}
- ADP-ribosyltransferase diphtheria toxin-like 2
- ARTD2
- DNA ADP-ribosyltransferase PARP2 {ECO:0000305}
- 2.4.2.- {ECO:0000269|PubMed:27471034}
- NAD(+) ADP-ribosyltransferase 2
- ADPRT-2
- PolyADP-ribose] synthase 2
- pADPRT-2
- Protein poly-ADP-ribosyltransferase PARP2 {ECO:0000305}
- 2.4.2.- {ECO:0000269|PubMed:25043379}
Gene names PARP2
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q9UGN5

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MAARRRRSTG GGRARALNES KRVNNGNTAP EDSSPAKKTR RCQRQESKKM PVAGGKANKD 
        70         80         90        100        110        120 
RTEDKQDGMP GRSWASKRVS ESVKALLLKG KAPVDPECTA KVGKAHVYCE GNDVYDVMLN 
       130        140        150        160        170        180 
QTNLQFNNNK YYLIQLLEDD AQRNFSVWMR WGRVGKMGQH SLVACSGNLN KAKEIFQKKF 
       190        200        210        220        230        240 
LDKTKNNWED REKFEKVPGK YDMLQMDYAT NTQDEEETKK EESLKSPLKP ESQLDLRVQE 
       250        260        270        280        290        300 
LIKLICNVQA MEEMMMEMKY NTKKAPLGKL TVAQIKAGYQ SLKKIEDCIR AGQHGRALME 
       310        320        330        340        350        360 
ACNEFYTRIP HDFGLRTPPL IRTQKELSEK IQLLEALGDI EIAIKLVKTE LQSPEHPLDQ 
       370        380        390        400        410        420 
HYRNLHCALR PLDHESYEFK VISQYLQSTH APTHSDYTMT LLDLFEVEKD GEKEAFREDL 
       430        440        450        460        470        480 
HNRMLLWHGS RMSNWVGILS HGLRIAPPEA PITGYMFGKG IYFADMSSKS ANYCFASRLK 
       490        500        510        520        530        540 
NTGLLLLSEV ALGQCNELLE ANPKAEGLLQ GKHSTKGLGK MAPSSAHFVT LNGSTVPLGP 
       550        560        570        580    
ASDTGILNPD GYTLNYNEYI VYNPNQVRMR YLLKVQFNFL QLW

Isoforms

- Isoform 2 of Poly [ADP-ribose] polymerase 2

Sequence View

        10         20         30         40         50         60 
MAARRRRSTG GGRARALNES KRVNNGNTAP EDSSPAKKTR RCQRQESKKM PVAGGKANKD 
        70         80         90        100        110        120 
RTEDKQDGMP GRSWASKRVS ESVKALLLKG KAPVDPECTA KVGKAHVYCE GNDVYDVMLN 
       130        140        150        160        170        180 
QTNLQFNNNK YYLIQLLEDD AQRNFSVWMR WGRVGKMGQH SLVACSGNLN KAKEIFQKKF 
       190        200        210        220        230        240 
LDKTKNNWED REKFEKVPGK YDMLQMDYAT NTQDEEETKK EESLKSPLKP ESQLDLRVQE 
       250        260        270        280        290        300 
LIKLICNVQA MEEMMMEMKY NTKKAPLGKL TVAQIKAGYQ SLKKIEDCIR AGQHGRALME 
       310        320        330        340        350        360 
ACNEFYTRIP HDFGLRTPPL IRTQKELSEK IQLLEALGDI EIAIKLVKTE LQSPEHPLDQ 
       370        380        390        400        410        420 
HYRNLHCALR PLDHESYEFK VISQYLQSTH APTHSDYTMT LLDLFEVEKD GEKEAFREDL 
       430        440        450        460        470        480 
HNRMLLWHGS RMSNWVGILS HGLRIAPPEA PITGYMFGKG IYFADMSSKS ANYCFASRLK 
       490        500        510        520        530        540 
NTGLLLLSEV ALGQCNELLE ANPKAEGLLQ GKHSTKGLGK MAPSSAHFVT LNGSTVPLGP 
       550        560        570        580    
ASDTGILNPD GYTLNYNEYI VYNPNQVRMR YLLKVQFNFL QLW



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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q9UGN5-1-unknown MAARRR... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q9UGN5-1-unknown MAARRR... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt84324

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...FLQLW 583 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...FLQLW 583 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt79942

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)