Q9UGP5: DNA polymerase lambda {ECO:0000305}

General Information

Protein names	- DNA polymerase lambda {ECO:0000305} - Pol Lambda {ECO:0000305} - 2.7.7.7 {ECO:0000269\|PubMed:10887191, ECO:0000269\|PubMed:10982892, ECO:0000269\|PubMed:12809503, ECO:0000269\|PubMed:14627824, ECO:0000269\|PubMed:15537631, ECO:0000269\|PubMed:19806195} - 4.2.99.- {ECO:0000269\|PubMed:11457865, ECO:0000269\|PubMed:19806195} - DNA polymerase beta-2 {ECO:0000303\|PubMed:10887191} - Pol beta2 {ECO:0000303\|PubMed:10887191} - DNA polymerase kappa {ECO:0000303\|Ref.1}
Gene names	POLL
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9UGP5

2 N-termini

6 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MDPRGILKAF PKRQKIHADA SSKVLAKIPR REEGEEAEEW LSSLRAHVVR TGIGRARAEL
        70         80         90        100        110        120
FEKQIVQHGG QLCPAQGPGV THIVVDEGMD YERALRLLRL PQLPPGAQLV KSAWLSLCLQ
       130        140        150        160        170        180
ERRLVDVAGF SIFIPSRYLD HPQPSKAEQD ASIPPGTHEA LLQTALSPPP PPTRPVSPPQ
       190        200        210        220        230        240
KAKEAPNTQA QPISDDEASD GEETQVSAAD LEALISGHYP TSLEGDCEPS PAPAVLDKWV
       250        260        270        280        290        300
CAQPSSQKAT NHNLHITEKL EVLAKAYSVQ GDKWRALGYA KAINALKSFH KPVTSYQEAC
       310        320        330        340        350        360
SIPGIGKRMA EKIIEILESG HLRKLDHISE SVPVLELFSN IWGAGTKTAQ MWYQQGFRSL
       370        380        390        400        410        420
EDIRSQASLT TQQAIGLKHY SDFLERMPRE EATEIEQTVQ KAAQAFNSGL LCVACGSYRR
       430        440        450        460        470        480
GKATCGDVDV LITHPDGRSH RGIFSRLLDS LRQEGFLTDD LVSQEENGQQ QKYLGVCRLP
       490        500        510        520        530        540
GPGRRHRRLD IIVVPYSEFA CALLYFTGSA HFNRSMRALA KTKGMSLSEH ALSTAVVRNT
       550        560        570
HGCKVGPGRV LPTPTEKDVF RLLGLPYREP AERDW

Isoforms

- Isoform 2 of DNA polymerase lambda

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

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Protein Neighborhood

Domains & Features

2 N-termini - 6 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9UGP5-1-unknown	MDPRGI...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9UGP5-89-unknown	MDYERA...	89	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000359191
Q9UGP5-89-unknown	MDYERA...	89	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000390093
Q9UGP5-89-unknown	MDYERA...	89	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000405331

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EAPNTQ	188	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000414293
...AKAYSV	268	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000400517
...SGHLRK	323	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000411678
...IIVVPY	495	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000406791
...LPTPTE	555	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000400676
...AERDW	575	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)