Q9UHD2: Serine/threonine-protein kinase TBK1 {ECO:0000305}

General Information

Protein names	- Serine/threonine-protein kinase TBK1 {ECO:0000305} - 2.7.11.1 {ECO:0000269\|PubMed:15367631, ECO:0000269\|PubMed:18583960, ECO:0000269\|PubMed:21138416, ECO:0000269\|PubMed:21270402, ECO:0000269\|PubMed:21464307, ECO:0000269\|PubMed:21617041, ECO:0000269\|PubMed:25636800} - NF-kappa-B-activating kinase {ECO:0000303\|PubMed:10783893} - T2K - TANK-binding kinase 1 {ECO:0000303\|PubMed:10581243}
Gene names	TBK1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9UHD2

2 N-termini

4 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MQSTSNHLWL LSDILGQGAT ANVFRGRHKK TGDLFAIKVF NNISFLRPVD VQMREFEVLK
        70         80         90        100        110        120
KLNHKNIVKL FAIEEETTTR HKVLIMEFCP CGSLYTVLEE PSNAYGLPES EFLIVLRDVV
       130        140        150        160        170        180
GGMNHLRENG IVHRDIKPGN IMRVIGEDGQ SVYKLTDFGA ARELEDDEQF VSLYGTEEYL
       190        200        210        220        230        240
HPDMYERAVL RKDHQKKYGA TVDLWSIGVT FYHAATGSLP FRPFEGPRRN KEVMYKIITG
       250        260        270        280        290        300
KPSGAISGVQ KAENGPIDWS GDMPVSCSLS RGLQVLLTPV LANILEADQE KCWGFDQFFA
       310        320        330        340        350        360
ETSDILHRMV IHVFSLQQMT AHKIYIHSYN TATIFHELVY KQTKIISSNQ ELIYEGRRLV
       370        380        390        400        410        420
LEPGRLAQHF PKTTEENPIF VVSREPLNTI GLIYEKISLP KVHPRYDLDG DASMAKAITG
       430        440        450        460        470        480
VVCYACRIAS TLLLYQELMR KGIRWLIELI KDDYNETVHK KTEVVITLDF CIRNIEKTVK
       490        500        510        520        530        540
VYEKLMKINL EAAELGEISD IHTKLLRLSS SQGTIETSLQ DIDSRLSPGG SLADAWAHQE
       550        560        570        580        590        600
GTHPKDRNVE KLQVLLNCMT EIYYQFKKDK AERRLAYNEE QIHKFDKQKL YYHATKAMTH
       610        620        630        640        650        660
FTDECVKKYE AFLNKSEEWI RKMLHLRKQL LSLTNQCFDI EEEVSKYQEY TNELQETLPQ
       670        680        690        700        710        720
KMFTASSGIK HTMTPIYPSS NTLVEMTLGM KKLKEEMEGV VKELAENNHI LERFGSLTMD

GGLRNVDCL

Isoforms

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

2 N-termini - 4 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9UHD2-1-unknown	MQSTSN...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9UHD2-53-unknown	MREFEV...	53		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000444428

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LYTVLE	98	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000445628
...TVLEEP	100	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000444428
...EEPSNA	103	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000445834
...NVDCL	729	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)