Q9UIS9: Methyl-CpG-binding domain protein 1

General Information

Protein names	- Methyl-CpG-binding domain protein 1 - CXXC-type zinc finger protein 3 - Methyl-CpG-binding protein MBD1 - Protein containing methyl-CpG-binding domain 1
Gene names	MBD1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9UIS9

2 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Methyl-CpG-binding domain protein 1 - Isoform 4 of Methyl-CpG-binding domain protein 1 - Isoform 5 of Methyl-CpG-binding domain protein 1 - Isoform 6 of Methyl-CpG-binding domain protein 1 - Isoform 7 of Methyl-CpG-binding domain protein 1 - Isoform 8 of Methyl-CpG-binding domain protein 1 - Isoform 9 of Methyl-CpG-binding domain protein 1 - Isoform 10 of Methyl-CpG-binding domain protein 1 - Isoform 11 of Methyl-CpG-binding domain protein 1 - Isoform 12 of Methyl-CpG-binding domain protein 1

Sequence View

        10         20         30         40         50         60
MAEDWLDCPA LGPGWKRREV FRKSGATCGR SDTYYQSPTG DRIRSKVELT RYLGPACDLT
        70         80         90        100        110        120
LFDFKQGILC YPAPKAHPVA VASKKRKKPS RPAKTRKRQV GPQSGEVRKE APRDETKADT
       130        140        150        160        170        180
DTAPASFPAP GCCENCGISF SGDGTQRQRL KTLCKDCRAQ RIAFNREQRM FKRVGCGECA
       190        200        210        220        230        240
ACQVTEDCGA CSTCLLQLPH DVASGLFCKC ERRRCLRIVE RSRGCGVCRG CQTQEDCGHC
       250        260        270        280        290        300
PICLRPPRPG LRRQWKCVQR RCLRGKHARR KGGCDSKMAA RRRPGAQPLP PPPPSQSPEP
       310        320        330        340        350        360
TEPHPRALAP SPPAEFIYYC VDEDELQPYT NRRQNRKCGA CAACLRRMDC GRCDFCCDKP
       370        380        390        400        410        420
KFGGSNQKRQ KCRWRQCLQF AMKRLLPSVW SESEDGAGSP PPYRRRKRPS SARRHHLGPT
       430        440        450        460        470        480
LKPTLATRTA QPDHTQAPTK QEAGGGFVLP PPGTDLVFLR EGASSPVQVP GPVAASTEAL
       490        500        510        520        530        540
LQEAQCSGLS WVVALPQVKQ EKADTQDEWT PGTAVLTSPV LVPGCPSKAV DPGLPSVKQE
       550        560        570        580        590        600
PPDPEEDKEE NKDDSASKLA PEEEAGGAGT PVITEIFSLG GTRFRDTAVW LPRSKDLKKP

GARKQ         10         20         30         40         50         60
MAEDWLDCPA LGPGWKRREV FRKSGATCGR SDTYYQSPTG DRIRSKVELT RYLGPACDLT
        70         80         90        100        110        120
LFDFKQGILC YPAPKAHPVA VASKKRKKPS RPAKTRKRQV GPQSGEVRKE APRDETKADT
       130        140        150        160        170        180
DTAPASFPAP GCCENCGISF SGDGTQRQRL KTLCKDCRAQ RIAFNREQRM FKRVGCGECA
       190        200        210        220        230        240
ACQVTEDCGA CSTCLLQLPH DVASGLFCKC ERRRCLRIVE RSRGCGVCRG CQTQEDCGHC
       250        260        270        280        290        300
PICLRPPRPG LRRQWKCVQR RCLRGKHARR KGGCDSKMAA RRRPGAQPLP PPPPSQSPEP
       310        320        330        340        350        360
TEPHPRALAP SPPAEFIYYC VDEDELQPYT NRRQNRKCGA CAACLRRMDC GRCDFCCDKP
       370        380        390        400        410        420
KFGGSNQKRQ KCRWRQCLQF AMKRLLPSVW SESEDGAGSP PPYRRRKRPS SARRHHLGPT
       430        440        450        460        470        480
LKPTLATRTA QPDHTQAPTK QEAGGGFVLP PPGTDLVFLR EGASSPVQVP GPVAASTEAL
       490        500        510        520        530        540
LQEAQCSGLS WVVALPQVKQ EKADTQDEWT PGTAVLTSPV LVPGCPSKAV DPGLPSVKQE
       550        560        570        580        590        600
PPDPEEDKEE NKDDSASKLA PEEEAGGAGT PVITEIFSLG GTRFRDTAVW LPRSKDLKKP

GARKQ         10         20         30         40         50         60
MAEDWLDCPA LGPGWKRREV FRKSGATCGR SDTYYQSPTG DRIRSKVELT RYLGPACDLT
        70         80         90        100        110        120
LFDFKQGILC YPAPKAHPVA VASKKRKKPS RPAKTRKRQV GPQSGEVRKE APRDETKADT
       130        140        150        160        170        180
DTAPASFPAP GCCENCGISF SGDGTQRQRL KTLCKDCRAQ RIAFNREQRM FKRVGCGECA
       190        200        210        220        230        240
ACQVTEDCGA CSTCLLQLPH DVASGLFCKC ERRRCLRIVE RSRGCGVCRG CQTQEDCGHC
       250        260        270        280        290        300
PICLRPPRPG LRRQWKCVQR RCLRGKHARR KGGCDSKMAA RRRPGAQPLP PPPPSQSPEP
       310        320        330        340        350        360
TEPHPRALAP SPPAEFIYYC VDEDELQPYT NRRQNRKCGA CAACLRRMDC GRCDFCCDKP
       370        380        390        400        410        420
KFGGSNQKRQ KCRWRQCLQF AMKRLLPSVW SESEDGAGSP PPYRRRKRPS SARRHHLGPT
       430        440        450        460        470        480
LKPTLATRTA QPDHTQAPTK QEAGGGFVLP PPGTDLVFLR EGASSPVQVP GPVAASTEAL
       490        500        510        520        530        540
LQEAQCSGLS WVVALPQVKQ EKADTQDEWT PGTAVLTSPV LVPGCPSKAV DPGLPSVKQE
       550        560        570        580        590        600
PPDPEEDKEE NKDDSASKLA PEEEAGGAGT PVITEIFSLG GTRFRDTAVW LPRSKDLKKP

GARKQ         10         20         30         40         50         60
MAEDWLDCPA LGPGWKRREV FRKSGATCGR SDTYYQSPTG DRIRSKVELT RYLGPACDLT
        70         80         90        100        110        120
LFDFKQGILC YPAPKAHPVA VASKKRKKPS RPAKTRKRQV GPQSGEVRKE APRDETKADT
       130        140        150        160        170        180
DTAPASFPAP GCCENCGISF SGDGTQRQRL KTLCKDCRAQ RIAFNREQRM FKRVGCGECA
       190        200        210        220        230        240
ACQVTEDCGA CSTCLLQLPH DVASGLFCKC ERRRCLRIVE RSRGCGVCRG CQTQEDCGHC
       250        260        270        280        290        300
PICLRPPRPG LRRQWKCVQR RCLRGKHARR KGGCDSKMAA RRRPGAQPLP PPPPSQSPEP
       310        320        330        340        350        360
TEPHPRALAP SPPAEFIYYC VDEDELQPYT NRRQNRKCGA CAACLRRMDC GRCDFCCDKP
       370        380        390        400        410        420
KFGGSNQKRQ KCRWRQCLQF AMKRLLPSVW SESEDGAGSP PPYRRRKRPS SARRHHLGPT
       430        440        450        460        470        480
LKPTLATRTA QPDHTQAPTK QEAGGGFVLP PPGTDLVFLR EGASSPVQVP GPVAASTEAL
       490        500        510        520        530        540
LQEAQCSGLS WVVALPQVKQ EKADTQDEWT PGTAVLTSPV LVPGCPSKAV DPGLPSVKQE
       550        560        570        580        590        600
PPDPEEDKEE NKDDSASKLA PEEEAGGAGT PVITEIFSLG GTRFRDTAVW LPRSKDLKKP

GARKQ         10         20         30         40         50         60
MAEDWLDCPA LGPGWKRREV FRKSGATCGR SDTYYQSPTG DRIRSKVELT RYLGPACDLT
        70         80         90        100        110        120
LFDFKQGILC YPAPKAHPVA VASKKRKKPS RPAKTRKRQV GPQSGEVRKE APRDETKADT
       130        140        150        160        170        180
DTAPASFPAP GCCENCGISF SGDGTQRQRL KTLCKDCRAQ RIAFNREQRM FKRVGCGECA
       190        200        210        220        230        240
ACQVTEDCGA CSTCLLQLPH DVASGLFCKC ERRRCLRIVE RSRGCGVCRG CQTQEDCGHC
       250        260        270        280        290        300
PICLRPPRPG LRRQWKCVQR RCLRGKHARR KGGCDSKMAA RRRPGAQPLP PPPPSQSPEP
       310        320        330        340        350        360
TEPHPRALAP SPPAEFIYYC VDEDELQPYT NRRQNRKCGA CAACLRRMDC GRCDFCCDKP
       370        380        390        400        410        420
KFGGSNQKRQ KCRWRQCLQF AMKRLLPSVW SESEDGAGSP PPYRRRKRPS SARRHHLGPT
       430        440        450        460        470        480
LKPTLATRTA QPDHTQAPTK QEAGGGFVLP PPGTDLVFLR EGASSPVQVP GPVAASTEAL
       490        500        510        520        530        540
LQEAQCSGLS WVVALPQVKQ EKADTQDEWT PGTAVLTSPV LVPGCPSKAV DPGLPSVKQE
       550        560        570        580        590        600
PPDPEEDKEE NKDDSASKLA PEEEAGGAGT PVITEIFSLG GTRFRDTAVW LPRSKDLKKP

GARKQ         10         20         30         40         50         60
MAEDWLDCPA LGPGWKRREV FRKSGATCGR SDTYYQSPTG DRIRSKVELT RYLGPACDLT
        70         80         90        100        110        120
LFDFKQGILC YPAPKAHPVA VASKKRKKPS RPAKTRKRQV GPQSGEVRKE APRDETKADT
       130        140        150        160        170        180
DTAPASFPAP GCCENCGISF SGDGTQRQRL KTLCKDCRAQ RIAFNREQRM FKRVGCGECA
       190        200        210        220        230        240
ACQVTEDCGA CSTCLLQLPH DVASGLFCKC ERRRCLRIVE RSRGCGVCRG CQTQEDCGHC
       250        260        270        280        290        300
PICLRPPRPG LRRQWKCVQR RCLRGKHARR KGGCDSKMAA RRRPGAQPLP PPPPSQSPEP
       310        320        330        340        350        360
TEPHPRALAP SPPAEFIYYC VDEDELQPYT NRRQNRKCGA CAACLRRMDC GRCDFCCDKP
       370        380        390        400        410        420
KFGGSNQKRQ KCRWRQCLQF AMKRLLPSVW SESEDGAGSP PPYRRRKRPS SARRHHLGPT
       430        440        450        460        470        480
LKPTLATRTA QPDHTQAPTK QEAGGGFVLP PPGTDLVFLR EGASSPVQVP GPVAASTEAL
       490        500        510        520        530        540
LQEAQCSGLS WVVALPQVKQ EKADTQDEWT PGTAVLTSPV LVPGCPSKAV DPGLPSVKQE
       550        560        570        580        590        600
PPDPEEDKEE NKDDSASKLA PEEEAGGAGT PVITEIFSLG GTRFRDTAVW LPRSKDLKKP

GARKQ         10         20         30         40         50         60
MAEDWLDCPA LGPGWKRREV FRKSGATCGR SDTYYQSPTG DRIRSKVELT RYLGPACDLT
        70         80         90        100        110        120
LFDFKQGILC YPAPKAHPVA VASKKRKKPS RPAKTRKRQV GPQSGEVRKE APRDETKADT
       130        140        150        160        170        180
DTAPASFPAP GCCENCGISF SGDGTQRQRL KTLCKDCRAQ RIAFNREQRM FKRVGCGECA
       190        200        210        220        230        240
ACQVTEDCGA CSTCLLQLPH DVASGLFCKC ERRRCLRIVE RSRGCGVCRG CQTQEDCGHC
       250        260        270        280        290        300
PICLRPPRPG LRRQWKCVQR RCLRGKHARR KGGCDSKMAA RRRPGAQPLP PPPPSQSPEP
       310        320        330        340        350        360
TEPHPRALAP SPPAEFIYYC VDEDELQPYT NRRQNRKCGA CAACLRRMDC GRCDFCCDKP
       370        380        390        400        410        420
KFGGSNQKRQ KCRWRQCLQF AMKRLLPSVW SESEDGAGSP PPYRRRKRPS SARRHHLGPT
       430        440        450        460        470        480
LKPTLATRTA QPDHTQAPTK QEAGGGFVLP PPGTDLVFLR EGASSPVQVP GPVAASTEAL
       490        500        510        520        530        540
LQEAQCSGLS WVVALPQVKQ EKADTQDEWT PGTAVLTSPV LVPGCPSKAV DPGLPSVKQE
       550        560        570        580        590        600
PPDPEEDKEE NKDDSASKLA PEEEAGGAGT PVITEIFSLG GTRFRDTAVW LPRSKDLKKP

GARKQ         10         20         30         40         50         60
MAEDWLDCPA LGPGWKRREV FRKSGATCGR SDTYYQSPTG DRIRSKVELT RYLGPACDLT
        70         80         90        100        110        120
LFDFKQGILC YPAPKAHPVA VASKKRKKPS RPAKTRKRQV GPQSGEVRKE APRDETKADT
       130        140        150        160        170        180
DTAPASFPAP GCCENCGISF SGDGTQRQRL KTLCKDCRAQ RIAFNREQRM FKRVGCGECA
       190        200        210        220        230        240
ACQVTEDCGA CSTCLLQLPH DVASGLFCKC ERRRCLRIVE RSRGCGVCRG CQTQEDCGHC
       250        260        270        280        290        300
PICLRPPRPG LRRQWKCVQR RCLRGKHARR KGGCDSKMAA RRRPGAQPLP PPPPSQSPEP
       310        320        330        340        350        360
TEPHPRALAP SPPAEFIYYC VDEDELQPYT NRRQNRKCGA CAACLRRMDC GRCDFCCDKP
       370        380        390        400        410        420
KFGGSNQKRQ KCRWRQCLQF AMKRLLPSVW SESEDGAGSP PPYRRRKRPS SARRHHLGPT
       430        440        450        460        470        480
LKPTLATRTA QPDHTQAPTK QEAGGGFVLP PPGTDLVFLR EGASSPVQVP GPVAASTEAL
       490        500        510        520        530        540
LQEAQCSGLS WVVALPQVKQ EKADTQDEWT PGTAVLTSPV LVPGCPSKAV DPGLPSVKQE
       550        560        570        580        590        600
PPDPEEDKEE NKDDSASKLA PEEEAGGAGT PVITEIFSLG GTRFRDTAVW LPRSKDLKKP

GARKQ         10         20         30         40         50         60
MAEDWLDCPA LGPGWKRREV FRKSGATCGR SDTYYQSPTG DRIRSKVELT RYLGPACDLT
        70         80         90        100        110        120
LFDFKQGILC YPAPKAHPVA VASKKRKKPS RPAKTRKRQV GPQSGEVRKE APRDETKADT
       130        140        150        160        170        180
DTAPASFPAP GCCENCGISF SGDGTQRQRL KTLCKDCRAQ RIAFNREQRM FKRVGCGECA
       190        200        210        220        230        240
ACQVTEDCGA CSTCLLQLPH DVASGLFCKC ERRRCLRIVE RSRGCGVCRG CQTQEDCGHC
       250        260        270        280        290        300
PICLRPPRPG LRRQWKCVQR RCLRGKHARR KGGCDSKMAA RRRPGAQPLP PPPPSQSPEP
       310        320        330        340        350        360
TEPHPRALAP SPPAEFIYYC VDEDELQPYT NRRQNRKCGA CAACLRRMDC GRCDFCCDKP
       370        380        390        400        410        420
KFGGSNQKRQ KCRWRQCLQF AMKRLLPSVW SESEDGAGSP PPYRRRKRPS SARRHHLGPT
       430        440        450        460        470        480
LKPTLATRTA QPDHTQAPTK QEAGGGFVLP PPGTDLVFLR EGASSPVQVP GPVAASTEAL
       490        500        510        520        530        540
LQEAQCSGLS WVVALPQVKQ EKADTQDEWT PGTAVLTSPV LVPGCPSKAV DPGLPSVKQE
       550        560        570        580        590        600
PPDPEEDKEE NKDDSASKLA PEEEAGGAGT PVITEIFSLG GTRFRDTAVW LPRSKDLKKP

GARKQ         10         20         30         40         50         60
MAEDWLDCPA LGPGWKRREV FRKSGATCGR SDTYYQSPTG DRIRSKVELT RYLGPACDLT
        70         80         90        100        110        120
LFDFKQGILC YPAPKAHPVA VASKKRKKPS RPAKTRKRQV GPQSGEVRKE APRDETKADT
       130        140        150        160        170        180
DTAPASFPAP GCCENCGISF SGDGTQRQRL KTLCKDCRAQ RIAFNREQRM FKRVGCGECA
       190        200        210        220        230        240
ACQVTEDCGA CSTCLLQLPH DVASGLFCKC ERRRCLRIVE RSRGCGVCRG CQTQEDCGHC
       250        260        270        280        290        300
PICLRPPRPG LRRQWKCVQR RCLRGKHARR KGGCDSKMAA RRRPGAQPLP PPPPSQSPEP
       310        320        330        340        350        360
TEPHPRALAP SPPAEFIYYC VDEDELQPYT NRRQNRKCGA CAACLRRMDC GRCDFCCDKP
       370        380        390        400        410        420
KFGGSNQKRQ KCRWRQCLQF AMKRLLPSVW SESEDGAGSP PPYRRRKRPS SARRHHLGPT
       430        440        450        460        470        480
LKPTLATRTA QPDHTQAPTK QEAGGGFVLP PPGTDLVFLR EGASSPVQVP GPVAASTEAL
       490        500        510        520        530        540
LQEAQCSGLS WVVALPQVKQ EKADTQDEWT PGTAVLTSPV LVPGCPSKAV DPGLPSVKQE
       550        560        570        580        590        600
PPDPEEDKEE NKDDSASKLA PEEEAGGAGT PVITEIFSLG GTRFRDTAVW LPRSKDLKKP

GARKQ

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9UIS9-1-unknown	MAEDWL...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9UIS9-1-unknown	MAEDWL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80506
Q9UIS9-1-unknown	MAEDWL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80507
Q9UIS9-1-unknown	MAEDWL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80508
Q9UIS9-1-unknown	MAEDWL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80509
Q9UIS9-1-unknown	MAEDWL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80510
Q9UIS9-1-unknown	MAEDWL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80511
Q9UIS9-1-unknown	MAEDWL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80512
Q9UIS9-295-unknown	SQSPEP...	295	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000466806
Q9UIS9-295-unknown	SQSPEP...	295	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt198805
Q9UIS9-295-unknown	SQSPEP...	295	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt198803
Q9UIS9-295-unknown	SQSPEP...	295	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt198804
Q9UIS9-295-unknown	SQSPEP...	295	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt198806
Q9UIS9-295-unknown	SQSPEP...	295	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt198802

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ASSPVQ	467	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000466429
...GARKQ	605	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GARKQ	605	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76125
...GARKQ	605	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76129
...GARKQ	605	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76128
...GARKQ	605	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76126
...GARKQ	605	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76130

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)