Q9UJ41: Rab5 GDP/GTP exchange factor

General Information

Protein names	- Rab5 GDP/GTP exchange factor - RAP1 - Rabaptin-5-associated exchange factor for Rab5 - Rabex-5
Gene names	RABGEF1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9UJ41

2 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Rab5 GDP/GTP exchange factor - Isoform 3 of Rab5 GDP/GTP exchange factor - Isoform 4 of Rab5 GDP/GTP exchange factor - Isoform 2 of Rab5 GDP/GTP exchange factor - Isoform 3 of Rab5 GDP/GTP exchange factor

Sequence View

        10         20         30         40         50         60
MSLKSERRGI HVDQSDLLCK KGCGYYGNPA WQGFCSKCWR EEYHKARQKQ IQEDWELAER
        70         80         90        100        110        120
LQREEEEAFA SSQSSQGAQS LTFSKFEEKK TNEKTRKVTT VKKFFSASSR VGSKKEIQEA
       130        140        150        160        170        180
KAPSPSINRQ TSIETDRVSK EFIEFLKTFH KTGQEIYKQT KLFLEGMHYK RDLSIEEQSE
       190        200        210        220        230        240
CAQDFYHNVA ERMQTRGKVP PERVEKIMDQ IEKYIMTRLY KYVFCPETTD DEKKDLAIQK
       250        260        270        280        290        300
RIRALRWVTP QMLCVPVNED IPEVSDMVVK AITDIIEMDS KRVPRDKLAC ITKCSKHIFN
       310        320        330        340        350        360
AIKITKNEPA SADDFLPTLI YIVLKGNPPR LQSNIQYITR FCNPSRLMTG EDGYYFTNLC
       370        380        390        400        410        420
CAVAFIEKLD AQSLNLSQED FDRYMSGQTS PRKQEAESWS PDACLGVKQM YKNLDLLSQL
       430        440        450        460        470        480
NERQERIMNE AKKLEKDLID WTDGIAREVQ DIVEKYPLEI KPPNQPLAAI DSENVENDKL
       490
PPPLQPQVYA G         10         20         30         40         50         60
MSLKSERRGI HVDQSDLLCK KGCGYYGNPA WQGFCSKCWR EEYHKARQKQ IQEDWELAER
        70         80         90        100        110        120
LQREEEEAFA SSQSSQGAQS LTFSKFEEKK TNEKTRKVTT VKKFFSASSR VGSKKEIQEA
       130        140        150        160        170        180
KAPSPSINRQ TSIETDRVSK EFIEFLKTFH KTGQEIYKQT KLFLEGMHYK RDLSIEEQSE
       190        200        210        220        230        240
CAQDFYHNVA ERMQTRGKVP PERVEKIMDQ IEKYIMTRLY KYVFCPETTD DEKKDLAIQK
       250        260        270        280        290        300
RIRALRWVTP QMLCVPVNED IPEVSDMVVK AITDIIEMDS KRVPRDKLAC ITKCSKHIFN
       310        320        330        340        350        360
AIKITKNEPA SADDFLPTLI YIVLKGNPPR LQSNIQYITR FCNPSRLMTG EDGYYFTNLC
       370        380        390        400        410        420
CAVAFIEKLD AQSLNLSQED FDRYMSGQTS PRKQEAESWS PDACLGVKQM YKNLDLLSQL
       430        440        450        460        470        480
NERQERIMNE AKKLEKDLID WTDGIAREVQ DIVEKYPLEI KPPNQPLAAI DSENVENDKL
       490
PPPLQPQVYA G         10         20         30         40         50         60
MSLKSERRGI HVDQSDLLCK KGCGYYGNPA WQGFCSKCWR EEYHKARQKQ IQEDWELAER
        70         80         90        100        110        120
LQREEEEAFA SSQSSQGAQS LTFSKFEEKK TNEKTRKVTT VKKFFSASSR VGSKKEIQEA
       130        140        150        160        170        180
KAPSPSINRQ TSIETDRVSK EFIEFLKTFH KTGQEIYKQT KLFLEGMHYK RDLSIEEQSE
       190        200        210        220        230        240
CAQDFYHNVA ERMQTRGKVP PERVEKIMDQ IEKYIMTRLY KYVFCPETTD DEKKDLAIQK
       250        260        270        280        290        300
RIRALRWVTP QMLCVPVNED IPEVSDMVVK AITDIIEMDS KRVPRDKLAC ITKCSKHIFN
       310        320        330        340        350        360
AIKITKNEPA SADDFLPTLI YIVLKGNPPR LQSNIQYITR FCNPSRLMTG EDGYYFTNLC
       370        380        390        400        410        420
CAVAFIEKLD AQSLNLSQED FDRYMSGQTS PRKQEAESWS PDACLGVKQM YKNLDLLSQL
       430        440        450        460        470        480
NERQERIMNE AKKLEKDLID WTDGIAREVQ DIVEKYPLEI KPPNQPLAAI DSENVENDKL
       490
PPPLQPQVYA G         10         20         30         40         50         60
MSLKSERRGI HVDQSDLLCK KGCGYYGNPA WQGFCSKCWR EEYHKARQKQ IQEDWELAER
        70         80         90        100        110        120
LQREEEEAFA SSQSSQGAQS LTFSKFEEKK TNEKTRKVTT VKKFFSASSR VGSKKEIQEA
       130        140        150        160        170        180
KAPSPSINRQ TSIETDRVSK EFIEFLKTFH KTGQEIYKQT KLFLEGMHYK RDLSIEEQSE
       190        200        210        220        230        240
CAQDFYHNVA ERMQTRGKVP PERVEKIMDQ IEKYIMTRLY KYVFCPETTD DEKKDLAIQK
       250        260        270        280        290        300
RIRALRWVTP QMLCVPVNED IPEVSDMVVK AITDIIEMDS KRVPRDKLAC ITKCSKHIFN
       310        320        330        340        350        360
AIKITKNEPA SADDFLPTLI YIVLKGNPPR LQSNIQYITR FCNPSRLMTG EDGYYFTNLC
       370        380        390        400        410        420
CAVAFIEKLD AQSLNLSQED FDRYMSGQTS PRKQEAESWS PDACLGVKQM YKNLDLLSQL
       430        440        450        460        470        480
NERQERIMNE AKKLEKDLID WTDGIAREVQ DIVEKYPLEI KPPNQPLAAI DSENVENDKL
       490
PPPLQPQVYA G         10         20         30         40         50         60
MSLKSERRGI HVDQSDLLCK KGCGYYGNPA WQGFCSKCWR EEYHKARQKQ IQEDWELAER
        70         80         90        100        110        120
LQREEEEAFA SSQSSQGAQS LTFSKFEEKK TNEKTRKVTT VKKFFSASSR VGSKKEIQEA
       130        140        150        160        170        180
KAPSPSINRQ TSIETDRVSK EFIEFLKTFH KTGQEIYKQT KLFLEGMHYK RDLSIEEQSE
       190        200        210        220        230        240
CAQDFYHNVA ERMQTRGKVP PERVEKIMDQ IEKYIMTRLY KYVFCPETTD DEKKDLAIQK
       250        260        270        280        290        300
RIRALRWVTP QMLCVPVNED IPEVSDMVVK AITDIIEMDS KRVPRDKLAC ITKCSKHIFN
       310        320        330        340        350        360
AIKITKNEPA SADDFLPTLI YIVLKGNPPR LQSNIQYITR FCNPSRLMTG EDGYYFTNLC
       370        380        390        400        410        420
CAVAFIEKLD AQSLNLSQED FDRYMSGQTS PRKQEAESWS PDACLGVKQM YKNLDLLSQL
       430        440        450        460        470        480
NERQERIMNE AKKLEKDLID WTDGIAREVQ DIVEKYPLEI KPPNQPLAAI DSENVENDKL
       490
PPPLQPQVYA G

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9UJ41-1-unknown	MSLKSE...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9UJ41-1-unknown	MSLKSE...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt86877
Q9UJ41-1-unknown	MSLKSE...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt86878
Q9UJ41-1-unknown	MSLKSE...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt101189
Q9UJ41-139-unknown	SKEFIE...	139	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt86877
Q9UJ41-139-unknown	SKEFIE...	139	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt86878
Q9UJ41-139-unknown	SKEFIE...	139	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000415503
Q9UJ41-139-unknown	SKEFIE...	139	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000415815
Q9UJ41-139-unknown	SKEFIE...	139	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000284957
Q9UJ41-139-unknown	SKEFIE...	139	inferred from electronic annotation	unknown	TISdb	inferred from TISdb
Q9UJ41-139-unknown	SKEFIE...	139	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt101189

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SECAQD	183	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000415503
...SECAQD	183	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155422
...SECAQD	183	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155423
...SECAQD	183	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155421
...	708	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...	708	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt82495
...	708	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt82497
...	708	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt82496

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)