Q9UJ83: 2-hydroxyacyl-CoA lyase 1

General Information

Protein names	- 2-hydroxyacyl-CoA lyase 1 - 4.1.-.- - 2-hydroxyphytanoyl-CoA lyase - 2-HPCL - Phytanoyl-CoA 2-hydroxylase 2
Gene names	HACL1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9UJ83

2 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of 2-hydroxyacyl-CoA lyase 1 - Isoform 4 of 2-hydroxyacyl-CoA lyase 1 - Isoform 3 of 2-hydroxyacyl-CoA lyase 1

Sequence View

        10         20         30         40         50         60
MPDSNFAERS EEQVSGAKVI AQALKTQDVE YIFGIVGIPV TEIAIAAQQL GIKYIGMRNE
        70         80         90        100        110        120
QAACYAASAI GYLTSRPGVC LVVSGPGLIH ALGGMANANM NCWPLLVIGG SSERNQETMG
       130        140        150        160        170        180
AFQEFPQVEA CRLYTKFSAR PSSIEAIPFV IEKAVRSSIY GRPGACYVDI PADFVNLQVN
       190        200        210        220        230        240
VNSIKYMERC MSPPISMAET SAVCTAASVI RNAKQPLLII GKGAAYAHAE ESIKKLVEQY
       250        260        270        280        290        300
KLPFLPTPMG KGVVPDNHPY CVGAARSRAL QFADVIVLFG ARLNWILHFG LPPRYQPDVK
       310        320        330        340        350        360
FIQVDICAEE LGNNVKPAVT LLGNIHAVTK QLLEELDKTP WQYPPESKWW KTLREKMKSN
       370        380        390        400        410        420
EAASKELASK KSLPMNYYTV FYHVQEQLPR DCFVVSEGAN TMDIGRTVLQ NYLPRHRLDA
       430        440        450        460        470        480
GTFGTMGVGL GFAIAAAVVA KDRSPGQWII CVEGDSAFGF SGMEVETICR YNLPIILLVV
       490        500        510        520        530        540
NNNGIYQGFD TDTWKEMLKF QDATAVVPPM CLLPNSHYEQ VMTAFGGKGY FVQTPEELQK
       550        560        570
SLRQSLADTT KPSLINIMIE PQATRKAQDF HWLTRSNM         10         20         30         40         50         60
MPDSNFAERS EEQVSGAKVI AQALKTQDVE YIFGIVGIPV TEIAIAAQQL GIKYIGMRNE
        70         80         90        100        110        120
QAACYAASAI GYLTSRPGVC LVVSGPGLIH ALGGMANANM NCWPLLVIGG SSERNQETMG
       130        140        150        160        170        180
AFQEFPQVEA CRLYTKFSAR PSSIEAIPFV IEKAVRSSIY GRPGACYVDI PADFVNLQVN
       190        200        210        220        230        240
VNSIKYMERC MSPPISMAET SAVCTAASVI RNAKQPLLII GKGAAYAHAE ESIKKLVEQY
       250        260        270        280        290        300
KLPFLPTPMG KGVVPDNHPY CVGAARSRAL QFADVIVLFG ARLNWILHFG LPPRYQPDVK
       310        320        330        340        350        360
FIQVDICAEE LGNNVKPAVT LLGNIHAVTK QLLEELDKTP WQYPPESKWW KTLREKMKSN
       370        380        390        400        410        420
EAASKELASK KSLPMNYYTV FYHVQEQLPR DCFVVSEGAN TMDIGRTVLQ NYLPRHRLDA
       430        440        450        460        470        480
GTFGTMGVGL GFAIAAAVVA KDRSPGQWII CVEGDSAFGF SGMEVETICR YNLPIILLVV
       490        500        510        520        530        540
NNNGIYQGFD TDTWKEMLKF QDATAVVPPM CLLPNSHYEQ VMTAFGGKGY FVQTPEELQK
       550        560        570
SLRQSLADTT KPSLINIMIE PQATRKAQDF HWLTRSNM         10         20         30         40         50         60
MPDSNFAERS EEQVSGAKVI AQALKTQDVE YIFGIVGIPV TEIAIAAQQL GIKYIGMRNE
        70         80         90        100        110        120
QAACYAASAI GYLTSRPGVC LVVSGPGLIH ALGGMANANM NCWPLLVIGG SSERNQETMG
       130        140        150        160        170        180
AFQEFPQVEA CRLYTKFSAR PSSIEAIPFV IEKAVRSSIY GRPGACYVDI PADFVNLQVN
       190        200        210        220        230        240
VNSIKYMERC MSPPISMAET SAVCTAASVI RNAKQPLLII GKGAAYAHAE ESIKKLVEQY
       250        260        270        280        290        300
KLPFLPTPMG KGVVPDNHPY CVGAARSRAL QFADVIVLFG ARLNWILHFG LPPRYQPDVK
       310        320        330        340        350        360
FIQVDICAEE LGNNVKPAVT LLGNIHAVTK QLLEELDKTP WQYPPESKWW KTLREKMKSN
       370        380        390        400        410        420
EAASKELASK KSLPMNYYTV FYHVQEQLPR DCFVVSEGAN TMDIGRTVLQ NYLPRHRLDA
       430        440        450        460        470        480
GTFGTMGVGL GFAIAAAVVA KDRSPGQWII CVEGDSAFGF SGMEVETICR YNLPIILLVV
       490        500        510        520        530        540
NNNGIYQGFD TDTWKEMLKF QDATAVVPPM CLLPNSHYEQ VMTAFGGKGY FVQTPEELQK
       550        560        570
SLRQSLADTT KPSLINIMIE PQATRKAQDF HWLTRSNM

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9UJ83-1-unknown	MPDSNF...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9UJ83-1-unknown	MPDSNF...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt76722
Q9UJ83-1-unknown	MPDSNF...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt76723
Q9UJ83-1-unknown	MPDSNF...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt76724
Q9UJ83-2-unknown	PDSNFA...	2		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9UJ83-2-unknown	PDSNFA...	2		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9UJ83-2-unknown	PDSNFA...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162355
Q9UJ83-2-unknown	PDSNFA...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162356
Q9UJ83-2-unknown	PDSNFA...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162357

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LIIGKG	222	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000395352
...LIIGKG	222	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt113306
...LIIGKG	222	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt113304
...LIIGKG	222	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt113305
...TRSNM	578	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...TRSNM	578	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72342
...TRSNM	578	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72341
...TRSNM	578	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72340

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)