TopFIND 4.0

Q9UK80: Ubiquitin carboxyl-terminal hydrolase 21

General Information

Protein names
- Ubiquitin carboxyl-terminal hydrolase 21
- 3.4.19.12
- Deubiquitinating enzyme 21
- Ubiquitin thioesterase 21
- Ubiquitin-specific-processing protease 21
Gene names USP21
Organism Homo sapiens
Protease Family
Protease ID C19.034
Chromosome location
UniProt ID Q9UK80

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MPQASEHRLG RTREPPVNIQ PRVGSKLPFA PRARSKERRN PASGPNPMLR PLPPRPGLPD 
        70         80         90        100        110        120 
ERLKKLELGR GRTSGPRPRG PLRADHGVPL PGSPPPTVAL PLPSRTNLAR SKSVSSGDLR 
       130        140        150        160        170        180 
PMGIALGGHR GTGELGAALS RLALRPEPPT LRRSTSLRRL GGFPGPPTLF SIRTEPPASH 
       190        200        210        220        230        240 
GSFHMISARS SEPFYSDDKM AHHTLLLGSG HVGLRNLGNT CFLNAVLQCL SSTRPLRDFC 
       250        260        270        280        290        300 
LRRDFRQEVP GGGRAQELTE AFADVIGALW HPDSCEAVNP TRFRAVFQKY VPSFSGYSQQ 
       310        320        330        340        350        360 
DAQEFLKLLM ERLHLEINRR GRRAPPILAN GPVPSPPRRG GALLEEPELS DDDRANLMWK 
       370        380        390        400        410        420 
RYLEREDSKI VDLFVGQLKS CLKCQACGYR STTFEVFCDL SLPIPKKGFA GGKVSLRDCF 
       430        440        450        460        470        480 
NLFTKEEELE SENAPVCDRC RQKTRSTKKL TVQRFPRILV LHLNRFSASR GSIKKSSVGV 
       490        500        510        520        530        540 
DFPLQRLSLG DFASDKAGSP VYQLYALCNH SGSVHYGHYT ALCRCQTGWH VYNDSRVSPV 
       550        560    
SENQVASSEG YVLFYQLMQE PPRCL

Isoforms

- Isoform 2 of Ubiquitin carboxyl-terminal hydrolase 21 - Isoform 3 of Ubiquitin carboxyl-terminal hydrolase 21

Sequence View

        10         20         30         40         50         60 
MPQASEHRLG RTREPPVNIQ PRVGSKLPFA PRARSKERRN PASGPNPMLR PLPPRPGLPD 
        70         80         90        100        110        120 
ERLKKLELGR GRTSGPRPRG PLRADHGVPL PGSPPPTVAL PLPSRTNLAR SKSVSSGDLR 
       130        140        150        160        170        180 
PMGIALGGHR GTGELGAALS RLALRPEPPT LRRSTSLRRL GGFPGPPTLF SIRTEPPASH 
       190        200        210        220        230        240 
GSFHMISARS SEPFYSDDKM AHHTLLLGSG HVGLRNLGNT CFLNAVLQCL SSTRPLRDFC 
       250        260        270        280        290        300 
LRRDFRQEVP GGGRAQELTE AFADVIGALW HPDSCEAVNP TRFRAVFQKY VPSFSGYSQQ 
       310        320        330        340        350        360 
DAQEFLKLLM ERLHLEINRR GRRAPPILAN GPVPSPPRRG GALLEEPELS DDDRANLMWK 
       370        380        390        400        410        420 
RYLEREDSKI VDLFVGQLKS CLKCQACGYR STTFEVFCDL SLPIPKKGFA GGKVSLRDCF 
       430        440        450        460        470        480 
NLFTKEEELE SENAPVCDRC RQKTRSTKKL TVQRFPRILV LHLNRFSASR GSIKKSSVGV 
       490        500        510        520        530        540 
DFPLQRLSLG DFASDKAGSP VYQLYALCNH SGSVHYGHYT ALCRCQTGWH VYNDSRVSPV 
       550        560    
SENQVASSEG YVLFYQLMQE PPRCL         10         20         30         40         50         60 
MPQASEHRLG RTREPPVNIQ PRVGSKLPFA PRARSKERRN PASGPNPMLR PLPPRPGLPD 
        70         80         90        100        110        120 
ERLKKLELGR GRTSGPRPRG PLRADHGVPL PGSPPPTVAL PLPSRTNLAR SKSVSSGDLR 
       130        140        150        160        170        180 
PMGIALGGHR GTGELGAALS RLALRPEPPT LRRSTSLRRL GGFPGPPTLF SIRTEPPASH 
       190        200        210        220        230        240 
GSFHMISARS SEPFYSDDKM AHHTLLLGSG HVGLRNLGNT CFLNAVLQCL SSTRPLRDFC 
       250        260        270        280        290        300 
LRRDFRQEVP GGGRAQELTE AFADVIGALW HPDSCEAVNP TRFRAVFQKY VPSFSGYSQQ 
       310        320        330        340        350        360 
DAQEFLKLLM ERLHLEINRR GRRAPPILAN GPVPSPPRRG GALLEEPELS DDDRANLMWK 
       370        380        390        400        410        420 
RYLEREDSKI VDLFVGQLKS CLKCQACGYR STTFEVFCDL SLPIPKKGFA GGKVSLRDCF 
       430        440        450        460        470        480 
NLFTKEEELE SENAPVCDRC RQKTRSTKKL TVQRFPRILV LHLNRFSASR GSIKKSSVGV 
       490        500        510        520        530        540 
DFPLQRLSLG DFASDKAGSP VYQLYALCNH SGSVHYGHYT ALCRCQTGWH VYNDSRVSPV 
       550        560    
SENQVASSEG YVLFYQLMQE PPRCL



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Evidence Names:


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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q9UK80-1-unknown MPQASE... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q9UK80-1-unknown MPQASE... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt93656
    Q9UK80-1-unknown MPQASE... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt93657

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...PPRCL 565 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...PPRCL 565 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt89275

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)