Q9UKF6: Cleavage and polyadenylation specificity factor subunit 3

General Information

Protein names	- Cleavage and polyadenylation specificity factor subunit 3 - 3.1.27.- {ECO:0000269\|PubMed:15037765, ECO:0000269\|PubMed:17128255} - Cleavage and polyadenylation specificity factor 73 kDa subunit - CPSF 73 kDa subunit - mRNA 3'-end-processing endonuclease CPSF-73
Gene names	CPSF3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9UKF6

4 N-termini

3 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSAIPAEESD QLLIRPLGAG QEVGRSCIIL EFKGRKIMLD CGIHPGLEGM DALPYIDLID
        70         80         90        100        110        120
PAEIDLLLIS HFHLDHCGAL PWFLQKTSFK GRTFMTHATK AIYRWLLSDY VKVSNISADD
       130        140        150        160        170        180
MLYTETDLEE SMDKIETINF HEVKEVAGIK FWCYHAGHVL GAAMFMIEIA GVKLLYTGDF
       190        200        210        220        230        240
SRQEDRHLMA AEIPNIKPDI LIIESTYGTH IHEKREEREA RFCNTVHDIV NRGGRGLIPV
       250        260        270        280        290        300
FALGRAQELL LILDEYWQNH PELHDIPIYY ASSLAKKCMA VYQTYVNAMN DKIRKQININ
       310        320        330        340        350        360
NPFVFKHISN LKSMDHFDDI GPSVVMASPG MMQSGLSREL FESWCTDKRN GVIIAGYCVE
       370        380        390        400        410        420
GTLAKHIMSE PEEITTMSGQ KLPLKMSVDY ISFSAHTDYQ QTSEFIRALK PPHVILVHGE
       430        440        450        460        470        480
QNEMARLKAA LIREYEDNDE VHIEVHNPRN TEAVTLNFRG EKLAKVMGFL ADKKPEQGQR
       490        500        510        520        530        540
VSGILVKRNF NYHILSPCDL SNYTDLAMST VKQTQAIPYT GPFNLLCYQL QKLTGDVEEL
       550        560        570        580        590        600
EIQEKPALKV FKNITVIQEP GMVVLEWLAN PSNDMYADTV TTVILEVQSN PKIRKGAVQK
       610        620        630        640        650        660
VSKKLEMHVY SKRLEIMLQD IFGEDCVSVK DDSILSVTVD GKTANLNLET RTVECEEGSE
       670        680
DDESLREMVE LAAQRLYEAL TPVH

Isoforms

Sequence View

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Evidence Codes:

Methodology:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9UKF6-2-unknown	MSAIPA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9UKF6-2-Acetylation	SAIPAE...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9UKF6-2-Acetylation	SAIPAE...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9UKF6-2-Acetylation	SAIPAE...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q9UKF6-2-Acetylation	SAIPAE...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9UKF6-38-unknown	MLDCGI...	38		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000419744
Q9UKF6-38-unknown	MLDCGI...	38		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000418957
Q9UKF6-468-	GFLADK...	468			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...IAGVKL	173	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000419744
...LTPVH	684		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...LTPVH	684		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...LTPVH	684	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...LTPVH	684		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...LTPVH	684		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)