Q9UKG9: Peroxisomal carnitine O-octanoyltransferase

General Information

Protein names	- Peroxisomal carnitine O-octanoyltransferase - COT - 2.3.1.137 {ECO:0000269\|PubMed:10486279}
Gene names	CROT
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9UKG9

2 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Peroxisomal carnitine O-octanoyltransferase - Isoform 3 of Peroxisomal carnitine O-octanoyltransferase

Sequence View

        10         20         30         40         50         60
MENQLAKSTE ERTFQYQDSL PSLPVPSLEE SLKKYLESVK PFANQEEYKK TEEIVQKFQS
        70         80         90        100        110        120
GIGEKLHQKL LERAKGKRNW LEEWWLNVAY LDVRIPSQLN VNFAGPAAHF EHYWPPKEGT
       130        140        150        160        170        180
QLERGSITLW HNLNYWQLLR KEKVPVHKVG NTPLDMNQFR MLFSTCKVPG ITRDSIMNYF
       190        200        210        220        230        240
RTESEGRSPN HIVVLCRGRA FVFDVIHEGC LVTPPELLRQ LTYIHKKCHS EPDGPGIAAL
       250        260        270        280        290        300
TSEERTRWAK AREYLIGLDP ENLALLEKIQ SSLLVYSMED SSPHVTPEDY SEIIAAILIG
       310        320        330        340        350        360
DPTVRWGDKS YNLISFSNGV FGCNCDHAPF DAMIMVNISY YVDEKIFQNE GRWKGSEKVR
       370        380        390        400        410        420
DIPLPEELIF IVDEKVLNDI NQAKAQYLRE ASDLQIAAYA FTSFGKKLTK NKMLHPDTFI
       430        440        450        460        470        480
QLALQLAYYR LHGHPGCCYE TAMTRHFYHG RTETMRSCTV EAVRWCQSMQ DPSVNLRERQ
       490        500        510        520        530        540
QKMLQAFAKH NKMMKDCSAG KGFDRHLLGL LLIAKEEGLP VPELFTDPLF SKSGGGGNFV
       550        560        570        580        590        600
LSTSLVGYLR VQGVVVPMVH NGYGFFYHIR DDRFVVACSA WKSCPETDAE KLVQLTFCAF
       610
HDMIQLMNST HL         10         20         30         40         50         60
MENQLAKSTE ERTFQYQDSL PSLPVPSLEE SLKKYLESVK PFANQEEYKK TEEIVQKFQS
        70         80         90        100        110        120
GIGEKLHQKL LERAKGKRNW LEEWWLNVAY LDVRIPSQLN VNFAGPAAHF EHYWPPKEGT
       130        140        150        160        170        180
QLERGSITLW HNLNYWQLLR KEKVPVHKVG NTPLDMNQFR MLFSTCKVPG ITRDSIMNYF
       190        200        210        220        230        240
RTESEGRSPN HIVVLCRGRA FVFDVIHEGC LVTPPELLRQ LTYIHKKCHS EPDGPGIAAL
       250        260        270        280        290        300
TSEERTRWAK AREYLIGLDP ENLALLEKIQ SSLLVYSMED SSPHVTPEDY SEIIAAILIG
       310        320        330        340        350        360
DPTVRWGDKS YNLISFSNGV FGCNCDHAPF DAMIMVNISY YVDEKIFQNE GRWKGSEKVR
       370        380        390        400        410        420
DIPLPEELIF IVDEKVLNDI NQAKAQYLRE ASDLQIAAYA FTSFGKKLTK NKMLHPDTFI
       430        440        450        460        470        480
QLALQLAYYR LHGHPGCCYE TAMTRHFYHG RTETMRSCTV EAVRWCQSMQ DPSVNLRERQ
       490        500        510        520        530        540
QKMLQAFAKH NKMMKDCSAG KGFDRHLLGL LLIAKEEGLP VPELFTDPLF SKSGGGGNFV
       550        560        570        580        590        600
LSTSLVGYLR VQGVVVPMVH NGYGFFYHIR DDRFVVACSA WKSCPETDAE KLVQLTFCAF
       610
HDMIQLMNST HL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9UKG9-1-unknown	MENQLA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt83658
Q9UKG9-1-unknown	MENQLA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt83659
Q9UKG9-1-Acetylation	MENQLA...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9UKG9-1-Acetylation	MENQLA...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9UKG9-1-Acetylation	MENQLA...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9UKG9-1-Acetylation	MENQLA...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt108847
Q9UKG9-1-Acetylation	MENQLA...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt108848

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...NSTHL	612	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
	...NSTHL	612	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt79277

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)