Q9UKP4: A disintegrin and metalloproteinase with thrombospondin motifs 7

General Information

Protein names	- A disintegrin and metalloproteinase with thrombospondin motifs 7 - ADAM-TS 7 - ADAM-TS7 - ADAMTS-7 - 3.4.24.- - COMPase
Gene names	ADAMTS7
Organism	Homo sapiens
Protease Family
Protease ID	M12.231
Chromosome location
UniProt ID	Q9UKP4

8 N-termini

8 C-termini

7 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPGGPSPRSP APLLRPLLLL LCALAPGAPG PAPGRATEGR AALDIVHPVR VDAGGSFLSY
        70         80         90        100        110        120
ELWPRALRKR DVSVRRDAPA FYELQYRGRE LRFNLTANQH LLAPGFVSET RRRGGLGRAH
       130        140        150        160        170        180
IRAHTPACHL LGEVQDPELE GGLAAISACD GLKGVFQLSN EDYFIEPLDS APARPGHAQP
       190        200        210        220        230        240
HVVYKRQAPE RLAQRGDSSA PSTCGVQVYP ELESRRERWE QRQQWRRPRL RRLHQRSVSK
       250        260        270        280        290        300
EKWVETLVVA DAKMVEYHGQ PQVESYVLTI MNMVAGLFHD PSIGNPIHIT IVRLVLLEDE
       310        320        330        340        350        360
EEDLKITHHA DNTLKSFCKW QKSINMKGDA HPLHHDTAIL LTRKDLCAAM NRPCETLGLS
       370        380        390        400        410        420
HVAGMCQPHR SCSINEDTGL PLAFTVAHEL GHSFGIQHDG SGNDCEPVGK RPFIMSPQLL
       430        440        450        460        470        480
YDAAPLTWSR CSRQYITRFL DRGWGLCLDD PPAKDIIDFP SVPPGVLYDV SHQCRLQYGA
       490        500        510        520        530        540
YSAFCEDMDN VCHTLWCSVG TTCHSKLDAA VDGTRCGENK WCLSGECVPV GFRPEAVDGG
       550        560        570        580        590        600
WSGWSAWSIC SRSCGMGVQS AERQCTQPTP KYKGRYCVGE RKRFRLCNLQ ACPAGRPSFR
       610        620        630        640        650        660
HVQCSHFDAM LYKGQLHTWV PVVNDVNPCE LHCRPANEYF AEKLRDAVVD GTPCYQVRAS
       670        680        690        700        710        720
RDLCINGICK NVGCDFEIDS GAMEDRCGVC HGNGSTCHTV SGTFEEAEGL GYVDVGLIPA
       730        740        750        760        770        780
GAREIRIQEV AEAANFLALR SEDPEKYFLN GGWTIQWNGD YQVAGTTFTY ARRGNWENLT
       790        800        810        820        830        840
SPGPTKEPVW IQLLFQESNP GVHYEYTIHR EAGGHDEVPP PVFSWHYGPW TKCTVTCGRG
       850        860        870        880        890        900
VQRQNVYCLE RQAGPVDEEH CDPLGRPDDQ QRKCSEQPCP ARWWAGEWQL CSSSCGPGGL
       910        920        930        940        950        960
SRRAVLCIRS VGLDEQSALE PPACEHLPRP PTETPCNRHV PCPATWAVGN WSQCSVTCGE
       970        980        990       1000       1010       1020
GTQRRNVLCT NDTGVPCDEA QQPASEVTCS LPLCRWPLGT LGPEGSGSGS SSHELFNEAD
      1030       1040       1050       1060       1070       1080
FIPHHLAPRP SPASSPKPGT MGNAIEEEAP ELDLPGPVFV DDFYYDYNFI NFHEDLSYGP
      1090       1100       1110       1120       1130       1140
SEEPDLDLAG TGDRTPPPHS HPAAPSTGSP VPATEPPAAK EEGVLGPWSP SPWPSQAGRS
      1150       1160       1170       1180       1190       1200
PPPPSEQTPG NPLINFLPEE DTPIGAPDLG LPSLSWPRVS TDGLQTPATP ESQNDFPVGK
      1210       1220       1230       1240       1250       1260
DSQSQLPPPW RDRTNEVFKD DEEPKGRGAP HLPPRPSSTL PPLSPVGSTH SSPSPDVAEL
      1270       1280       1290       1300       1310       1320
WTGGTVAWEP ALEGGLGPVD SELWPTVGVA SLLPPPIAPL PEMKVRDSSL EPGTPSFPTP
      1330       1340       1350       1360       1370       1380
GPGSWDLQTV AVWGTFLPTT LTGLGHMPEP ALNPGPKGQP ESLSPEVPLS SRLLSTPAWD
      1390       1400       1410       1420       1430       1440
SPANSHRVPE TQPLAPSLAE AGPPADPLVV RNAGWQAGNW SECSTTCGLG AVWRPVRCSS
      1450       1460       1470       1480       1490       1500
GRDEDCAPAG RPQPARRCHL RPCATWHSGN WSKCSRSCGG GSSVRDVQCV DTRDLRPLRP
      1510       1520       1530       1540       1550       1560
FHCQPGPAKP PAHRPCGAQP CLSWYTSSWR ECSEACGGGE QQRLVTCPEP GLCEEALRPN
      1570       1580       1590       1600       1610       1620
TTRPCNTHPC TQWVVGPWGQ CSGPCGGGVQ RRLVKCVNTQ TGLPEEDSDQ CGHEAWPESS
      1630       1640       1650       1660       1670       1680
RPCGTEDCEP VEPPRCERDR LSFGFCETLR LLGRCQLPTI RTQCCRSCSP PSHGAPSRGH

QRVARR

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

8 N-termini - 8 C-termini - 7 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9UKP4-28-unknown	APGPAP...	28	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9UKP4-69-unknown	KRDVSV...	69	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9840
Q9UKP4-71-unknown	DVSVRR...	71	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9841
Q9UKP4-93-unknown	FNLTAN...	93	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9842
Q9UKP4-219-unknown	WEQRQQ...	219	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9843
Q9UKP4-230-unknown	LRRLHQ...	230	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9844
Q9UKP4-233-unknown	LHQRSV...	233	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9845
Q9UKP4-237-unknown	SVSKEK...	237	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9UKP4-237-unknown	SVSKEK...	237	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9846

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PRALRK	68	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9840
...ALRKRD	70	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9841
...GRELRF	92	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9842
...SRRERW	218	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9843
...WRRPRL	229	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9844
...PRLRRL	232	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9845
...RLHQRS	236	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9846
...RVARR	1686	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
FURIN_HUMAN	68	ALRK.\|.KRDV	inferred from experiment	unknown	MEROPS	Apte SS	Somerville RP et al.:ADAMTS7B, the full-length produ... (S08.071)	15192113,
FURIN_HUMAN	70	RKRD.\|.DVSV	inferred from experiment	unknown	MEROPS	Apte SS	Somerville RP et al.:ADAMTS7B, the full-length produ... (S08.071)	15192113,
FURIN_HUMAN	92	ELRF.\|.FNLT	inferred from experiment	unknown	MEROPS	Apte SS	Somerville RP et al.:ADAMTS7B, the full-length produ... (S08.071)	15192113,
FURIN_HUMAN	218	RERW.\|.WEQR	inferred from experiment	unknown	MEROPS	Apte SS	Somerville RP et al.:ADAMTS7B, the full-length produ... (S08.071)	15192113,
FURIN_HUMAN	229	RPRL.\|.LRRL	inferred from experiment	unknown	MEROPS	Apte SS	Somerville RP et al.:ADAMTS7B, the full-length produ... (S08.071)	15192113,
FURIN_HUMAN	232	LRRL.\|.LHQR	inferred from experiment	unknown	MEROPS	Apte SS	Hurskainen TL et al.:ADAM-TS5, ADAM-TS6, and ADAM-TS... (S08.071)	10464288,
FURIN_HUMAN	236	HQRS.\|.SVSK	inferred from experiment	unknown	MEROPS	Apte SS	Somerville RP et al.:ADAMTS7B, the full-length produ... (S08.071)	15192113,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)