Q9UKP5: A disintegrin and metalloproteinase with thrombospondin motifs 6

General Information

Protein names	- A disintegrin and metalloproteinase with thrombospondin motifs 6 - ADAM-TS 6 - ADAM-TS6 - ADAMTS-6 - 3.4.24.-
Gene names	ADAMTS6
Organism	Homo sapiens
Protease Family
Protease ID	M12.230
Chromosome location
UniProt ID	Q9UKP5

4 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of A disintegrin and metalloproteinase with thrombospondin motifs 6 - Isoform 3 of A disintegrin and metalloproteinase with thrombospondin motifs 6 - Isoform 4 of A disintegrin and metalloproteinase with thrombospondin motifs 6

Sequence View

        10         20         30         40         50         60
MEILWKTLTW ILSLIMASSE FHSDHRLSYS SQEEFLTYLE HYQLTIPIRV DQNGAFLSFT
        70         80         90        100        110        120
VKNDKHSRRR RSMDPIDPQQ AVSKLFFKLS AYGKHFHLNL TLNTDFVSKH FTVEYWGKDG
       130        140        150        160        170        180
PQWKHDFLDN CHYTGYLQDQ RSTTKVALSN CVGLHGVIAT EDEEYFIEPL KNTTEDSKHF
       190        200        210        220        230        240
SYENGHPHVI YKKSALQQRH LYDHSHCGVS DFTRSGKPWW LNDTSTVSYS LPINNTHIHH
       250        260        270        280        290        300
RQKRSVSIER FVETLVVADK MMVGYHGRKD IEHYILSVMN IVAKLYRDSS LGNVVNIIVA
       310        320        330        340        350        360
RLIVLTEDQP NLEINHHADK SLDSFCKWQK SILSHQSDGN TIPENGIAHH DNAVLITRYD
       370        380        390        400        410        420
ICTYKNKPCG TLGLASVAGM CEPERSCSIN EDIGLGSAFT IAHEIGHNFG MNHDGIGNSC
       430        440        450        460        470        480
GTKGHEAAKL MAAHITANTN PFSWSACSRD YITSFLDSGR GTCLDNEPPK RDFLYPAVAP
       490        500        510        520        530        540
GQVYDADEQC RFQYGATSRQ CKYGEVCREL WCLSKSNRCV TNSIPAAEGT LCQTGNIEKG
       550        560        570        580        590        600
WCYQGDCVPF GTWPQSIDGG WGPWSLWGEC SRTCGGGVSS SLRHCDSPAP SGGGKYCLGE
       610        620        630        640        650        660
RKRYRSCNTD PCPLGSRDFR EKQCADFDNM PFRGKYYNWK PYTGGGVKPC ALNCLAEGYN
       670        680        690        700        710        720
FYTERAPAVI DGTQCNADSL DICINGECKH VGCDNILGSD AREDRCRVCG GDGSTCDAIE
       730        740        750        760        770        780
GFFNDSLPRG GYMEVVQIPR GSVHIEVREV AMSKNYIALK SEGDDYYING AWTIDWPRKF
       790        800        810        820        830        840
DVAGTAFHYK RPTDEPESLE ALGPTSENLI VMVLLQEQNL GIRYKFNVPI TRTGSGDNEV
       850        860        870        880        890        900
GFTWNHQPWS ECSATCAGGV QRQEVVCKRL DDNSIVQNNY CDPDSKPPEN QRACNTEPCP
       910        920        930        940        950        960
PEWFIGDWLE CSKTCDGGMR TRAVLCIRKI GPSEEETLDY SGCLTHRPVE KEPCNNQSCP
       970        980        990       1000       1010       1020
PQWVALDWSE CTPKCGPGFK HRIVLCKSSD LSKTFPAAQC PEESKPPVRI RCSLGRCPPP
      1030       1040       1050       1060       1070       1080
RWVTGDWGQC SAQCGLGQQM RTVQCLSYTG QASSDCLETV RPPSMQQCES KCDSTPISNT
      1090       1100       1110
EECKDVNKVA YCPLVLKFKF CSRAYFRQMC CKTCQGH         10         20         30         40         50         60
MEILWKTLTW ILSLIMASSE FHSDHRLSYS SQEEFLTYLE HYQLTIPIRV DQNGAFLSFT
        70         80         90        100        110        120
VKNDKHSRRR RSMDPIDPQQ AVSKLFFKLS AYGKHFHLNL TLNTDFVSKH FTVEYWGKDG
       130        140        150        160        170        180
PQWKHDFLDN CHYTGYLQDQ RSTTKVALSN CVGLHGVIAT EDEEYFIEPL KNTTEDSKHF
       190        200        210        220        230        240
SYENGHPHVI YKKSALQQRH LYDHSHCGVS DFTRSGKPWW LNDTSTVSYS LPINNTHIHH
       250        260        270        280        290        300
RQKRSVSIER FVETLVVADK MMVGYHGRKD IEHYILSVMN IVAKLYRDSS LGNVVNIIVA
       310        320        330        340        350        360
RLIVLTEDQP NLEINHHADK SLDSFCKWQK SILSHQSDGN TIPENGIAHH DNAVLITRYD
       370        380        390        400        410        420
ICTYKNKPCG TLGLASVAGM CEPERSCSIN EDIGLGSAFT IAHEIGHNFG MNHDGIGNSC
       430        440        450        460        470        480
GTKGHEAAKL MAAHITANTN PFSWSACSRD YITSFLDSGR GTCLDNEPPK RDFLYPAVAP
       490        500        510        520        530        540
GQVYDADEQC RFQYGATSRQ CKYGEVCREL WCLSKSNRCV TNSIPAAEGT LCQTGNIEKG
       550        560        570        580        590        600
WCYQGDCVPF GTWPQSIDGG WGPWSLWGEC SRTCGGGVSS SLRHCDSPAP SGGGKYCLGE
       610        620        630        640        650        660
RKRYRSCNTD PCPLGSRDFR EKQCADFDNM PFRGKYYNWK PYTGGGVKPC ALNCLAEGYN
       670        680        690        700        710        720
FYTERAPAVI DGTQCNADSL DICINGECKH VGCDNILGSD AREDRCRVCG GDGSTCDAIE
       730        740        750        760        770        780
GFFNDSLPRG GYMEVVQIPR GSVHIEVREV AMSKNYIALK SEGDDYYING AWTIDWPRKF
       790        800        810        820        830        840
DVAGTAFHYK RPTDEPESLE ALGPTSENLI VMVLLQEQNL GIRYKFNVPI TRTGSGDNEV
       850        860        870        880        890        900
GFTWNHQPWS ECSATCAGGV QRQEVVCKRL DDNSIVQNNY CDPDSKPPEN QRACNTEPCP
       910        920        930        940        950        960
PEWFIGDWLE CSKTCDGGMR TRAVLCIRKI GPSEEETLDY SGCLTHRPVE KEPCNNQSCP
       970        980        990       1000       1010       1020
PQWVALDWSE CTPKCGPGFK HRIVLCKSSD LSKTFPAAQC PEESKPPVRI RCSLGRCPPP
      1030       1040       1050       1060       1070       1080
RWVTGDWGQC SAQCGLGQQM RTVQCLSYTG QASSDCLETV RPPSMQQCES KCDSTPISNT
      1090       1100       1110
EECKDVNKVA YCPLVLKFKF CSRAYFRQMC CKTCQGH         10         20         30         40         50         60
MEILWKTLTW ILSLIMASSE FHSDHRLSYS SQEEFLTYLE HYQLTIPIRV DQNGAFLSFT
        70         80         90        100        110        120
VKNDKHSRRR RSMDPIDPQQ AVSKLFFKLS AYGKHFHLNL TLNTDFVSKH FTVEYWGKDG
       130        140        150        160        170        180
PQWKHDFLDN CHYTGYLQDQ RSTTKVALSN CVGLHGVIAT EDEEYFIEPL KNTTEDSKHF
       190        200        210        220        230        240
SYENGHPHVI YKKSALQQRH LYDHSHCGVS DFTRSGKPWW LNDTSTVSYS LPINNTHIHH
       250        260        270        280        290        300
RQKRSVSIER FVETLVVADK MMVGYHGRKD IEHYILSVMN IVAKLYRDSS LGNVVNIIVA
       310        320        330        340        350        360
RLIVLTEDQP NLEINHHADK SLDSFCKWQK SILSHQSDGN TIPENGIAHH DNAVLITRYD
       370        380        390        400        410        420
ICTYKNKPCG TLGLASVAGM CEPERSCSIN EDIGLGSAFT IAHEIGHNFG MNHDGIGNSC
       430        440        450        460        470        480
GTKGHEAAKL MAAHITANTN PFSWSACSRD YITSFLDSGR GTCLDNEPPK RDFLYPAVAP
       490        500        510        520        530        540
GQVYDADEQC RFQYGATSRQ CKYGEVCREL WCLSKSNRCV TNSIPAAEGT LCQTGNIEKG
       550        560        570        580        590        600
WCYQGDCVPF GTWPQSIDGG WGPWSLWGEC SRTCGGGVSS SLRHCDSPAP SGGGKYCLGE
       610        620        630        640        650        660
RKRYRSCNTD PCPLGSRDFR EKQCADFDNM PFRGKYYNWK PYTGGGVKPC ALNCLAEGYN
       670        680        690        700        710        720
FYTERAPAVI DGTQCNADSL DICINGECKH VGCDNILGSD AREDRCRVCG GDGSTCDAIE
       730        740        750        760        770        780
GFFNDSLPRG GYMEVVQIPR GSVHIEVREV AMSKNYIALK SEGDDYYING AWTIDWPRKF
       790        800        810        820        830        840
DVAGTAFHYK RPTDEPESLE ALGPTSENLI VMVLLQEQNL GIRYKFNVPI TRTGSGDNEV
       850        860        870        880        890        900
GFTWNHQPWS ECSATCAGGV QRQEVVCKRL DDNSIVQNNY CDPDSKPPEN QRACNTEPCP
       910        920        930        940        950        960
PEWFIGDWLE CSKTCDGGMR TRAVLCIRKI GPSEEETLDY SGCLTHRPVE KEPCNNQSCP
       970        980        990       1000       1010       1020
PQWVALDWSE CTPKCGPGFK HRIVLCKSSD LSKTFPAAQC PEESKPPVRI RCSLGRCPPP
      1030       1040       1050       1060       1070       1080
RWVTGDWGQC SAQCGLGQQM RTVQCLSYTG QASSDCLETV RPPSMQQCES KCDSTPISNT
      1090       1100       1110
EECKDVNKVA YCPLVLKFKF CSRAYFRQMC CKTCQGH

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9UKP5-1-unknown	MEILWK...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt67984
Q9UKP5-1-unknown	MEILWK...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt67985
Q9UKP5-1-unknown	MEILWK...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt67986
Q9UKP5-22-unknown	HSDHRL...	22	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9UKP5-22-unknown	HSDHRL...	22	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112882
Q9UKP5-22-unknown	HSDHRL...	22	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112883
Q9UKP5-22-unknown	HSDHRL...	22	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112884
Q9UKP5-72-unknown	SMDPID...	72	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9847
Q9UKP5-72-unknown	SMDPID...	72	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt140780
Q9UKP5-72-unknown	SMDPID...	72	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt140781
Q9UKP5-72-unknown	SMDPID...	72	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt140782
Q9UKP5-245-unknown	SVSIER...	245	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9UKP5-245-unknown	SVSIER...	245	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9851
Q9UKP5-245-unknown	SVSIER...	245	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116088
Q9UKP5-245-unknown	SVSIER...	245	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116089
Q9UKP5-245-unknown	SVSIER...	245	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116090
Q9UKP5-245-unknown	SVSIER...	245	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SRRRRS	71	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9847
...SRRRRS	71	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123915
...SRRRRS	71	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123916
...SRRRRS	71	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123917
...HRQKRS	244	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9851
...HRQKRS	244	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131636
...HRQKRS	244	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131638
...HRQKRS	244	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131639
...TCQGH	1117	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
FURIN_HUMAN	71	RRRS.\|.SMDP	inferred from experiment	unknown	MEROPS	Apte SS	Somerville RP et al.:Discovery and characterization ... (S08.071)	15355968,
FURIN_HUMAN	244	QKRS.\|.SVSI	inferred from experiment	unknown	MEROPS	Apte SS	Hurskainen TL et al.:ADAM-TS5, ADAM-TS6, and ADAM-TS... (S08.071)	10464288,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)