TopFIND 4.0

Q9UKU6: Thyrotropin-releasing hormone-degrading ectoenzyme

General Information

Protein names
- Thyrotropin-releasing hormone-degrading ectoenzyme
- TRH-DE
- TRH-degrading ectoenzyme
- 3.4.19.6
- Pyroglutamyl-peptidase II
- PAP-II
- TRH-specific aminopeptidase
- Thyroliberinase
Gene names TRHDE
Organism Homo sapiens
Protease Family
Protease ID M01.008
Chromosome location
UniProt ID Q9UKU6

1

N-termini

2

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MGEDDAALRA GSRGLSDPWA DSVGVRPRTT ERHIAVHKRL VLAFAVSLVA LLAVTMLAVL 
        70         80         90        100        110        120 
LSLRFDECGA SATPGADGGP SGFPERGGNG SLPGSARRNH HAGGDSWQPE AGGVASPGTT 
       130        140        150        160        170        180 
SAQPPSEEER EPWEPWTQLR LSGHLKPLHY NLMLTAFMEN FTFSGEVNVE IACRNATRYV 
       190        200        210        220        230        240 
VLHASRVAVE KVQLAEDRAF GAVPVAGFFL YPQTQVLVVV LNRTLDAQRN YNLKIIYNAL 
       250        260        270        280        290        300 
IENELLGFFR SSYVLHGERR FLGVTQFSPT HARKAFPCFD EPIYKATFKI SIKHQATYLS 
       310        320        330        340        350        360 
LSNMPVETSV FEEDGWVTDH FSQTPLMSTY YLAWAICNFT YRETTTKSGV VVRLYARPDA 
       370        380        390        400        410        420 
IRRGSGDYAL HITKRLIEFY EDYFKVPYSL PKLDLLAVPK HPYAAMENWG LSIFVEQRIL 
       430        440        450        460        470        480 
LDPSVSSISY LLDVTMVIVH EICHQWFGDL VTPVWWEDVW LKEGFAHYFE FVGTDYLYPG 
       490        500        510        520        530        540 
WNMEKQRFLT DVLHEVMLLD GLASSHPVSQ EVLQATDIDR VFDWIAYKKG AALIRMLANF 
       550        560        570        580        590        600 
MGHSVFQRGL QDYLTIHKYG NAARNDLWNT LSEALKRNGK YVNIQEVMDQ WTLQMGYPVI 
       610        620        630        640        650        660 
TILGNTTAEN RIIITQQHFI YDISAKTKAL KLQNNSYLWQ IPLTIVVGNR SHVSSEAIIW 
       670        680        690        700        710        720 
VSNKSEHHRI TYLDKGSWLL GNINQTGYFR VNYDLRNWRL LIDQLIRNHE VLSVSNRAGL 
       730        740        750        760        770        780 
IDDAFSLARA GYLPQNIPLE IIRYLSEEKD FLPWHAASRA LYPLDKLLDR MENYNIFNEY 
       790        800        810        820        830        840 
ILKQVATTYI KLGWPKNNFN GSLVQASYQH EELRREVIML ACSFGNKHCH QQASTLISDW 
       850        860        870        880        890        900 
ISSNRNRIPL NVRDIVYCTG VSLLDEDVWE FIWMKFHSTT AVSEKKILLE ALTCSDDRNL 
       910        920        930        940        950        960 
LNRLLNLSLN SEVVLDQDAI DVIIHVARNP HGRDLAWKFF RDKWKILNTR YGEALFMNSK 
       970        980        990       1000       1010       1020 
LISGVTEFLN TEGELKELKN FMKNYDGVAA ASFSRAVETV EANVRWKMLY QDELFQWLGK 
   
ALRH

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

1 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q9UKU6-1-unknown MGEDDA... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)