Q9UM00: Calcium load-activated calcium channel {ECO:0000305|PubMed:27212239}

General Information

Protein names	- Calcium load-activated calcium channel {ECO:0000305\|PubMed:27212239} - CLAC channel {ECO:0000305\|PubMed:27212239} - Transmembrane and coiled-coil domain-containing protein 1 {ECO:0000305} - Transmembrane and coiled-coil domains protein 4 {ECO:0000305} - Xenogeneic cross-immune protein PCIA3 {ECO:0000303\|Ref.2}
Gene names	TMCO1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9UM00

2 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Transmembrane and coiled-coil domain-containing protein 1 - Isoform 2 of Calcium load-activated calcium channel - Isoform 3 of Calcium load-activated calcium channel

Sequence View

        10         20         30         40         50         60
MPRKRKCDLR AVRVGLLLGG GGVYGSRFRF TFPGCRALSP WRVRVQRRRC EMSTMFADTL
        70         80         90        100        110        120
LIVFISVCTA LLAEGITWVL VYRTDKYKRL KAEVEKQSKK LEKKKETITE SAGRQQKKKI
       130        140        150        160        170        180
ERQEEKLKNN NRDLSMVRMK SMFAIGFCFT ALMGMFNSIF DGRVVAKLPF TPLSYIQGLS
       190        200        210        220        230
HRNLLGDDTT DCSFIFLYIL CTMSIRQNIQ KILGLAPSRA ATKQAGGFLG PPPPSGKFS         10         20         30         40         50         60
MPRKRKCDLR AVRVGLLLGG GGVYGSRFRF TFPGCRALSP WRVRVQRRRC EMSTMFADTL
        70         80         90        100        110        120
LIVFISVCTA LLAEGITWVL VYRTDKYKRL KAEVEKQSKK LEKKKETITE SAGRQQKKKI
       130        140        150        160        170        180
ERQEEKLKNN NRDLSMVRMK SMFAIGFCFT ALMGMFNSIF DGRVVAKLPF TPLSYIQGLS
       190        200        210        220        230
HRNLLGDDTT DCSFIFLYIL CTMSIRQNIQ KILGLAPSRA ATKQAGGFLG PPPPSGKFS         10         20         30         40         50         60
MPRKRKCDLR AVRVGLLLGG GGVYGSRFRF TFPGCRALSP WRVRVQRRRC EMSTMFADTL
        70         80         90        100        110        120
LIVFISVCTA LLAEGITWVL VYRTDKYKRL KAEVEKQSKK LEKKKETITE SAGRQQKKKI
       130        140        150        160        170        180
ERQEEKLKNN NRDLSMVRMK SMFAIGFCFT ALMGMFNSIF DGRVVAKLPF TPLSYIQGLS
       190        200        210        220        230
HRNLLGDDTT DCSFIFLYIL CTMSIRQNIQ KILGLAPSRA ATKQAGGFLG PPPPSGKFS

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9UM00-1-unknown	MPRKRK...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9UM00-1-unknown	MPRKRK...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt92458
Q9UM00-4-unknown	KRKCDL...	4	inferred from electronic annotation	unknown	TISdb	inferred from TISdb
Q9UM00-4-unknown	KRKCDL...	4	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt194613

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...LLGDDT	188		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...LLGDDT	188	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...LLGDDT	188	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt88076
...LLGDDT	188		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...LLGDDT	188		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)