TopFIND 4.0

Q9UMW8: Ubl carboxyl-terminal hydrolase 18

General Information

Protein names
- Ubl carboxyl-terminal hydrolase 18
- 3.4.19.-
- 43 kDa ISG15-specific protease
- hUBP43
- ISG15-specific-processing protease
- Ubl thioesterase 18
Gene names USP18
Organism Homo sapiens
Protease Family C19.030
Protease ID C19.030
Chromosome location
UniProt ID Q9UMW8

1

N-termini

1

C-termini

0

Cleavages

1

Substrates

Sequence

        10         20         30         40         50         60 
MSKAFGLLRQ ICQSILAESS QSPADLEEKK EEDSNMKREQ PRERPRAWDY PHGLVGLHNI 
        70         80         90        100        110        120 
GQTCCLNSLI QVFVMNVDFT RILKRITVPR GADEQRRSVP FQMLLLLEKM QDSRQKAVRP 
       130        140        150        160        170        180 
LELAYCLQKC NVPLFVQHDA AQLYLKLWNL IKDQITDVHL VERLQALYTI RVKDSLICVD 
       190        200        210        220        230        240 
CAMESSRNSS MLTLPLSLFD VDSKPLKTLE DALHCFFQPR ELSSKSKCFC ENCGKKTRGK 
       250        260        270        280        290        300 
QVLKLTHLPQ TLTIHLMRFS IRNSQTRKIC HSLYFPQSLD FSQILPMKRE SCDAEEQSGG 
       310        320        330        340        350        360 
QYELFAVIAH VGMADSGHYC VYIRNAVDGK WFCFNDSNIC LVSWEDIQCT YGNPNYHWQE 
       370    
TAYLLVYMKM EC

Isoforms

- Isoform 2 of Ubl carboxyl-terminal hydrolase 18

Sequence View

        10         20         30         40         50         60 
MSKAFGLLRQ ICQSILAESS QSPADLEEKK EEDSNMKREQ PRERPRAWDY PHGLVGLHNI 
        70         80         90        100        110        120 
GQTCCLNSLI QVFVMNVDFT RILKRITVPR GADEQRRSVP FQMLLLLEKM QDSRQKAVRP 
       130        140        150        160        170        180 
LELAYCLQKC NVPLFVQHDA AQLYLKLWNL IKDQITDVHL VERLQALYTI RVKDSLICVD 
       190        200        210        220        230        240 
CAMESSRNSS MLTLPLSLFD VDSKPLKTLE DALHCFFQPR ELSSKSKCFC ENCGKKTRGK 
       250        260        270        280        290        300 
QVLKLTHLPQ TLTIHLMRFS IRNSQTRKIC HSLYFPQSLD FSQILPMKRE SCDAEEQSGG 
       310        320        330        340        350        360 
QYELFAVIAH VGMADSGHYC VYIRNAVDGK WFCFNDSNIC LVSWEDIQCT YGNPNYHWQE 
       370    
TAYLLVYMKM EC



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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 1 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q9UMW8-1-unknown MSKAFG... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...MKMEC 372 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates