TopFIND 4.0

Q9UP79: A disintegrin and metalloproteinase with thrombospondin motifs 8

General Information

Protein names
- A disintegrin and metalloproteinase with thrombospondin motifs 8
- ADAM-TS 8
- ADAM-TS8
- ADAMTS-8
- 3.4.24.-
- METH-2
- METH-8
Gene names ADAMTS8
Organism Homo sapiens
Protease Family M12.226
Protease ID M12.226
Chromosome location
UniProt ID Q9UP79

2

N-termini

1

C-termini

0

Cleavages

3

Substrates

Sequence

        10         20         30         40         50         60 
MLPAPAAPRW PPLLLLLLLL LPLARGAPAR PAAGGQASEL VVPTRLPGSA GELALHLSAF 
        70         80         90        100        110        120 
GKGFVLRLAP DDSFLAPEFK IERLGGSGRA TGGERGLRGC FFSGTVNGEP ESLAAVSLCR 
       130        140        150        160        170        180 
GLSGSFLLDG EEFTIQPQGA GGSLAQPHRL QRWGPAGARP LPRGPEWEVE TGEGQRQERG 
       190        200        210        220        230        240 
DHQEDSEEES QEEEAEGASE PPPPLGATSR TKRFVSEARF VETLLVADAS MAAFYGADLQ 
       250        260        270        280        290        300 
NHILTLMSVA ARIYKHPSIK NSINLMVVKV LIVEDEKWGP EVSDNGGLTL RNFCNWQRRF 
       310        320        330        340        350        360 
NQPSDRHPEH YDTAILLTRQ NFCGQEGLCD TLGVADIGTI CDPNKSCSVI EDEGLQAAHT 
       370        380        390        400        410        420 
LAHELGHVLS MPHDDSKPCT RLFGPMGKHH VMAPLFVHLN QTLPWSPCSA MYLTELLDGG 
       430        440        450        460        470        480 
HGDCLLDAPA AALPLPTGLP GRMALYQLDQ QCRQIFGPDF RHCPNTSAQD VCAQLWCHTD 
       490        500        510        520        530        540 
GAEPLCHTKN GSLPWADGTP CGPGHLCSEG SCLPEEEVER PKPVADGGWA PWGPWGECSR 
       550        560        570        580        590        600 
TCGGGVQFSH RECKDPEPQN GGRYCLGRRA KYQSCHTEEC PPDGKSFREQ QCEKYNAYNY 
       610        620        630        640        650        660 
TDMDGNLLQW VPKYAGVSPR DRCKLFCRAR GRSEFKVFEA KVIDGTLCGP ETLAICVRGQ 
       670        680        690        700        710        720 
CVKAGCDHVV DSPRKLDKCG VCGGKGNSCR KVSGSLTPTN YGYNDIVTIP AGATNIDVKQ 
       730        740        750        760        770        780 
RSHPGVQNDG NYLALKTADG QYLLNGNLAI SAIEQDILVK GTILKYSGSI ATLERLQSFR 
       790        800        810        820        830        840 
PLPEPLTVQL LTVPGEVFPP KVKYTFFVPN DVDFSMQSSK ERATTNIIQP LLHAQWVLGD 
       850        860        870        880    
WSECSSTCGA GWQRRTVECR DPSGQASATC NKALKPEDAK PCESQLCPL

Isoforms



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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 3 Substrates

N-termini

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...QLCPL 889 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates