TopFIND 4.0

Q9WVF7: DNA polymerase epsilon catalytic subunit A

General Information

Protein names
- DNA polymerase epsilon catalytic subunit A
- 2.7.7.7
- DNA polymerase II subunit A
Gene names Pole
Organism Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID Q9WVF7

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MVLRNSGRRH PEPGADGEGS RDDGPSSSVS ALKRLERSQW TDKMDLRFGF ERLKEPGERT 
        70         80         90        100        110        120 
GWLINMHPTE ILDEDKRLVS AVDYYFIQDD GSRFKVALPY MPYFYIAARK GCDREVSSFL 
       130        140        150        160        170        180 
SKKFQGKIAK LENVPKEDLD LPNHLVGLKR SYIKLSFHTV EDLVKVRKEI SPAVKKNREQ 
       190        200        210        220        230        240 
DHASDEYTTM LSSILQGGSV ITDEDETSKK IADQLDNIVD MREYDVPYHI RLSIDLRIHV 
       250        260        270        280        290        300 
AHWYNVRFRG NAFPVEITRR DDLVERPDPV VLAFDIETTK LPLKFPDAET DQIMMISYMI 
       310        320        330        340        350        360 
DGQGYLITNR EIVSEDIEDF EFTPKPEYEG PFCVFNEPDE VHLIQRWFEH IQETKPTIMV 
       370        380        390        400        410        420 
TYNGDFFDWP FVEARAAIHG LSMYQEIGFQ KDSQGEYKAP QCIHMDCLRW VKRDSYLPVG 
       430        440        450        460        470        480 
SHNLKAAAKA KLGYDPVELD PEDMCRMATE QPQTLATYSV SDAVATYYLY MKYVHPFIFA 
       490        500        510        520        530        540 
LCTIIPMEPD EVLRKGSGTL CEALLMVQAF HANIIFPNKQ EQEFNKLTDD GHMLDAETYV 
       550        560        570        580        590        600 
GGHVEALESG VFRSDIPCRF RMNPAAFDFL LQRVEKTMRH AIEEEEKVPV EQATNFQEVC 
       610        620        630        640        650        660 
EQIKTKLTSL KDVPNRIECP LIYHLDVGAM YPNIILTNRL QPSAIVDEAT CAACDFNKPG 
       670        680        690        700        710        720 
ASCQRKMAWQ WRGEFMPASR SEYHRIQHQL ESEKFPPLFP EGPARAFHEL SREEQAKYEK 
       730        740        750        760        770        780 
RRLADYCRKA YKKIHVTKVE ERLTTICQRE NSFYVDTVRA FRDRRYEFKG LHKVWKKKLS 
       790        800        810        820        830        840 
AAVEVGDASE VKRCKNMEIL YDSLQLAHKC ILNSFYGYVM RKGARWYSME MAGIVCFTGA 
       850        860        870        880        890        900 
NIITQARELI EQIGRPLELD TDGIWCVLPN SFPENFVIKT TNAKKPKLTI SYPGAMLNIM 
       910        920        930        940        950        960 
VKEGFTNHQY QELTEPSSLT YVTHSENSIF FEVDGPYLAM ILPASKEEGK KLKKRYAVFN 
       970        980        990       1000       1010       1020 
EDGSLAELKG FEVKRRGELQ LIKIFQSSVF EAFLKGSTLE EVYGSVAKVA DYWLDVLYSK 
      1030       1040       1050       1060       1070       1080 
AANMPDSELF ELISENRSMS RKLEDYGEQK STSISTAKRL AEFLGDQMVK DAGLSCRYII 
      1090       1100       1110       1120       1130       1140 
SRKPEGSPVT ERAIPLAIFQ AEPTVRKHFL RKWLKSSSLQ DFDIRTILDW DYYIERLGSA 
      1150       1160       1170       1180       1190       1200 
IQKIITIPAA LQQVKNPVPR VKHPDWLHKK LLEKNDIYKQ KKISELFVLE GKRQIVMAQA 
      1210       1220       1230       1240       1250       1260 
SENSLSLCTP DMEDIGLTKP HHSTVPVATK RKRVWETQKE SQDIALTVPW QEVLGQPPSL 
      1270       1280       1290       1300       1310       1320 
GTTQEEWLVW LQFHKKKWQL QAQQRLALRK KQRLESAEDM PRLGPIREGP STGLGSFLRR 
      1330       1340       1350       1360       1370       1380 
TARSIMDLPW QIIQISETRQ AGLFRLWAII GNDLHCIKLS IPRVFYVNQR VAKAEDGPAY 
      1390       1400       1410       1420       1430       1440 
RKVNRALPRS NIVYNLYEYS VPEDMYQEHI NEINTELSVP DIEGVYETQV PLLFRALVQL 
      1450       1460       1470       1480       1490       1500 
GCVCVVNKQL TRHLSGWEAE TFALEHLEMR SLAQFSYLEP GSIRHIYLYH HTQGHKALFG 
      1510       1520       1530       1540       1550       1560 
VFIPSQRRAS VFVLDTVRSN QMPGLSALYS SEHSLLLDKV DPKLLPPPKH TFEVRAETNL 
      1570       1580       1590       1600       1610       1620 
KTICRAIQRF LLAYKEERRG PTLIAVQSSW ELCRLTSEIP VLEEFPLVPI RVADKISYAV 
      1630       1640       1650       1660       1670       1680 
LDWQRHGARR MIRHYLNLDL CLSQAFEMSR YFHIPVGNLP EDISTFGSDL FFARHLQHHN 
      1690       1700       1710       1720       1730       1740 
HLLWLSPTSR PDLGGKEADD NRLVMEFDDR ATVEINSSGC YSTVCVELDI QNLAVNTILQ 
      1750       1760       1770       1780       1790       1800 
SHHVNDMEGA GSMGISFDVI QQASLEDMVT GNQAASALAN YDETALCSST FRILKSMVVG 
      1810       1820       1830       1840       1850       1860 
WVKEITQYHN IYADNQVMHF YRWLQSPCSL LHDPALHRTL HNMMKKLFLQ LIAEFKRLGS 
      1870       1880       1890       1900       1910       1920 
SVVYANFNRI ILCTKKRRIE DALAYVEYIT NSIHSKEIFH SLTISFSRCW EFLLWMDPSN 
      1930       1940       1950       1960       1970       1980 
YGGIKGKVPS SIHCGQVKEQ DSQAREETDE EEEDKEKDEE EEGMGESEVE DLLENNWNIL 
      1990       2000       2010       2020       2030       2040 
QFLPQAASCQ SYFLMIVSAY IVAVYQSMKE ELRHSAPGST PVKRKGASQF SQESEGATGS 
      2050       2060       2070       2080       2090       2100 
LPGMITFSQD YVANELTQSF FTITQKIQKK VTGSRNTTEP SEMFPVLPGS HLLLNNPALE 
      2110       2120       2130       2140       2150       2160 
FIKYVCKVLS LDTNITNQVN KLNRDLLRLV DVGEFSEEAQ FRDPCHSYVL PEVICHSCNF 
      2170       2180       2190       2200       2210       2220 
CRDLDLCKDS SFSQDGAILP QWLCSNCQAP YDSSAIESAL VEALQRKLMA FTLQDLVCLK 
      2230       2240       2250       2260       2270       2280 
CRGMKETHMP VYCSCAGDFT LTIRTEVFME QIRIFQNIAK YYSMSYLQET IEWLLQTSPV 
   
SNC

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q9WVF7-1-unknown MVLRNS... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...PVSNC 2283 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)