TopFIND 4.0

Q9WVS7: Dual specificity mitogen-activated protein kinase kinase 5

General Information

Protein names
- Dual specificity mitogen-activated protein kinase kinase 5
- MAP kinase kinase 5
- MAPKK 5
- 2.7.12.2
- MAPK/ERK kinase 5
- MEK 5
Gene names Map2k5
Organism Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID Q9WVS7

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MLWLALGPFC AMENQVLVIR IKIPNSGAVD WTVHSGPQLL FRDVLDVIGQ VLPEATTTAF 
        70         80         90        100        110        120 
EYEDEDGDRI TVRSDEEMKA MLSYYYSTVM EQQVNGQLIE PLQIFPRACK PPGERNIHGL 
       130        140        150        160        170        180 
KVNTRAGPSQ HTSPVVSDSL PSNSLKKSSA ELRKILANGQ MNEQDIRYRD TLGHGNGGTV 
       190        200        210        220        230        240 
YKAHHVPSGK ILAVKVILLD ITLELQKQIM SELEILYKCD SSYIIGFYGA FFVENRISIC 
       250        260        270        280        290        300 
TEFMDGGSLD VYRKIPEHVL GRIAVAVVKG LTYLWSLKIL HRDVKPSNML VNTGGQVKLC 
       310        320        330        340        350        360 
DFGVSTQLVN SIAKTYVGTN AYMAPERISG EQYGIHSDVW SLGISFMELA LGRFPYPQIQ 
       370        380        390        400        410        420 
KNQGSLMPLQ LLQCIVDEDS PVLPLGEFSE PFVHFITQCM RKQPKERPAP EELMGHPFIV 
       430        440    
QFNDGNSTVV SMWVCRALEE RRSQQGPP

Isoforms

- Isoform 2 of Dual specificity mitogen-activated protein kinase kinase 5 - Isoform 3 of Dual specificity mitogen-activated protein kinase kinase 5 - Isoform 4 of Dual specificity mitogen-activated protein kinase kinase 5

Sequence View

        10         20         30         40         50         60 
MLWLALGPFC AMENQVLVIR IKIPNSGAVD WTVHSGPQLL FRDVLDVIGQ VLPEATTTAF 
        70         80         90        100        110        120 
EYEDEDGDRI TVRSDEEMKA MLSYYYSTVM EQQVNGQLIE PLQIFPRACK PPGERNIHGL 
       130        140        150        160        170        180 
KVNTRAGPSQ HTSPVVSDSL PSNSLKKSSA ELRKILANGQ MNEQDIRYRD TLGHGNGGTV 
       190        200        210        220        230        240 
YKAHHVPSGK ILAVKVILLD ITLELQKQIM SELEILYKCD SSYIIGFYGA FFVENRISIC 
       250        260        270        280        290        300 
TEFMDGGSLD VYRKIPEHVL GRIAVAVVKG LTYLWSLKIL HRDVKPSNML VNTGGQVKLC 
       310        320        330        340        350        360 
DFGVSTQLVN SIAKTYVGTN AYMAPERISG EQYGIHSDVW SLGISFMELA LGRFPYPQIQ 
       370        380        390        400        410        420 
KNQGSLMPLQ LLQCIVDEDS PVLPLGEFSE PFVHFITQCM RKQPKERPAP EELMGHPFIV 
       430        440    
QFNDGNSTVV SMWVCRALEE RRSQQGPP         10         20         30         40         50         60 
MLWLALGPFC AMENQVLVIR IKIPNSGAVD WTVHSGPQLL FRDVLDVIGQ VLPEATTTAF 
        70         80         90        100        110        120 
EYEDEDGDRI TVRSDEEMKA MLSYYYSTVM EQQVNGQLIE PLQIFPRACK PPGERNIHGL 
       130        140        150        160        170        180 
KVNTRAGPSQ HTSPVVSDSL PSNSLKKSSA ELRKILANGQ MNEQDIRYRD TLGHGNGGTV 
       190        200        210        220        230        240 
YKAHHVPSGK ILAVKVILLD ITLELQKQIM SELEILYKCD SSYIIGFYGA FFVENRISIC 
       250        260        270        280        290        300 
TEFMDGGSLD VYRKIPEHVL GRIAVAVVKG LTYLWSLKIL HRDVKPSNML VNTGGQVKLC 
       310        320        330        340        350        360 
DFGVSTQLVN SIAKTYVGTN AYMAPERISG EQYGIHSDVW SLGISFMELA LGRFPYPQIQ 
       370        380        390        400        410        420 
KNQGSLMPLQ LLQCIVDEDS PVLPLGEFSE PFVHFITQCM RKQPKERPAP EELMGHPFIV 
       430        440    
QFNDGNSTVV SMWVCRALEE RRSQQGPP         10         20         30         40         50         60 
MLWLALGPFC AMENQVLVIR IKIPNSGAVD WTVHSGPQLL FRDVLDVIGQ VLPEATTTAF 
        70         80         90        100        110        120 
EYEDEDGDRI TVRSDEEMKA MLSYYYSTVM EQQVNGQLIE PLQIFPRACK PPGERNIHGL 
       130        140        150        160        170        180 
KVNTRAGPSQ HTSPVVSDSL PSNSLKKSSA ELRKILANGQ MNEQDIRYRD TLGHGNGGTV 
       190        200        210        220        230        240 
YKAHHVPSGK ILAVKVILLD ITLELQKQIM SELEILYKCD SSYIIGFYGA FFVENRISIC 
       250        260        270        280        290        300 
TEFMDGGSLD VYRKIPEHVL GRIAVAVVKG LTYLWSLKIL HRDVKPSNML VNTGGQVKLC 
       310        320        330        340        350        360 
DFGVSTQLVN SIAKTYVGTN AYMAPERISG EQYGIHSDVW SLGISFMELA LGRFPYPQIQ 
       370        380        390        400        410        420 
KNQGSLMPLQ LLQCIVDEDS PVLPLGEFSE PFVHFITQCM RKQPKERPAP EELMGHPFIV 
       430        440    
QFNDGNSTVV SMWVCRALEE RRSQQGPP



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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...QQGPP 448 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...QQGPP 448 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt77050

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)