Q9Y250: Leucine zipper putative tumor suppressor 1

General Information

Protein names	- Leucine zipper putative tumor suppressor 1 - F37/esophageal cancer-related gene-coding leucine-zipper motif - Fez1
Gene names	LZTS1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9Y250

2 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Leucine zipper putative tumor suppressor 1 - Isoform 3 of Leucine zipper putative tumor suppressor 1 - Isoform 4 of Leucine zipper putative tumor suppressor 1 - Isoform 5 of Leucine zipper putative tumor suppressor 1 - Isoform 6 of Leucine zipper putative tumor suppressor 1 - Isoform 7 of Leucine zipper putative tumor suppressor 1

Sequence View

        10         20         30         40         50         60
MGSVSSLISG HSFHSKHCRA SQYKLRKSSH LKKLNRYSDG LLRFGFSQDS GHGKSSSKMG
        70         80         90        100        110        120
KSEDFFYIKV SQKARGSHHP DYTALSSGDL GGQAGVDFDP STPPKLMPFS NQLEMGSEKG
       130        140        150        160        170        180
AVRPTAFKPV LPRSGAILHS SPESASHQLH PAPPDKPKEQ ELKPGLCSGA LSDSGRNSMS
       190        200        210        220        230        240
SLPTHSTSSS YQLDPLVTPV GPTSRFGGSA HNITQGIVLQ DSNMMSLKAL SFSDGGSKLG
       250        260        270        280        290        300
HSNKADKGPS CVRSPISTDE CSIQELEQKL LEREGALQKL QRSFEEKELA SSLAYEERPR
       310        320        330        340        350        360
RCRDELEGPE PKGGNKLKQA SQKSQRAQQV LHLQVLQLQQ EKRQLRQELE SLMKEQDLLE
       370        380        390        400        410        420
TKLRSYEREK TSFGPALEET QWEVCQKSGE ISLLKQQLKE SQTEVNAKAS EILGLKAQLK
       430        440        450        460        470        480
DTRGKLEGLE LRTQDLEGAL RTKGLELEVC ENELQRKKNE AELLREKVNL LEQELQELRA
       490        500        510        520        530        540
QAALARDMGP PTFPEDVPAL QRELERLRAE LREERQGHDQ MSSGFQHERL VWKEEKEKVI
       550        560        570        580        590
QYQKQLQQSY VAMYQRNQRL EKALQQLARG DSAGEPLEVD LEGADIPYED IIATEI         10         20         30         40         50         60
MGSVSSLISG HSFHSKHCRA SQYKLRKSSH LKKLNRYSDG LLRFGFSQDS GHGKSSSKMG
        70         80         90        100        110        120
KSEDFFYIKV SQKARGSHHP DYTALSSGDL GGQAGVDFDP STPPKLMPFS NQLEMGSEKG
       130        140        150        160        170        180
AVRPTAFKPV LPRSGAILHS SPESASHQLH PAPPDKPKEQ ELKPGLCSGA LSDSGRNSMS
       190        200        210        220        230        240
SLPTHSTSSS YQLDPLVTPV GPTSRFGGSA HNITQGIVLQ DSNMMSLKAL SFSDGGSKLG
       250        260        270        280        290        300
HSNKADKGPS CVRSPISTDE CSIQELEQKL LEREGALQKL QRSFEEKELA SSLAYEERPR
       310        320        330        340        350        360
RCRDELEGPE PKGGNKLKQA SQKSQRAQQV LHLQVLQLQQ EKRQLRQELE SLMKEQDLLE
       370        380        390        400        410        420
TKLRSYEREK TSFGPALEET QWEVCQKSGE ISLLKQQLKE SQTEVNAKAS EILGLKAQLK
       430        440        450        460        470        480
DTRGKLEGLE LRTQDLEGAL RTKGLELEVC ENELQRKKNE AELLREKVNL LEQELQELRA
       490        500        510        520        530        540
QAALARDMGP PTFPEDVPAL QRELERLRAE LREERQGHDQ MSSGFQHERL VWKEEKEKVI
       550        560        570        580        590
QYQKQLQQSY VAMYQRNQRL EKALQQLARG DSAGEPLEVD LEGADIPYED IIATEI         10         20         30         40         50         60
MGSVSSLISG HSFHSKHCRA SQYKLRKSSH LKKLNRYSDG LLRFGFSQDS GHGKSSSKMG
        70         80         90        100        110        120
KSEDFFYIKV SQKARGSHHP DYTALSSGDL GGQAGVDFDP STPPKLMPFS NQLEMGSEKG
       130        140        150        160        170        180
AVRPTAFKPV LPRSGAILHS SPESASHQLH PAPPDKPKEQ ELKPGLCSGA LSDSGRNSMS
       190        200        210        220        230        240
SLPTHSTSSS YQLDPLVTPV GPTSRFGGSA HNITQGIVLQ DSNMMSLKAL SFSDGGSKLG
       250        260        270        280        290        300
HSNKADKGPS CVRSPISTDE CSIQELEQKL LEREGALQKL QRSFEEKELA SSLAYEERPR
       310        320        330        340        350        360
RCRDELEGPE PKGGNKLKQA SQKSQRAQQV LHLQVLQLQQ EKRQLRQELE SLMKEQDLLE
       370        380        390        400        410        420
TKLRSYEREK TSFGPALEET QWEVCQKSGE ISLLKQQLKE SQTEVNAKAS EILGLKAQLK
       430        440        450        460        470        480
DTRGKLEGLE LRTQDLEGAL RTKGLELEVC ENELQRKKNE AELLREKVNL LEQELQELRA
       490        500        510        520        530        540
QAALARDMGP PTFPEDVPAL QRELERLRAE LREERQGHDQ MSSGFQHERL VWKEEKEKVI
       550        560        570        580        590
QYQKQLQQSY VAMYQRNQRL EKALQQLARG DSAGEPLEVD LEGADIPYED IIATEI         10         20         30         40         50         60
MGSVSSLISG HSFHSKHCRA SQYKLRKSSH LKKLNRYSDG LLRFGFSQDS GHGKSSSKMG
        70         80         90        100        110        120
KSEDFFYIKV SQKARGSHHP DYTALSSGDL GGQAGVDFDP STPPKLMPFS NQLEMGSEKG
       130        140        150        160        170        180
AVRPTAFKPV LPRSGAILHS SPESASHQLH PAPPDKPKEQ ELKPGLCSGA LSDSGRNSMS
       190        200        210        220        230        240
SLPTHSTSSS YQLDPLVTPV GPTSRFGGSA HNITQGIVLQ DSNMMSLKAL SFSDGGSKLG
       250        260        270        280        290        300
HSNKADKGPS CVRSPISTDE CSIQELEQKL LEREGALQKL QRSFEEKELA SSLAYEERPR
       310        320        330        340        350        360
RCRDELEGPE PKGGNKLKQA SQKSQRAQQV LHLQVLQLQQ EKRQLRQELE SLMKEQDLLE
       370        380        390        400        410        420
TKLRSYEREK TSFGPALEET QWEVCQKSGE ISLLKQQLKE SQTEVNAKAS EILGLKAQLK
       430        440        450        460        470        480
DTRGKLEGLE LRTQDLEGAL RTKGLELEVC ENELQRKKNE AELLREKVNL LEQELQELRA
       490        500        510        520        530        540
QAALARDMGP PTFPEDVPAL QRELERLRAE LREERQGHDQ MSSGFQHERL VWKEEKEKVI
       550        560        570        580        590
QYQKQLQQSY VAMYQRNQRL EKALQQLARG DSAGEPLEVD LEGADIPYED IIATEI         10         20         30         40         50         60
MGSVSSLISG HSFHSKHCRA SQYKLRKSSH LKKLNRYSDG LLRFGFSQDS GHGKSSSKMG
        70         80         90        100        110        120
KSEDFFYIKV SQKARGSHHP DYTALSSGDL GGQAGVDFDP STPPKLMPFS NQLEMGSEKG
       130        140        150        160        170        180
AVRPTAFKPV LPRSGAILHS SPESASHQLH PAPPDKPKEQ ELKPGLCSGA LSDSGRNSMS
       190        200        210        220        230        240
SLPTHSTSSS YQLDPLVTPV GPTSRFGGSA HNITQGIVLQ DSNMMSLKAL SFSDGGSKLG
       250        260        270        280        290        300
HSNKADKGPS CVRSPISTDE CSIQELEQKL LEREGALQKL QRSFEEKELA SSLAYEERPR
       310        320        330        340        350        360
RCRDELEGPE PKGGNKLKQA SQKSQRAQQV LHLQVLQLQQ EKRQLRQELE SLMKEQDLLE
       370        380        390        400        410        420
TKLRSYEREK TSFGPALEET QWEVCQKSGE ISLLKQQLKE SQTEVNAKAS EILGLKAQLK
       430        440        450        460        470        480
DTRGKLEGLE LRTQDLEGAL RTKGLELEVC ENELQRKKNE AELLREKVNL LEQELQELRA
       490        500        510        520        530        540
QAALARDMGP PTFPEDVPAL QRELERLRAE LREERQGHDQ MSSGFQHERL VWKEEKEKVI
       550        560        570        580        590
QYQKQLQQSY VAMYQRNQRL EKALQQLARG DSAGEPLEVD LEGADIPYED IIATEI         10         20         30         40         50         60
MGSVSSLISG HSFHSKHCRA SQYKLRKSSH LKKLNRYSDG LLRFGFSQDS GHGKSSSKMG
        70         80         90        100        110        120
KSEDFFYIKV SQKARGSHHP DYTALSSGDL GGQAGVDFDP STPPKLMPFS NQLEMGSEKG
       130        140        150        160        170        180
AVRPTAFKPV LPRSGAILHS SPESASHQLH PAPPDKPKEQ ELKPGLCSGA LSDSGRNSMS
       190        200        210        220        230        240
SLPTHSTSSS YQLDPLVTPV GPTSRFGGSA HNITQGIVLQ DSNMMSLKAL SFSDGGSKLG
       250        260        270        280        290        300
HSNKADKGPS CVRSPISTDE CSIQELEQKL LEREGALQKL QRSFEEKELA SSLAYEERPR
       310        320        330        340        350        360
RCRDELEGPE PKGGNKLKQA SQKSQRAQQV LHLQVLQLQQ EKRQLRQELE SLMKEQDLLE
       370        380        390        400        410        420
TKLRSYEREK TSFGPALEET QWEVCQKSGE ISLLKQQLKE SQTEVNAKAS EILGLKAQLK
       430        440        450        460        470        480
DTRGKLEGLE LRTQDLEGAL RTKGLELEVC ENELQRKKNE AELLREKVNL LEQELQELRA
       490        500        510        520        530        540
QAALARDMGP PTFPEDVPAL QRELERLRAE LREERQGHDQ MSSGFQHERL VWKEEKEKVI
       550        560        570        580        590
QYQKQLQQSY VAMYQRNQRL EKALQQLARG DSAGEPLEVD LEGADIPYED IIATEI

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9Y250-1-unknown	MGSVSS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80132
Q9Y250-1-unknown	MGSVSS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80133
Q9Y250-1-unknown	MGSVSS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80134
Q9Y250-1-unknown	MGSVSS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80135
Q9Y250-1-unknown	MGSVSS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80136
Q9Y250-1-unknown	MGSVSS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80137
Q9Y250-2-unknown	GSVSSL...	2	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9Y250-2-unknown	GSVSSL...	2	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
Q9Y250-2-unknown	GSVSSL...	2	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111426
Q9Y250-2-unknown	GSVSSL...	2	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111427
Q9Y250-2-unknown	GSVSSL...	2	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111428
Q9Y250-2-unknown	GSVSSL...	2	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111429
Q9Y250-2-unknown	GSVSSL...	2	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111430
Q9Y250-2-unknown	GSVSSL...	2	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111431

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...IATEI	596	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...IATEI	596	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75754
...IATEI	596	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75753
...IATEI	596	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75752
...IATEI	596	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75751
...IATEI	596	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75750

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)