TopFIND 4.0

Q9Y2E8: Sodium/hydrogen exchanger 8

General Information

Protein names
- Sodium/hydrogen exchanger 8
- Na(+)/H(+) exchanger 8
- NHE-8
- Solute carrier family 9 member 8
Gene names SLC9A8
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q9Y2E8

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MGEKMAEEER FPNTTHEGFN VTLHTTLVVT TKLVLPTPGK PILPVQTGEQ AQQEEQSSGM 
        70         80         90        100        110        120 
TIFFSLLVLA ICIILVHLLI RYRLHFLPES VAVVSLGILM GAVIKIIEFK KLANWKEEEM 
       130        140        150        160        170        180 
FRPNMFFLLL LPPIIFESGY SLHKGNFFQN IGSITLFAVF GTAISAFVVG GGIYFLGQAD 
       190        200        210        220        230        240 
VISKLNMTDS FAFGSLISAV DPVATIAIFN ALHVDPVLNM LVFGESILND AVSIVLTNTA 
       250        260        270        280        290        300 
EGLTRKNMSD VSGWQTFLQA LDYFLKMFFG SAALGTLTGL ISALVLKHID LRKTPSLEFG 
       310        320        330        340        350        360 
MMIIFAYLPY GLAEGISLSG IMAILFSGIV MSHYTHHNLS PVTQILMQQT LRTVAFLCET 
       370        380        390        400        410        420 
CVFAFLGLSI FSFPHKFEIS FVIWCIVLVL FGRAVNIFPL SYLLNFFRDH KITPKMMFIM 
       430        440        450        460        470        480 
WFSGLRGAIP YALSLHLDLE PMEKRQLIGT TTIVIVLFTI LLLGGSTMPL IRLMDIEDAK 
       490        500        510        520        530        540 
AHRRNKKDVN LSKTEKMGNT VESEHLSELT EEEYEAHYIR RQDLKGFVWL DAKYLNPFFT 
       550        560        570        580    
RRLTQEDLHH GRIQMKTLTN KWYEEVRQGP SGSEDDEQEL L

Isoforms

- Isoform 2 of Sodium/hydrogen exchanger 8

Sequence View

        10         20         30         40         50         60 
MGEKMAEEER FPNTTHEGFN VTLHTTLVVT TKLVLPTPGK PILPVQTGEQ AQQEEQSSGM 
        70         80         90        100        110        120 
TIFFSLLVLA ICIILVHLLI RYRLHFLPES VAVVSLGILM GAVIKIIEFK KLANWKEEEM 
       130        140        150        160        170        180 
FRPNMFFLLL LPPIIFESGY SLHKGNFFQN IGSITLFAVF GTAISAFVVG GGIYFLGQAD 
       190        200        210        220        230        240 
VISKLNMTDS FAFGSLISAV DPVATIAIFN ALHVDPVLNM LVFGESILND AVSIVLTNTA 
       250        260        270        280        290        300 
EGLTRKNMSD VSGWQTFLQA LDYFLKMFFG SAALGTLTGL ISALVLKHID LRKTPSLEFG 
       310        320        330        340        350        360 
MMIIFAYLPY GLAEGISLSG IMAILFSGIV MSHYTHHNLS PVTQILMQQT LRTVAFLCET 
       370        380        390        400        410        420 
CVFAFLGLSI FSFPHKFEIS FVIWCIVLVL FGRAVNIFPL SYLLNFFRDH KITPKMMFIM 
       430        440        450        460        470        480 
WFSGLRGAIP YALSLHLDLE PMEKRQLIGT TTIVIVLFTI LLLGGSTMPL IRLMDIEDAK 
       490        500        510        520        530        540 
AHRRNKKDVN LSKTEKMGNT VESEHLSELT EEEYEAHYIR RQDLKGFVWL DAKYLNPFFT 
       550        560        570        580    
RRLTQEDLHH GRIQMKTLTN KWYEEVRQGP SGSEDDEQEL L



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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q9Y2E8-1-unknown MGEKMA... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q9Y2E8-1-unknown MGEKMA... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt89883

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...EQELL 581 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...EQELL 581 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt85501

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)