TopFIND 4.0

Q9Y2G2: Caspase recruitment domain-containing protein 8

General Information

Protein names
- Caspase recruitment domain-containing protein 8
- Apoptotic protein NDPP1
- CARD-inhibitor of NF-kappa-B-activating ligand
- CARDINAL
- DACAR
- Tumor up-regulated CARD-containing antagonist of CASP9
- TUCAN
Gene names CARD8
Organism Homo sapiens
Protease Family S79.001
Protease ID S79.001
Chromosome location
UniProt ID Q9Y2G2

2

N-termini

2

C-termini

1

Cleavages

5

Substrates

Sequence

        10         20         30         40         50         60 
MMRQRQSHYC SVLFLSVNYL GGTFPGDICS EENQIVSSYA SKVCFEIEED YKNRQFLGPE 
        70         80         90        100        110        120 
GNVDVELIDK STNRYSVWFP TAGWYLWSAT GLGFLVRDEV TVTIAFGSWS QHLALDLQHH 
       130        140        150        160        170        180 
EQWLVGGPLF DVTAEPEEAV AEIHLPHFIS LQGEVDVSWF LVAHFKNEGM VLEHPARVEP 
       190        200        210        220        230        240 
FYAVLESPSF SLMGILLRIA SGTRLSIPIT SNTLIYYHPH PEDIKFHLYL VPSDALLTKA 
       250        260        270        280        290        300 
IDDEEDRFHG VRLQTSPPME PLNFGSSYIV SNSANLKVMP KELKLSYRSP GEIQHFSKFY 
       310        320        330        340        350        360 
AGQMKEPIQL EITEKRHGTL VWDTEVKPVD LQLVAASAPP PFSGAAFVKE NHRQLQARMG 
       370        380        390        400        410        420 
DLKGVLDDLQ DNEVLTENEK ELVEQEKTRQ SKNEALLSMV EKKGDLALDV LFRSISERDP 
       430    
YLVSYLRQQN L

Isoforms

- Isoform 2 of Caspase recruitment domain-containing protein 8 - Isoform 3 of Caspase recruitment domain-containing protein 8 - Isoform 4 of Caspase recruitment domain-containing protein 8 - Isoform 5 of Caspase recruitment domain-containing protein 8

Sequence View

        10         20         30         40         50         60 
MMRQRQSHYC SVLFLSVNYL GGTFPGDICS EENQIVSSYA SKVCFEIEED YKNRQFLGPE 
        70         80         90        100        110        120 
GNVDVELIDK STNRYSVWFP TAGWYLWSAT GLGFLVRDEV TVTIAFGSWS QHLALDLQHH 
       130        140        150        160        170        180 
EQWLVGGPLF DVTAEPEEAV AEIHLPHFIS LQGEVDVSWF LVAHFKNEGM VLEHPARVEP 
       190        200        210        220        230        240 
FYAVLESPSF SLMGILLRIA SGTRLSIPIT SNTLIYYHPH PEDIKFHLYL VPSDALLTKA 
       250        260        270        280        290        300 
IDDEEDRFHG VRLQTSPPME PLNFGSSYIV SNSANLKVMP KELKLSYRSP GEIQHFSKFY 
       310        320        330        340        350        360 
AGQMKEPIQL EITEKRHGTL VWDTEVKPVD LQLVAASAPP PFSGAAFVKE NHRQLQARMG 
       370        380        390        400        410        420 
DLKGVLDDLQ DNEVLTENEK ELVEQEKTRQ SKNEALLSMV EKKGDLALDV LFRSISERDP 
       430    
YLVSYLRQQN L         10         20         30         40         50         60 
MMRQRQSHYC SVLFLSVNYL GGTFPGDICS EENQIVSSYA SKVCFEIEED YKNRQFLGPE 
        70         80         90        100        110        120 
GNVDVELIDK STNRYSVWFP TAGWYLWSAT GLGFLVRDEV TVTIAFGSWS QHLALDLQHH 
       130        140        150        160        170        180 
EQWLVGGPLF DVTAEPEEAV AEIHLPHFIS LQGEVDVSWF LVAHFKNEGM VLEHPARVEP 
       190        200        210        220        230        240 
FYAVLESPSF SLMGILLRIA SGTRLSIPIT SNTLIYYHPH PEDIKFHLYL VPSDALLTKA 
       250        260        270        280        290        300 
IDDEEDRFHG VRLQTSPPME PLNFGSSYIV SNSANLKVMP KELKLSYRSP GEIQHFSKFY 
       310        320        330        340        350        360 
AGQMKEPIQL EITEKRHGTL VWDTEVKPVD LQLVAASAPP PFSGAAFVKE NHRQLQARMG 
       370        380        390        400        410        420 
DLKGVLDDLQ DNEVLTENEK ELVEQEKTRQ SKNEALLSMV EKKGDLALDV LFRSISERDP 
       430    
YLVSYLRQQN L         10         20         30         40         50         60 
MMRQRQSHYC SVLFLSVNYL GGTFPGDICS EENQIVSSYA SKVCFEIEED YKNRQFLGPE 
        70         80         90        100        110        120 
GNVDVELIDK STNRYSVWFP TAGWYLWSAT GLGFLVRDEV TVTIAFGSWS QHLALDLQHH 
       130        140        150        160        170        180 
EQWLVGGPLF DVTAEPEEAV AEIHLPHFIS LQGEVDVSWF LVAHFKNEGM VLEHPARVEP 
       190        200        210        220        230        240 
FYAVLESPSF SLMGILLRIA SGTRLSIPIT SNTLIYYHPH PEDIKFHLYL VPSDALLTKA 
       250        260        270        280        290        300 
IDDEEDRFHG VRLQTSPPME PLNFGSSYIV SNSANLKVMP KELKLSYRSP GEIQHFSKFY 
       310        320        330        340        350        360 
AGQMKEPIQL EITEKRHGTL VWDTEVKPVD LQLVAASAPP PFSGAAFVKE NHRQLQARMG 
       370        380        390        400        410        420 
DLKGVLDDLQ DNEVLTENEK ELVEQEKTRQ SKNEALLSMV EKKGDLALDV LFRSISERDP 
       430    
YLVSYLRQQN L         10         20         30         40         50         60 
MMRQRQSHYC SVLFLSVNYL GGTFPGDICS EENQIVSSYA SKVCFEIEED YKNRQFLGPE 
        70         80         90        100        110        120 
GNVDVELIDK STNRYSVWFP TAGWYLWSAT GLGFLVRDEV TVTIAFGSWS QHLALDLQHH 
       130        140        150        160        170        180 
EQWLVGGPLF DVTAEPEEAV AEIHLPHFIS LQGEVDVSWF LVAHFKNEGM VLEHPARVEP 
       190        200        210        220        230        240 
FYAVLESPSF SLMGILLRIA SGTRLSIPIT SNTLIYYHPH PEDIKFHLYL VPSDALLTKA 
       250        260        270        280        290        300 
IDDEEDRFHG VRLQTSPPME PLNFGSSYIV SNSANLKVMP KELKLSYRSP GEIQHFSKFY 
       310        320        330        340        350        360 
AGQMKEPIQL EITEKRHGTL VWDTEVKPVD LQLVAASAPP PFSGAAFVKE NHRQLQARMG 
       370        380        390        400        410        420 
DLKGVLDDLQ DNEVLTENEK ELVEQEKTRQ SKNEALLSMV EKKGDLALDV LFRSISERDP 
       430    
YLVSYLRQQN L



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


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Protease Assignment Confidence:


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Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 1 Cleavages - 5 Substrates

N-termini

C-termini

Cleavages

Substrates