Q9Y3Z3: Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 {ECO:0000305}

General Information

Protein names	- Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 {ECO:0000305} - dNTPase {ECO:0000305} - 3.1.5.- {ECO:0000269\|PubMed:22056990, ECO:0000269\|PubMed:23601106, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:26101257, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200} - Dendritic cell-derived IFNG-induced protein {ECO:0000303\|PubMed:11064105} - DCIP {ECO:0000303\|PubMed:11064105} - Monocyte protein 5 {ECO:0000303\|Ref.2} - MOP-5 {ECO:0000303\|Ref.2} - SAM domain and HD domain-containing protein 1 {ECO:0000305} - hSAMHD1 {ECO:0000303\|PubMed:29379009}
Gene names	SAMHD1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9Y3Z3

2 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 - Isoform 3 of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 - Isoform 4 of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

Sequence View

        10         20         30         40         50         60
MQRADSEQPS KRPRCDDSPR TPSNTPSAEA DWSPGLELHP DYKTWGPEQV CSFLRRGGFE
        70         80         90        100        110        120
EPVLLKNIRE NEITGALLPC LDESRFENLG VSSLGERKKL LSYIQRLVQI HVDTMKVIND
       130        140        150        160        170        180
PIHGHIELHP LLVRIIDTPQ FQRLRYIKQL GGGYYVFPGA SHNRFEHSLG VGYLAGCLVH
       190        200        210        220        230        240
ALGEKQPELQ ISERDVLCVQ IAGLCHDLGH GPFSHMFDGR FIPLARPEVK WTHEQGSVMM
       250        260        270        280        290        300
FEHLINSNGI KPVMEQYGLI PEEDICFIKE QIVGPLESPV EDSLWPYKGR PENKSFLYEI
       310        320        330        340        350        360
VSNKRNGIDV DKWDYFARDC HHLGIQNNFD YKRFIKFARV CEVDNELRIC ARDKEVGNLY
       370        380        390        400        410        420
DMFHTRNSLH RRAYQHKVGN IIDTMITDAF LKADDYIEIT GAGGKKYRIS TAIDDMEAYT
       430        440        450        460        470        480
KLTDNIFLEI LYSTDPKLKD AREILKQIEY RNLFKYVGET QPTGQIKIKR EDYESLPKEV
       490        500        510        520        530        540
ASAKPKVLLD VKLKAEDFIV DVINMDYGMQ EKNPIDHVSF YCKTAPNRAI RITKNQVSQL
       550        560        570        580        590        600
LPEKFAEQLI RVYCKKVDRK SLYAARQYFV QWCADRNFTK PQDGDVIAPL ITPQKKEWND
       610        620
STSVQNPTRL REASKSRVQL FKDDPM         10         20         30         40         50         60
MQRADSEQPS KRPRCDDSPR TPSNTPSAEA DWSPGLELHP DYKTWGPEQV CSFLRRGGFE
        70         80         90        100        110        120
EPVLLKNIRE NEITGALLPC LDESRFENLG VSSLGERKKL LSYIQRLVQI HVDTMKVIND
       130        140        150        160        170        180
PIHGHIELHP LLVRIIDTPQ FQRLRYIKQL GGGYYVFPGA SHNRFEHSLG VGYLAGCLVH
       190        200        210        220        230        240
ALGEKQPELQ ISERDVLCVQ IAGLCHDLGH GPFSHMFDGR FIPLARPEVK WTHEQGSVMM
       250        260        270        280        290        300
FEHLINSNGI KPVMEQYGLI PEEDICFIKE QIVGPLESPV EDSLWPYKGR PENKSFLYEI
       310        320        330        340        350        360
VSNKRNGIDV DKWDYFARDC HHLGIQNNFD YKRFIKFARV CEVDNELRIC ARDKEVGNLY
       370        380        390        400        410        420
DMFHTRNSLH RRAYQHKVGN IIDTMITDAF LKADDYIEIT GAGGKKYRIS TAIDDMEAYT
       430        440        450        460        470        480
KLTDNIFLEI LYSTDPKLKD AREILKQIEY RNLFKYVGET QPTGQIKIKR EDYESLPKEV
       490        500        510        520        530        540
ASAKPKVLLD VKLKAEDFIV DVINMDYGMQ EKNPIDHVSF YCKTAPNRAI RITKNQVSQL
       550        560        570        580        590        600
LPEKFAEQLI RVYCKKVDRK SLYAARQYFV QWCADRNFTK PQDGDVIAPL ITPQKKEWND
       610        620
STSVQNPTRL REASKSRVQL FKDDPM         10         20         30         40         50         60
MQRADSEQPS KRPRCDDSPR TPSNTPSAEA DWSPGLELHP DYKTWGPEQV CSFLRRGGFE
        70         80         90        100        110        120
EPVLLKNIRE NEITGALLPC LDESRFENLG VSSLGERKKL LSYIQRLVQI HVDTMKVIND
       130        140        150        160        170        180
PIHGHIELHP LLVRIIDTPQ FQRLRYIKQL GGGYYVFPGA SHNRFEHSLG VGYLAGCLVH
       190        200        210        220        230        240
ALGEKQPELQ ISERDVLCVQ IAGLCHDLGH GPFSHMFDGR FIPLARPEVK WTHEQGSVMM
       250        260        270        280        290        300
FEHLINSNGI KPVMEQYGLI PEEDICFIKE QIVGPLESPV EDSLWPYKGR PENKSFLYEI
       310        320        330        340        350        360
VSNKRNGIDV DKWDYFARDC HHLGIQNNFD YKRFIKFARV CEVDNELRIC ARDKEVGNLY
       370        380        390        400        410        420
DMFHTRNSLH RRAYQHKVGN IIDTMITDAF LKADDYIEIT GAGGKKYRIS TAIDDMEAYT
       430        440        450        460        470        480
KLTDNIFLEI LYSTDPKLKD AREILKQIEY RNLFKYVGET QPTGQIKIKR EDYESLPKEV
       490        500        510        520        530        540
ASAKPKVLLD VKLKAEDFIV DVINMDYGMQ EKNPIDHVSF YCKTAPNRAI RITKNQVSQL
       550        560        570        580        590        600
LPEKFAEQLI RVYCKKVDRK SLYAARQYFV QWCADRNFTK PQDGDVIAPL ITPQKKEWND
       610        620
STSVQNPTRL REASKSRVQL FKDDPM

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
Q9Y3Z3-1-Acetylation	MQRADS...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9Y3Z3-1-Acetylation	MQRADS...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt107363
Q9Y3Z3-1-Acetylation	MQRADS...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt107364
Q9Y3Z3-1-Acetylation	MQRADS...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt107365
Q9Y3Z3-1-unknown	MQRADS...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt88870
Q9Y3Z3-1-unknown	MQRADS...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt88871
Q9Y3Z3-1-unknown	MQRADS...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt88872

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...KDDPM	626		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...KDDPM	626		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...KDDPM	626	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...KDDPM	626	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt84489
...KDDPM	626	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt84490
...KDDPM	626	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt84488
...KDDPM	626		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...KDDPM	626		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)