TopFIND 4.0

Q9Y463: Dual specificity tyrosine-phosphorylation-regulated kinase 1B

General Information

Protein names
- Dual specificity tyrosine-phosphorylation-regulated kinase 1B
- 2.7.12.1
- Minibrain-related kinase
- Mirk protein kinase
Gene names DYRK1B
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q9Y463

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MAVPPGHGPF SGFPGPQEHT QVLPDVRLLP RRLPLAFRDA TSAPLRKLSV DLIKTYKHIN 
        70         80         90        100        110        120 
EVYYAKKKRR AQQAPPQDSS NKKEKKVLNH GYDDDNHDYI VRSGERWLER YEIDSLIGKG 
       130        140        150        160        170        180 
SFGQVVKAYD HQTQELVAIK IIKNKKAFLN QAQIELRLLE LMNQHDTEMK YYIVHLKRHF 
       190        200        210        220        230        240 
MFRNHLCLVF ELLSYNLYDL LRNTHFRGVS LNLTRKLAQQ LCTALLFLAT PELSIIHCDL 
       250        260        270        280        290        300 
KPENILLCNP KRSAIKIVDF GSSCQLGQRI YQYIQSRFYR SPEVLLGTPY DLAIDMWSLG 
       310        320        330        340        350        360 
CILVEMHTGE PLFSGSNEVD QMNRIVEVLG IPPAAMLDQA PKARKYFERL PGGGWTLRRT 
       370        380        390        400        410        420 
KELRKDYQGP GTRRLQEVLG VQTGGPGGRR AGEPGHSPAD YLRFQDLVLR MLEYEPAARI 
       430        440        450        460        470        480 
SPLGALQHGF FRRTADEATN TGPAGSSAST SPAPLDTCPS SSTASSISSS GGSSGSSSDN 
       490        500        510        520        530        540 
RTYRYSNRYC GGPGPPITDC EMNSPQVPPS QPLRPWAGGD VPHKTHQAPA SASSLPGTGA 
       550        560        570        580        590        600 
QLPPQPRYLG RPPSPTSPPP PELMDVSLVG GPADCSPPHP APAPQHPAAS ALRTRMTGGR 
       610        620    
PPLPPPDDPA TLGPHLGLRG VPQSTAASS

Isoforms

- Isoform 2 of Dual specificity tyrosine-phosphorylation-regulated kinase 1B - Isoform 3 of Dual specificity tyrosine-phosphorylation-regulated kinase 1B

Sequence View

        10         20         30         40         50         60 
MAVPPGHGPF SGFPGPQEHT QVLPDVRLLP RRLPLAFRDA TSAPLRKLSV DLIKTYKHIN 
        70         80         90        100        110        120 
EVYYAKKKRR AQQAPPQDSS NKKEKKVLNH GYDDDNHDYI VRSGERWLER YEIDSLIGKG 
       130        140        150        160        170        180 
SFGQVVKAYD HQTQELVAIK IIKNKKAFLN QAQIELRLLE LMNQHDTEMK YYIVHLKRHF 
       190        200        210        220        230        240 
MFRNHLCLVF ELLSYNLYDL LRNTHFRGVS LNLTRKLAQQ LCTALLFLAT PELSIIHCDL 
       250        260        270        280        290        300 
KPENILLCNP KRSAIKIVDF GSSCQLGQRI YQYIQSRFYR SPEVLLGTPY DLAIDMWSLG 
       310        320        330        340        350        360 
CILVEMHTGE PLFSGSNEVD QMNRIVEVLG IPPAAMLDQA PKARKYFERL PGGGWTLRRT 
       370        380        390        400        410        420 
KELRKDYQGP GTRRLQEVLG VQTGGPGGRR AGEPGHSPAD YLRFQDLVLR MLEYEPAARI 
       430        440        450        460        470        480 
SPLGALQHGF FRRTADEATN TGPAGSSAST SPAPLDTCPS SSTASSISSS GGSSGSSSDN 
       490        500        510        520        530        540 
RTYRYSNRYC GGPGPPITDC EMNSPQVPPS QPLRPWAGGD VPHKTHQAPA SASSLPGTGA 
       550        560        570        580        590        600 
QLPPQPRYLG RPPSPTSPPP PELMDVSLVG GPADCSPPHP APAPQHPAAS ALRTRMTGGR 
       610        620    
PPLPPPDDPA TLGPHLGLRG VPQSTAASS         10         20         30         40         50         60 
MAVPPGHGPF SGFPGPQEHT QVLPDVRLLP RRLPLAFRDA TSAPLRKLSV DLIKTYKHIN 
        70         80         90        100        110        120 
EVYYAKKKRR AQQAPPQDSS NKKEKKVLNH GYDDDNHDYI VRSGERWLER YEIDSLIGKG 
       130        140        150        160        170        180 
SFGQVVKAYD HQTQELVAIK IIKNKKAFLN QAQIELRLLE LMNQHDTEMK YYIVHLKRHF 
       190        200        210        220        230        240 
MFRNHLCLVF ELLSYNLYDL LRNTHFRGVS LNLTRKLAQQ LCTALLFLAT PELSIIHCDL 
       250        260        270        280        290        300 
KPENILLCNP KRSAIKIVDF GSSCQLGQRI YQYIQSRFYR SPEVLLGTPY DLAIDMWSLG 
       310        320        330        340        350        360 
CILVEMHTGE PLFSGSNEVD QMNRIVEVLG IPPAAMLDQA PKARKYFERL PGGGWTLRRT 
       370        380        390        400        410        420 
KELRKDYQGP GTRRLQEVLG VQTGGPGGRR AGEPGHSPAD YLRFQDLVLR MLEYEPAARI 
       430        440        450        460        470        480 
SPLGALQHGF FRRTADEATN TGPAGSSAST SPAPLDTCPS SSTASSISSS GGSSGSSSDN 
       490        500        510        520        530        540 
RTYRYSNRYC GGPGPPITDC EMNSPQVPPS QPLRPWAGGD VPHKTHQAPA SASSLPGTGA 
       550        560        570        580        590        600 
QLPPQPRYLG RPPSPTSPPP PELMDVSLVG GPADCSPPHP APAPQHPAAS ALRTRMTGGR 
       610        620    
PPLPPPDDPA TLGPHLGLRG VPQSTAASS



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Evidence Codes:


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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q9Y463-1-unknown MAVPPG... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q9Y463-1-unknown MAVPPG... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt73443
    Q9Y463-1-unknown MAVPPG... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt73444

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)