Q9Y4G8: Rap guanine nucleotide exchange factor 2

General Information

Protein names	- Rap guanine nucleotide exchange factor 2 - Cyclic nucleotide ras GEF - CNrasGEF - Neural RAP guanine nucleotide exchange protein - nRap GEP - PDZ domain-containing guanine nucleotide exchange factor 1 - PDZ-GEF1 - RA-GEF-1 - Ras/Rap1-associating GEF-1
Gene names	RAPGEF2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9Y4G8

3 N-termini

8 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MKPLAIPANH GVMGQQEKHS LPADFTKLHL TDSLHPQVTH VSSSHSGCSI TSDSGSSSLS
        70         80         90        100        110        120
DIYQATESEA GDMDLSGLPE TAVDSEDDDD EEDIERASDP LMSRDIVRDC LEKDPIDRTD
       130        140        150        160        170        180
DDIEQLLEFM HQLPAFANMT MSVRRELCAV MVFAVVERAG TIVLNDGEEL DSWSVILNGS
       190        200        210        220        230        240
VEVTYPDGKA EILCMGNSFG VSPTMDKEYM KGVMRTKVDD CQFVCIAQQD YCRILNQVEK
       250        260        270        280        290        300
NMQKVEEEGE IVMVKEHREL DRTGTRKGHI VIKGTSERLT MHLVEEHSVV DPTFIEDFLL
       310        320        330        340        350        360
TYRTFLSSPM EVGKKLLEWF NDPSLRDKVT RVVLLWVNNH FNDFEGDPAM TRFLEEFENN
       370        380        390        400        410        420
LEREKMGGHL RLLNIACAAK AKRRLMTLTK PSREAPLPFI LLGGSEKGFG IFVDSVDSGS
       430        440        450        460        470        480
KATEAGLKRG DQILEVNGQN FENIQLSKAM EILRNNTHLS ITVKTNLFVF KELLTRLSEE
       490        500        510        520        530        540
KRNGAPHLPK IGDIKKASRY SIPDLAVDVE QVIGLEKVNK KSKANTVGGR NKLKKILDKT
       550        560        570        580        590        600
RISILPQKPY NDIGIGQSQD DSIVGLRQTK HIPTALPVSG TLSSSNPDLL QSHHRILDFS
       610        620        630        640        650        660
ATPDLPDQVL RVFKADQQSR YIMISKDTTA KEVVIQAIRE FAVTATPDQY SLCEVSVTPE
       670        680        690        700        710        720
GVIKQRRLPD QLSKLADRIQ LSGRYYLKNN METETLCSDE DAQELLRESQ ISLLQLSTVE
       730        740        750        760        770        780
VATQLSMRNF ELFRNIEPTE YIDDLFKLRS KTSCANLKRF EEVINQETFW VASEILRETN
       790        800        810        820        830        840
QLKRMKIIKH FIKIALHCRE CKNFNSMFAI ISGLNLAPVA RLRTTWEKLP NKYEKLFQDL
       850        860        870        880        890        900
QDLFDPSRNM AKYRNVLNSQ NLQPPIIPLF PVIKKDLTFL HEGNDSKVDG LVNFEKLRMI
       910        920        930        940        950        960
AKEIRHVGRM ASVNMDPALM FRTRKKKWRS LGSLSQGSTN ATVLDVAQTG GHKKRVRRSS
       970        980        990       1000       1010       1020
FLNAKKLYED AQMARKVKQY LSNLELEMDE ESLQTLSLQC EPATNTLPKN PGDKKPVKSE
      1030       1040       1050       1060       1070       1080
TSPVAPRAGS QQKAQSLPQP QQQPPPAHKI NQGLQVPAVS LYPSRKKVPV KDLPPFGINS
      1090       1100       1110       1120       1130       1140
PQALKKILSL SEEGSLERHK KQAEDTISNA SSQLSSPPTS PQSSPRKGYT LAPSGTVDNF
      1150       1160       1170       1180       1190       1200
SDSGHSEISS RSSIVSNSSF DSVPVSLHDE RRQRHSVSIV ETNLGMGRME RRTMIEPDQY
      1210       1220       1230       1240       1250       1260
SLGSYAPMSE GRGLYATATV ISSPSTEELS QDQGDRASLD AADSGRGSWT SCSSGSHDNI
      1270       1280       1290       1300       1310       1320
QTIQHQRSWE TLPFGHTHFD YSGDPAGLWA SSSHMDQIMF SDHSTKYNRQ NQSRESLEQA
      1330       1340       1350       1360       1370       1380
QSRASWASST GYWGEDSEGD TGTIKRRGGK DVSIEAESSS LTSVTTEETK PVPMPAHIAV
      1390       1400       1410       1420       1430       1440
ASSTTKGLIA RKEGRYREPP PTPPGYIGIP ITDFPEGHSH PARKPPDYNV ALQRSRMVAR
      1450       1460       1470       1480       1490
SSDTAGPSSV QQPHGHPTSS RPVNKPQWHK PNESDPRLAP YQSQGFSTEE DEDEQVSAV

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 8 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9Y4G8-1-unknown	MKPLAI...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9Y4G8-73-unknown	MDLSGL...	73	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000421602
Q9Y4G8-600-	SATPDL...	600		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TDDDIE	123	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000422707
...FAVVER	157	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000421740
...ELDSWS	173	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000422361
...TYPDGK	188	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000421602
...DLPPFG	1076	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000422098
...SYAPMS	1208	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000421083
...TKGLIA	1389	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000427334
...QVSAV	1499	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)