Q9Y4K4: Mitogen-activated protein kinase kinase kinase kinase 5

General Information

Protein names	- Mitogen-activated protein kinase kinase kinase kinase 5 - 2.7.11.1 - Kinase homologous to SPS1/STE20 - KHS - MAPK/ERK kinase kinase kinase 5 - MEK kinase kinase 5 - MEKKK 5
Gene names	MAP4K5
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9Y4K4

2 N-termini

4 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MEAPLRPAAD ILRRNPQQDY ELVQRVGSGT YGDVYKARNV HTGELAAVKI IKLEPGDDFS
        70         80         90        100        110        120
LIQQEIFMVK ECKHCNIVAY FGSYLSREKL WICMEYCGGG SLQDIYHVTG PLSELQIAYV
       130        140        150        160        170        180
CRETLQGLAY LHTKGKMHRD IKGANILLTD HGDVKLADFG VAAKITATIA KRKSFIGTPY
       190        200        210        220        230        240
WMAPEVAAVE KNGGYNQLCD IWAVGITAIE LGELQPPMFD LHPMRALFLM SKSNFQPPKL
       250        260        270        280        290        300
KDKTKWSSTF HNFVKIALTK NPKKRPTAER LLTHTFVAQP GLSRALAVEL LDKVNNPDNH
       310        320        330        340        350        360
AHYTEADDDD FEPHAIIRHT IRSTNRNARA ERTASEINFD KLQFEPPLRK ETEARDEMGL
       370        380        390        400        410        420
SSDPNFMLQW NPFVDGANTG KSTSKRAIPP PLPPKPRISS YPEDNFPDEE KASTIKHCPD
       430        440        450        460        470        480
SESRAPQILR RQSSPSCGPV AETSSIGNGD GISKLMSENT EGSAQAPQLP RKKDKRDFPK
       490        500        510        520        530        540
PAINGLPPTP KVLMGACFSK VFDGCPLKIN CATSWIHPDT KDQYIIFGTE DGIYTLNLNE
       550        560        570        580        590        600
LHEATMEQLF PRKCTWLYVI NNTLMSLSVG KTFQLYSHNL IALFEHAKKP GLAAHIQTHR
       610        620        630        640        650        660
FPDRILPRKF ALTTKIPDTK GCHKCCIVRN PYTGHKYLCG ALQSGIVLLQ WYEPMQKFML
       670        680        690        700        710        720
IKHFDFPLPS PLNVFEMLVI PEQEYPMVCV AISKGTESNQ VVQFETINLN SASSWFTEIG
       730        740        750        760        770        780
AGSQQLDSIH VTQLERDTVL VCLDKFVKIV NLQGKLKSSK KLASELSFDF RIESVVCLQD
       790        800        810        820        830        840
SVLAFWKHGM QGKSFKSDEV TQEISDETRV FRLLGSDRVV VLESRPTENP TAHSNLYILA

GHENSY

Isoforms

Sequence View

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(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 4 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9Y4K4-1-unknown	MEAPLR...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9Y4K4-68-unknown	MVKECK...	68		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000452289

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...IKLEPG	55	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000451452
...TKGKMH	137	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000451980
...KRKSFI	175	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000452289
...HENSY	846	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)