Q9Y5X9: Endothelial lipase

General Information

Protein names	- Endothelial lipase - 3.1.1.3 - Endothelial cell-derived lipase - EDL - EL
Gene names	LIPG
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9Y5X9

3 N-termini

2 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSNSVPLLCF WSLCYCFAAG SPVPFGPEGR LEDKLHKPKA TQTEVKPSVR FNLRTSKDPE
        70         80         90        100        110        120
HEGCYLSVGH SQPLEDCSFN MTAKTFFIIH GWTMSGIFEN WLHKLVSALH TREKDANVVV
       130        140        150        160        170        180
VDWLPLAHQL YTDAVNNTRV VGHSIARMLD WLQEKDDFSL GNVHLIGYSL GAHVAGYAGN
       190        200        210        220        230        240
FVKGTVGRIT GLDPAGPMFE GADIHKRLSP DDADFVDVLH TYTRSFGLSI GIQMPVGHID
       250        260        270        280        290        300
IYPNGGDFQP GCGLNDVLGS IAYGTITEVV KCEHERAVHL FVDSLVNQDK PSFAFQCTDS
       310        320        330        340        350        360
NRFKKGICLS CRKNRCNSIG YNAKKMRNKR NSKMYLKTRA GMPFRVYHYQ MKIHVFSYKN
       370        380        390        400        410        420
MGEIEPTFYV TLYGTNADSQ TLPLEIVERI EQNATNTFLV YTEEDLGDLL KIQLTWEGAS
       430        440        450        460        470        480
QSWYNLWKEF RSYLSQPRNP GRELNIRRIR VKSGETQRKL TFCTEDPENT SISPGRELWF
       490        500
RKCRDGWRMK NETSPTVELP

Isoforms

- Isoform 2 of Endothelial lipase

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9Y5X9-1-unknown	MSNSVP...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt79649
Q9Y5X9-21-unknown	SPVPFG...	21	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9Y5X9-21-unknown	SPVPFG...	21	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112597
Q9Y5X9-331-unknown	NSKMYL...	331	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27235
Q9Y5X9-331-unknown	NSKMYL...	331	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9859
Q9Y5X9-331-unknown	NSKMYL...	331	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27087

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...MRNKRN	330	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27235
...MRNKRN	330	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9859
...MRNKRN	330	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27087
...MRNKRN	330	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133945
...TVELP	500	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
PCSK6_HUMAN	330	NKRN.\|.NSKM	inferred from experiment	unknown	MEROPS	Frank S	Gauster M et al.:Endothelial lipase is inactivat... (S08.071)	15722560,
FURIN_HUMAN	330	NKRN.\|.NSKM	inferred from experiment	unknown	MEROPS	Frank S	Gauster M et al.:Endothelial lipase is inactivat... (S08.071)	15722560,
PCSK5_HUMAN	330	NKRN.\|.NSKM	inferred from experiment	unknown	MEROPS	Frank S	Gauster M et al.:Endothelial lipase is inactivat... (S08.071)	15722560,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)