TopFIND 4.0

Q9Y606: tRNA pseudouridine synthase A

General Information

Protein names
- tRNA pseudouridine synthase A
- 5.4.99.12 {ECO:0000305|PubMed:24722331}
- tRNA pseudouridine(38-40) synthase
- tRNA pseudouridylate synthase I
- tRNA-uridine isomerase I
Gene names PUS1
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q9Y606

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MGLQLRALLG AFGRWTLRLG PRPSCSPRMA GNAEPPPAGA ACPQDRRSCS GRAGGDRVWE 
        70         80         90        100        110        120 
DGEHPAKKLK SGGDEERREK PPKRKIVLLM AYSGKGYHGM QRNVGSSQFK TIEDDLVSAL 
       130        140        150        160        170        180 
VRSGCIPENH GEDMRKMSFQ RCARTDKGVS AAGQVVSLKV WLIDDILEKI NSHLPSHIRI 
       190        200        210        220        230        240 
LGLKRVTGGF NSKNRCDART YCYLLPTFAF AHKDRDVQDE TYRLSAETLQ QVNRLLACYK 
       250        260        270        280        290        300 
GTHNFHNFTS QKGPQDPSAC RYILEMYCEE PFVREGLEFA VIRVKGQSFM MHQIRKMVGL 
       310        320        330        340        350        360 
VVAIVKGYAP ESVLERSWGT EKVDVPKAPG LGLVLERVHF EKYNQRFGND GLHEPLDWAQ 
       370        380        390        400        410        420 
EEGKVAAFKE EHIYPTIIGT ERDERSMAQW LSTLPIHNFS ATALTAGGTG AKVPSPLEGS 
   
EGDGDTD

Isoforms

- Isoform 2 of tRNA pseudouridine synthase A, mitochondrial - Isoform 2 of tRNA pseudouridine synthase A

Sequence View

        10         20         30         40         50         60 
MGLQLRALLG AFGRWTLRLG PRPSCSPRMA GNAEPPPAGA ACPQDRRSCS GRAGGDRVWE 
        70         80         90        100        110        120 
DGEHPAKKLK SGGDEERREK PPKRKIVLLM AYSGKGYHGM QRNVGSSQFK TIEDDLVSAL 
       130        140        150        160        170        180 
VRSGCIPENH GEDMRKMSFQ RCARTDKGVS AAGQVVSLKV WLIDDILEKI NSHLPSHIRI 
       190        200        210        220        230        240 
LGLKRVTGGF NSKNRCDART YCYLLPTFAF AHKDRDVQDE TYRLSAETLQ QVNRLLACYK 
       250        260        270        280        290        300 
GTHNFHNFTS QKGPQDPSAC RYILEMYCEE PFVREGLEFA VIRVKGQSFM MHQIRKMVGL 
       310        320        330        340        350        360 
VVAIVKGYAP ESVLERSWGT EKVDVPKAPG LGLVLERVHF EKYNQRFGND GLHEPLDWAQ 
       370        380        390        400        410        420 
EEGKVAAFKE EHIYPTIIGT ERDERSMAQW LSTLPIHNFS ATALTAGGTG AKVPSPLEGS 
   
EGDGDTD         10         20         30         40         50         60 
MGLQLRALLG AFGRWTLRLG PRPSCSPRMA GNAEPPPAGA ACPQDRRSCS GRAGGDRVWE 
        70         80         90        100        110        120 
DGEHPAKKLK SGGDEERREK PPKRKIVLLM AYSGKGYHGM QRNVGSSQFK TIEDDLVSAL 
       130        140        150        160        170        180 
VRSGCIPENH GEDMRKMSFQ RCARTDKGVS AAGQVVSLKV WLIDDILEKI NSHLPSHIRI 
       190        200        210        220        230        240 
LGLKRVTGGF NSKNRCDART YCYLLPTFAF AHKDRDVQDE TYRLSAETLQ QVNRLLACYK 
       250        260        270        280        290        300 
GTHNFHNFTS QKGPQDPSAC RYILEMYCEE PFVREGLEFA VIRVKGQSFM MHQIRKMVGL 
       310        320        330        340        350        360 
VVAIVKGYAP ESVLERSWGT EKVDVPKAPG LGLVLERVHF EKYNQRFGND GLHEPLDWAQ 
       370        380        390        400        410        420 
EEGKVAAFKE EHIYPTIIGT ERDERSMAQW LSTLPIHNFS ATALTAGGTG AKVPSPLEGS 
   
EGDGDTD



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q9Y606-0-unknown DMGLQL... 0 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q9Y606-29-unknown MAGNAE... 29 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt93215

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...DGDTD 427 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...DGDTD 427 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt88833

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)