Q9Y6A2: Cholesterol 24-hydroxylase {ECO:0000305|PubMed:14640697}

General Information

Protein names	- Cholesterol 24-hydroxylase {ECO:0000305\|PubMed:14640697} - CH24H - 1.14.14.25 {ECO:0000269\|PubMed:10377398, ECO:0000269\|PubMed:14640697, ECO:0000269\|PubMed:25017465} - Cholesterol 24-monooxygenase - Cholesterol 24S-hydroxylase {ECO:0000303\|PubMed:10377398} - Cytochrome P450 46A1 {ECO:0000303\|PubMed:14640697}
Gene names	CYP46A1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9Y6A2

4 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Cholesterol 24-hydroxylase - Isoform 3 of Cholesterol 24-hydroxylase

Sequence View

        10         20         30         40         50         60
MSPGLLLLGS AVLLAFGLCC TFVHRARSRY EHIPGPPRPS FLLGHLPCFW KKDEVGGRVL
        70         80         90        100        110        120
QDVFLDWAKK YGPVVRVNVF HKTSVIVTSP ESVKKFLMST KYNKDSKMYR ALQTVFGERL
       130        140        150        160        170        180
FGQGLVSECN YERWHKQRRV IDLAFSRSSL VSLMETFNEK AEQLVEILEA KADGQTPVSM
       190        200        210        220        230        240
QDMLTYTAMD ILAKAAFGME TSMLLGAQKP LSQAVKLMLE GITASRNTLA KFLPGKRKQL
       250        260        270        280        290        300
REVRESIRFL RQVGRDWVQR RREALKRGEE VPADILTQIL KAEEGAQDDE GLLDNFVTFF
       310        320        330        340        350        360
IAGHETSANH LAFTVMELSR QPEIVARLQA EVDEVIGSKR YLDFEDLGRL QYLSQVLKES
       370        380        390        400        410        420
LRLYPPAWGT FRLLEEETLI DGVRVPGNTP LLFSTYVMGR MDTYFEDPLT FNPDRFGPGA
       430        440        450        460        470        480
PKPRFTYFPF SLGHRSCIGQ QFAQMEVKVV MAKLLQRLEF RLVPGQRFGL QEQATLKPLD
       490        500
PVLCTLRPRG WQPAPPPPPC         10         20         30         40         50         60
MSPGLLLLGS AVLLAFGLCC TFVHRARSRY EHIPGPPRPS FLLGHLPCFW KKDEVGGRVL
        70         80         90        100        110        120
QDVFLDWAKK YGPVVRVNVF HKTSVIVTSP ESVKKFLMST KYNKDSKMYR ALQTVFGERL
       130        140        150        160        170        180
FGQGLVSECN YERWHKQRRV IDLAFSRSSL VSLMETFNEK AEQLVEILEA KADGQTPVSM
       190        200        210        220        230        240
QDMLTYTAMD ILAKAAFGME TSMLLGAQKP LSQAVKLMLE GITASRNTLA KFLPGKRKQL
       250        260        270        280        290        300
REVRESIRFL RQVGRDWVQR RREALKRGEE VPADILTQIL KAEEGAQDDE GLLDNFVTFF
       310        320        330        340        350        360
IAGHETSANH LAFTVMELSR QPEIVARLQA EVDEVIGSKR YLDFEDLGRL QYLSQVLKES
       370        380        390        400        410        420
LRLYPPAWGT FRLLEEETLI DGVRVPGNTP LLFSTYVMGR MDTYFEDPLT FNPDRFGPGA
       430        440        450        460        470        480
PKPRFTYFPF SLGHRSCIGQ QFAQMEVKVV MAKLLQRLEF RLVPGQRFGL QEQATLKPLD
       490        500
PVLCTLRPRG WQPAPPPPPC

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9Y6A2-1-unknown	MSPGLL...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9Y6A2-98-unknown	MSTKYN...	98	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt71527
Q9Y6A2-98-unknown	MSTKYN...	98	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000405779
Q9Y6A2-154-unknown	METFNE...	154	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt71528
Q9Y6A2-154-unknown	METFNE...	154	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000450553
Q9Y6A2-154-unknown	METFNE...	154	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt101786
Q9Y6A2-248-unknown	RFLRQV...	248	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000451602
Q9Y6A2-248-unknown	RFLRQV...	248	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt129092
Q9Y6A2-248-unknown	RFLRQV...	248	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt129091

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PPPPC	500	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PPPPC	500	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt67146
...PPPPC	500	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt67145

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)