TopFIND 4.0

Q9Y6F1: Protein mono-ADP-ribosyltransferase PARP3 {ECO:0000305}

General Information

Protein names
- Protein mono-ADP-ribosyltransferase PARP3 {ECO:0000305}
- 2.4.2.- {ECO:0000269|PubMed:16924674, ECO:0000269|PubMed:25043379}
- ADP-ribosyltransferase diphtheria toxin-like 3 {ECO:0000303|PubMed:20106667}
- ARTD3 {ECO:0000303|PubMed:20106667}
- DNA ADP-ribosyltransferase PARP3 {ECO:0000305}
- 2.4.2.- {ECO:0000269|PubMed:29361132}
- IRT1
- NAD(+) ADP-ribosyltransferase 3 {ECO:0000303|PubMed:20106667}
- ADPRT-3 {ECO:0000303|PubMed:20106667}
- Poly ADP-ribose] polymerase 3 {ECO:0000303|PubMed:12640039, ECO:0000303|PubMed:20106667}
- PARP-3 {ECO:0000303|PubMed:12640039}
- hPARP-3 {ECO:0000303|PubMed:12640039}
- PolyADP-ribose] synthase 3 {ECO:0000303|PubMed:20106667}
- pADPRT-3 {ECO:0000303|PubMed:20106667}
Gene names PARP3
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q9Y6F1

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MAPKPKPWVQ TEGPEKKKGR QAGREEDPFR STAEALKAIP AEKRIIRVDP TCPLSSNPGT 
        70         80         90        100        110        120 
QVYEDYNCTL NQTNIENNNN KFYIIQLLQD SNRFFTCWNR WGRVGEVGQS KINHFTRLED 
       130        140        150        160        170        180 
AKKDFEKKFR EKTKNNWAER DHFVSHPGKY TLIEVQAEDE AQEAVVKVDR GPVRTVTKRV 
       190        200        210        220        230        240 
QPCSLDPATQ KLITNIFSKE MFKNTMALMD LDVKKMPLGK LSKQQIARGF EALEALEEAL 
       250        260        270        280        290        300 
KGPTDGGQSL EELSSHFYTV IPHNFGHSQP PPINSPELLQ AKKDMLLVLA DIELAQALQA 
       310        320        330        340        350        360 
VSEQEKTVEE VPHPLDRDYQ LLKCQLQLLD SGAPEYKVIQ TYLEQTGSNH RCPTLQHIWK 
       370        380        390        400        410        420 
VNQEGEEDRF QAHSKLGNRK LLWHGTNMAV VAAILTSGLR IMPHSGGRVG KGIYFASENS 
       430        440        450        460        470        480 
KSAGYVIGMK CGAHHVGYMF LGEVALGREH HINTDNPSLK SPPPGFDSVI ARGHTEPDPT 
       490        500        510        520        530    
QDTELELDGQ QVVVPQGQPV PCPEFSSSTF SQSEYLIYQE SQCRLRYLLE VHL

Isoforms

- Isoform 2 of Poly [ADP-ribose] polymerase 3 - Isoform 2 of Protein mono-ADP-ribosyltransferase PARP3

Sequence View

        10         20         30         40         50         60 
MAPKPKPWVQ TEGPEKKKGR QAGREEDPFR STAEALKAIP AEKRIIRVDP TCPLSSNPGT 
        70         80         90        100        110        120 
QVYEDYNCTL NQTNIENNNN KFYIIQLLQD SNRFFTCWNR WGRVGEVGQS KINHFTRLED 
       130        140        150        160        170        180 
AKKDFEKKFR EKTKNNWAER DHFVSHPGKY TLIEVQAEDE AQEAVVKVDR GPVRTVTKRV 
       190        200        210        220        230        240 
QPCSLDPATQ KLITNIFSKE MFKNTMALMD LDVKKMPLGK LSKQQIARGF EALEALEEAL 
       250        260        270        280        290        300 
KGPTDGGQSL EELSSHFYTV IPHNFGHSQP PPINSPELLQ AKKDMLLVLA DIELAQALQA 
       310        320        330        340        350        360 
VSEQEKTVEE VPHPLDRDYQ LLKCQLQLLD SGAPEYKVIQ TYLEQTGSNH RCPTLQHIWK 
       370        380        390        400        410        420 
VNQEGEEDRF QAHSKLGNRK LLWHGTNMAV VAAILTSGLR IMPHSGGRVG KGIYFASENS 
       430        440        450        460        470        480 
KSAGYVIGMK CGAHHVGYMF LGEVALGREH HINTDNPSLK SPPPGFDSVI ARGHTEPDPT 
       490        500        510        520        530    
QDTELELDGQ QVVVPQGQPV PCPEFSSSTF SQSEYLIYQE SQCRLRYLLE VHL         10         20         30         40         50         60 
MAPKPKPWVQ TEGPEKKKGR QAGREEDPFR STAEALKAIP AEKRIIRVDP TCPLSSNPGT 
        70         80         90        100        110        120 
QVYEDYNCTL NQTNIENNNN KFYIIQLLQD SNRFFTCWNR WGRVGEVGQS KINHFTRLED 
       130        140        150        160        170        180 
AKKDFEKKFR EKTKNNWAER DHFVSHPGKY TLIEVQAEDE AQEAVVKVDR GPVRTVTKRV 
       190        200        210        220        230        240 
QPCSLDPATQ KLITNIFSKE MFKNTMALMD LDVKKMPLGK LSKQQIARGF EALEALEEAL 
       250        260        270        280        290        300 
KGPTDGGQSL EELSSHFYTV IPHNFGHSQP PPINSPELLQ AKKDMLLVLA DIELAQALQA 
       310        320        330        340        350        360 
VSEQEKTVEE VPHPLDRDYQ LLKCQLQLLD SGAPEYKVIQ TYLEQTGSNH RCPTLQHIWK 
       370        380        390        400        410        420 
VNQEGEEDRF QAHSKLGNRK LLWHGTNMAV VAAILTSGLR IMPHSGGRVG KGIYFASENS 
       430        440        450        460        470        480 
KSAGYVIGMK CGAHHVGYMF LGEVALGREH HINTDNPSLK SPPPGFDSVI ARGHTEPDPT 
       490        500        510        520        530    
QDTELELDGQ QVVVPQGQPV PCPEFSSSTF SQSEYLIYQE SQCRLRYLLE VHL



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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q9Y6F1-1-unknown MAPKPK... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q9Y6F1-1-unknown MAPKPK... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt102935

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...LEVHL 533 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...LEVHL 533 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt79943

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)